Genetic differences between mestizo populations of Bolivia and Peru
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| Format: | Artículo científico |
| Langue: | en |
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Instituto Francés de Estudios Andinos
2003
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| _version_ | 1876449454276476928 |
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| author | Jorge Cervantes |
| author_facet | Jorge Cervantes |
| contents | Genetic differences between mestizo populations of Bolivia and Peru Jorge Cervantes Multidisciplinarias (Ciencias Sociales) HLA DNA allele Mestizo Data on the genetic background of Peruvian and Bolivian populations is still scarce.Studies have shown that mestizos (i.e. mixed, but of predominantly Native American ancestry)present several HLA alleles originally described in genetically isolated Amerindian tribes, andthat Peruvian and Bolivian mestizos are closely genetically related.Using Reverse Line Blot Assay, HLA typing for Class I (HLA-A, HLA-B, and HLA-Cw)as well as for Class II (HLA-DRB1 and HLA-DQB1) alleles was performed in 57 Bolivianmestizos. Subjects came mainly from La Paz (the main city in the Bolivian Andes) and three otherimportant cities located in the Bolivian Central Valley (Sucre, Tarija and Tupiza).Comparison of the allele frequencies of Bolivian mestizos with available data from theliterature from Peruvian mestizos, revealed that Class I HLA-Cw*01, and B*40 alleles werehigher in the Peruvian mestizo group (Chi-sq = 4,87 p<0,05; and chi-sq = 7,56 p<0,01 respectively).Regarding Class II alleles, HLA-DRB1*1101 and DRB1*1302 alleles were higher in Peruvianmestizos (Chi-sq = 5,12 p<.05; chi-sq = 3,8 p = 0.05 respectively), while HLA-DQB1*0402 wassignificantly higher in Bolivian mestizos (Chi-sq = 47,2 p<.0001).Differences in allele frequencies, and the absence or presence of certain alleles in eithergroup could be due to a higher grade of admixture with Andean ethnic groups in the mestizos fromBolivia and/or less rural traits and more white (Caucasian) admixture in the Peruvian mestizosreported in the literature.These findings may have an impact regarding efficacies of modern forms of immunization(DNA vaccines) in Andean population, as well as in the identification of groups at risk for certainmedical conditions. 2003 artículo científico 0303-7495 https://www.redalyc.org/articulo.oa?id=12632109 en http://www.redalyc.org/revista.oa?id=126 Bulletin de l'Institut français d'études andines application/pdf Instituto Francés de Estudios Andinos Bulletin de l'Institut français d'études andines (Perú) Num.1 Vol.32 |
| format | Artículo científico |
| id | redalyc_12632109 |
| institution | Redalyc |
| language | en |
| publishDate | 2003 |
| publisher | Instituto Francés de Estudios Andinos |
| spellingShingle | Genetic differences between mestizo populations of Bolivia and Peru Jorge Cervantes Multidisciplinarias (Ciencias Sociales) HLA DNA allele Mestizo Genetic differences between mestizo populations of Bolivia and Peru Jorge Cervantes Multidisciplinarias (Ciencias Sociales) HLA DNA allele Mestizo Data on the genetic background of Peruvian and Bolivian populations is still scarce.Studies have shown that mestizos (i.e. mixed, but of predominantly Native American ancestry)present several HLA alleles originally described in genetically isolated Amerindian tribes, andthat Peruvian and Bolivian mestizos are closely genetically related.Using Reverse Line Blot Assay, HLA typing for Class I (HLA-A, HLA-B, and HLA-Cw)as well as for Class II (HLA-DRB1 and HLA-DQB1) alleles was performed in 57 Bolivianmestizos. Subjects came mainly from La Paz (the main city in the Bolivian Andes) and three otherimportant cities located in the Bolivian Central Valley (Sucre, Tarija and Tupiza).Comparison of the allele frequencies of Bolivian mestizos with available data from theliterature from Peruvian mestizos, revealed that Class I HLA-Cw*01, and B*40 alleles werehigher in the Peruvian mestizo group (Chi-sq = 4,87 p<0,05; and chi-sq = 7,56 p<0,01 respectively).Regarding Class II alleles, HLA-DRB1*1101 and DRB1*1302 alleles were higher in Peruvianmestizos (Chi-sq = 5,12 p<.05; chi-sq = 3,8 p = 0.05 respectively), while HLA-DQB1*0402 wassignificantly higher in Bolivian mestizos (Chi-sq = 47,2 p<.0001).Differences in allele frequencies, and the absence or presence of certain alleles in eithergroup could be due to a higher grade of admixture with Andean ethnic groups in the mestizos fromBolivia and/or less rural traits and more white (Caucasian) admixture in the Peruvian mestizosreported in the literature.These findings may have an impact regarding efficacies of modern forms of immunization(DNA vaccines) in Andean population, as well as in the identification of groups at risk for certainmedical conditions. 2003 artículo científico 0303-7495 https://www.redalyc.org/articulo.oa?id=12632109 en http://www.redalyc.org/revista.oa?id=126 Bulletin de l'Institut français d'études andines application/pdf Instituto Francés de Estudios Andinos Bulletin de l'Institut français d'études andines (Perú) Num.1 Vol.32 |
| title | Genetic differences between mestizo populations of Bolivia and Peru |
| topic | Multidisciplinarias (Ciencias Sociales) HLA DNA allele Mestizo |
| url | https://www.redalyc.org/articulo.oa?id=12632109 |