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1. Verfasser:	ZAMIRA HELENA HERNÁNDEZ NAZARÁ
Format:	Artículo científico
Sprache:	es
Veröffentlicht:	Universidad de Guadalajara 2005
Schlagworte:	Salud B1 TGF TNF ALPHA EBP B
Online-Zugang:	https://www.redalyc.org/articulo.oa?id=14220648008
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Mecanismos moleculares de la regulación transcripcional de colágena a1(I) por las células estelares hepáticas ZAMIRA HELENA HERNÁNDEZ NAZARÁ ERIKA MARTÍNEZ LÓPEZ JOSÉ ALFREDO DOMÍNGUEZ ROSALES Salud B1 TGF TNF ALPHA EBP B Las celulas estelares hepaticas (CEH), se localizan en el interior del espacio de Disse del sinusoide hepatico. En estado de reposo, producen las proteinas de tejido conectivo que forman el estroma hepatico y es el principal deposito de vitamina A. Sin embargo, ante un estimulo nocivo, sufre un proceso de cambio fenotipico conocido como activacion. Las celulas activadas se caracterizan por el incremento de la expresion de la colagena tipo I, lo que en estado cronico lleva a la fibrosis o cirrosis del higado. Actualmente, se sabe que la activacion de estas celulas depende de un grupo de citocinas (PDGF-BB, TGF-B1,TNF-a) producidas por las celulas de kuppfer o incluso por las mismas CEH, que a su vez, activan a un grupo de factores transcripcionales que se unen al promotor de las colagenas alfa 1(I) y 2(I) y regulan la expresion del gen. 2005 artículo científico 1405-7980 https://www.redalyc.org/articulo.oa?id=14220648008 es http://www.redalyc.org/revista.oa?id=142 Investigación en Salud application/pdf Universidad de Guadalajara Investigación en Salud (México) Num.1 Vol.VII

if (filemtime($filename) + $maxlifetime < time()) { unlink($filename); $count++; } } return $count; } /** * A function that is called internally when session data is to be saved. * * @param string $sessId The current session ID * @param string $data The session data to write * * @return bool */ protected function saveSession($sessId, $data): bool { $sessFile = $this->path . '/sess_' . $sessId; if ($handle = fopen($sessFile, 'w')) { $return = false; // Lock the file for exclusive access to avoid issues with multiple // processes writing session simultaneously: if (flock($handle, LOCK_EX)) { $return = fwrite($handle, $data); // Make sure that there's no trailing data by truncating the file to // the correct length: ftruncate($handle, strlen($data)); fflush($handle); flock($handle, LOCK_UN); } fclose($handle); if ($return !== false) { return true; } } // If we got this far, something went wrong with the file output... // It is tempting to throw an exception here, but this code is called // outside of the context of exception handling, so all we can do is // echo a message.

// Anecdotal testing Today and Yesterday seems to indicate destroy() // is called by the garbage collector and everything is good. // Something to keep in mind though. return 0; } /** * Write function that is called when session data is to be saved. * * @param string $sessId The current session ID * @param string $data The session data to write * * @return bool */ public function write($sessId, $data): bool { if ($this->writesDisabled) { return true; } return $this->saveSession($sessId, $data); } /** * A function that is called internally when session data is to be saved. * * @param string $sessId The current session ID * @param string $data The session data to write * * @return bool */ abstract protected function saveSession($sessId, $data): bool; }

* * @return void */ public function writeClose() { // The assumption is that we're using PHP's ext/session. // session_write_close() will actually overwrite $_SESSION with an // empty array on completion -- which leads to a mismatch between what // is in the storage object and $_SESSION. To get around this, we // temporarily reset $_SESSION to an array, and then re-link it to // the storage object. // // Additionally, while you _can_ write to $_SESSION following a // session_write_close() operation, no changes made to it will be // flushed to the session handler. As such, we now mark the storage // object isImmutable. $storage = $this->getStorage(); if (! $storage->isImmutable()) { $_SESSION = $storage->toArray(true); session_write_close(); $storage->fromArray($_SESSION); $storage->markImmutable(); } } /** * Attempt to set the session name * * If the session has already been started, or if the name provided fails * validation, an exception will be raised. * * @param string $name * @return SessionManager * @throws Exception\InvalidArgumentException */ public function setName($name) { if ($this->sessionExists()) { throw new Exception\InvalidArgumentException( 'Cannot set session name after a session has already started'

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