CYP1A1, CYP1B1, GSTM1 and GSTT1 genetic variants and breast cancer risk in Mexican women
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Instituto Nacional de Salud Pública
2017
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| author | Angélica García-Martínez |
| author_facet | Angélica García-Martínez |
| contents | CYP1A1, CYP1B1, GSTM1 and GSTT1 genetic variants and breast cancer risk in Mexican women Angélica García-Martínez Brenda Gamboa-Loira M Elizabeth Tejero Adolfo Sierra-Santoyo Mariano E Cebrián Lizbeth López-Carrillo Salud case Mexico control studies Breast neoplasms genetic susceptibility Objective. To evaluate if variants in the genes CYP1A1 (T3801C and A4889G), CYP1B1 (G119T), GSTM1 (indel) and GSTT1 (indel) are associated with breast cancer (BC) among Mexican women. Materials and methods. 952 incident cases with histologically confirmed BC were matched by age (± 5 years) and zone of residence with 998 healthy population controls. Genetic variants in genes CYP1A1 , CYP1B1, GSTM1 and GSTT1 were genotyped by allelic discrimination and multiplex PCR. In a subsample of women, 105 markers for ancestry were determined. Results. An increased BC risk, independent of other BC risk factors, was observed among carriers of CYP1B1 G119T genotype (T/T vs . G/G: OR=1.9; 95%CI 1.4-2.5). Conclusion. Our results support the ex- istence of genetic susceptibility for BC conferred by CYP1B1 G119T variant among Mexican women. 2017 artículo científico 0036-3634 https://www.redalyc.org/articulo.oa?id=10653301017 en http://www.redalyc.org/revista.oa?id=106 Salud Pública de México application/pdf Instituto Nacional de Salud Pública Salud Pública de México (México) Num.5 Vol.59 |
| format | Artículo científico |
| id | redalyc_10653301017 |
| institution | Redalyc |
| language | en |
| publishDate | 2017 |
| publisher | Instituto Nacional de Salud Pública |
| spellingShingle | CYP1A1, CYP1B1, GSTM1 and GSTT1 genetic variants and breast cancer risk in Mexican women Angélica García-Martínez Salud case Mexico control studies Breast neoplasms genetic susceptibility CYP1A1, CYP1B1, GSTM1 and GSTT1 genetic variants and breast cancer risk in Mexican women Angélica García-Martínez Brenda Gamboa-Loira M Elizabeth Tejero Adolfo Sierra-Santoyo Mariano E Cebrián Lizbeth López-Carrillo Salud case Mexico control studies Breast neoplasms genetic susceptibility Objective. To evaluate if variants in the genes CYP1A1 (T3801C and A4889G), CYP1B1 (G119T), GSTM1 (indel) and GSTT1 (indel) are associated with breast cancer (BC) among Mexican women. Materials and methods. 952 incident cases with histologically confirmed BC were matched by age (± 5 years) and zone of residence with 998 healthy population controls. Genetic variants in genes CYP1A1 , CYP1B1, GSTM1 and GSTT1 were genotyped by allelic discrimination and multiplex PCR. In a subsample of women, 105 markers for ancestry were determined. Results. An increased BC risk, independent of other BC risk factors, was observed among carriers of CYP1B1 G119T genotype (T/T vs . G/G: OR=1.9; 95%CI 1.4-2.5). Conclusion. Our results support the ex- istence of genetic susceptibility for BC conferred by CYP1B1 G119T variant among Mexican women. 2017 artículo científico 0036-3634 https://www.redalyc.org/articulo.oa?id=10653301017 en http://www.redalyc.org/revista.oa?id=106 Salud Pública de México application/pdf Instituto Nacional de Salud Pública Salud Pública de México (México) Num.5 Vol.59 |
| title | CYP1A1, CYP1B1, GSTM1 and GSTT1 genetic variants and breast cancer risk in Mexican women |
| topic | Salud case Mexico control studies Breast neoplasms genetic susceptibility |
| url | https://www.redalyc.org/articulo.oa?id=10653301017 |