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Bibliographic Details
Main Author:	Doralinda Asunción de Guzmán
Format:	Artículo científico
Language:	es
Published:	Instituto Nacional de Salud Pública 2007
Subjects:	Salud lisina micotoxina mutagénico aducto AFB1 mutación p53
Online Access:	https://www.redalyc.org/articulo.oa?id=10649308
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La exposición a la aflatoxina B1 en animales de laboratorio y su significado en la salud pública Doralinda Asunción de Guzmán Salud lisina micotoxina mutagénico aducto AFB1 mutación p53 En México se ha detectado la presencia AFB1 en humanos:como mutación en el gene p53 en hepatocarcinomas depacientes de Monterrey, Nuevo León, México, en 1996 ycomo aducto AFB1-lisina en suero de pacientes del InstitutoMexicano del Seguro Social de Matamoros, Tamaulipas, México,en 2003. La aflatoxina B1 ha sido clasificada por la AgenciaInternacional para Investigación en Cáncer como un agentecarcinogénico para humanos. Este compuesto es un contaminantenatural encontrado en alimentos y es sintetizado porAspergillus flavus y/o A. parasiticus cuando estos hongos crecenen diversos productos alimenticios. Considerando el riesgoque este compuesto representa para los seres humanos, enel presente artículo se revisa y analiza, a nivel molecular, sucapacidad carcinogénica, mutagénica y tóxica y se ilustra surelación causal con hepatocarcinomas en humanos. Se destacaque la capacidad carcinogénica y mutagénica están determinadaspor la AFB1-formamidopirimidina, la cual causa erroresen las transcripciones del ADN. Los resultados ilustran quela población mexicana está consumiendo alimentos con bajasconcentraciones de AFB1. La toxicidad es consecuencia de laacción carcinogénica en el hígado. 2007 artículo científico 0036-3634 https://www.redalyc.org/articulo.oa?id=10649308 es http://www.redalyc.org/revista.oa?id=106 Salud Pública de México application/pdf Instituto Nacional de Salud Pública Salud Pública de México (México) Num.3 Vol.49

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// Anecdotal testing Today and Yesterday seems to indicate destroy() // is called by the garbage collector and everything is good. // Something to keep in mind though. return 0; } /** * Write function that is called when session data is to be saved. * * @param string $sessId The current session ID * @param string $data The session data to write * * @return bool */ public function write($sessId, $data): bool { if ($this->writesDisabled) { return true; } return $this->saveSession($sessId, $data); } /** * A function that is called internally when session data is to be saved. * * @param string $sessId The current session ID * @param string $data The session data to write * * @return bool */ abstract protected function saveSession($sessId, $data): bool; }

* * @return void */ public function writeClose() { // The assumption is that we're using PHP's ext/session. // session_write_close() will actually overwrite $_SESSION with an // empty array on completion -- which leads to a mismatch between what // is in the storage object and $_SESSION. To get around this, we // temporarily reset $_SESSION to an array, and then re-link it to // the storage object. // // Additionally, while you _can_ write to $_SESSION following a // session_write_close() operation, no changes made to it will be // flushed to the session handler. As such, we now mark the storage // object isImmutable. $storage = $this->getStorage(); if (! $storage->isImmutable()) { $_SESSION = $storage->toArray(true); session_write_close(); $storage->fromArray($_SESSION); $storage->markImmutable(); } } /** * Attempt to set the session name * * If the session has already been started, or if the name provided fails * validation, an exception will be raised. * * @param string $name * @return SessionManager * @throws Exception\InvalidArgumentException */ public function setName($name) { if ($this->sessionExists()) { throw new Exception\InvalidArgumentException( 'Cannot set session name after a session has already started'

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