High relative abundance of firmicutes and increased TNF-α levels correlate with obesity in children
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| Format: | Artículo científico |
| Language: | en |
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Instituto Nacional de Salud Pública
2018
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| _version_ | 1876452937111175168 |
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| author | Yaneth C Orbe-Orihuela |
| author_facet | Yaneth C Orbe-Orihuela |
| contents | High relative abundance of firmicutes and increased TNF-α levels correlate with obesity in children Yaneth C Orbe-Orihuela Alfredo Lagunas-Martínez Margarita Bahena-Román Vicente Madrid-Marina Kirvis Torres-Poveda Eugenia Flores-Alfaro Araceli Méndez-Padrón Cinthya E Díaz-Benítez Oscar Peralta-Zaragoza Diana Antúnez-Ortiz Miguel Cruz Ana I Burguete-García Salud TNF child obesity Microbiota Objective. To investigate the correlation among pro- or anti-inflammatory cytokines and the two main gut microbiota phyla in obese children. Materials and methods. Anthro - pometric data were obtained from 890 children under 14 years old to determine the degree of obesity. Serum cytokine concentration was measured by ELISA. Relative abundance of gut microbiota in feces was evaluated by quantitative Real-Time PCR assays. Results. Anthropometric and bio - chemical parameters were statistically higher in overweight /obese children than in lean ones. Increased TNF- α levels were found in obese children that also have a high relative abundance of Firmicutes. Conclusions. Obese children have a high relative abundance of Firmicutes that correlates with increased levels of TNF- α . This is the first study that shows a relation between Firmicute abundance and TNF- α serum concentration in obese children. 2018 artículo científico 0036-3634 https://www.redalyc.org/articulo.oa?id=10653403003 en http://www.redalyc.org/revista.oa?id=106 Salud Pública de México application/pdf Instituto Nacional de Salud Pública Salud Pública de México (México) Vol.60 |
| format | Artículo científico |
| id | redalyc_10653403003 |
| institution | Redalyc |
| language | en |
| publishDate | 2018 |
| publisher | Instituto Nacional de Salud Pública |
| spellingShingle | High relative abundance of firmicutes and increased TNF-α levels correlate with obesity in children Yaneth C Orbe-Orihuela Salud TNF child obesity Microbiota High relative abundance of firmicutes and increased TNF-α levels correlate with obesity in children Yaneth C Orbe-Orihuela Alfredo Lagunas-Martínez Margarita Bahena-Román Vicente Madrid-Marina Kirvis Torres-Poveda Eugenia Flores-Alfaro Araceli Méndez-Padrón Cinthya E Díaz-Benítez Oscar Peralta-Zaragoza Diana Antúnez-Ortiz Miguel Cruz Ana I Burguete-García Salud TNF child obesity Microbiota Objective. To investigate the correlation among pro- or anti-inflammatory cytokines and the two main gut microbiota phyla in obese children. Materials and methods. Anthro - pometric data were obtained from 890 children under 14 years old to determine the degree of obesity. Serum cytokine concentration was measured by ELISA. Relative abundance of gut microbiota in feces was evaluated by quantitative Real-Time PCR assays. Results. Anthropometric and bio - chemical parameters were statistically higher in overweight /obese children than in lean ones. Increased TNF- α levels were found in obese children that also have a high relative abundance of Firmicutes. Conclusions. Obese children have a high relative abundance of Firmicutes that correlates with increased levels of TNF- α . This is the first study that shows a relation between Firmicute abundance and TNF- α serum concentration in obese children. 2018 artículo científico 0036-3634 https://www.redalyc.org/articulo.oa?id=10653403003 en http://www.redalyc.org/revista.oa?id=106 Salud Pública de México application/pdf Instituto Nacional de Salud Pública Salud Pública de México (México) Vol.60 |
| title | High relative abundance of firmicutes and increased TNF-α levels correlate with obesity in children |
| topic | Salud TNF child obesity Microbiota |
| url | https://www.redalyc.org/articulo.oa?id=10653403003 |