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| Format: | Artículo científico |
| Sprache: | en |
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Universidad Pontificia Bolivariana
2022
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| Online-Zugang: | https://www.redalyc.org/articulo.oa?id=159072226006 https://www.redalyc.org/journal/1590/159072226006/ https://www.redalyc.org/journal/1590/159072226006/html/ https://www.redalyc.org/journal/1590/159072226006/159072226006.epub https://www.redalyc.org/journal/1590/159072226006/movil https://doi.org/10.18566/medupb.v41n2.a06 |
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Inhaltsangabe:
- Etiopathogenesis of drug dependence: an explanatory synthesis from an epigenetic perspective Carlos Arturo Cassiani-Miranda Alexander Blanco-Palomino Yinneth Andrea Arismendy-López Natalia Marcela Socarrás-De la hoz Medicina genes Etiology substance environment epigenomics The use of substances with addictive potential is a relevant health problem. Scientific evidence suggests that the underlying mechanisms that regulate behavioral processes in addictions involve a complex interplay between genetic and environmental factors. Therefore, this narrative review aims to provide a framework to synthesize the evidence on gene-environment-agent interactions from the perspective of the natural history of the disease and the stages of the addictive process for alcohol, nicotine, cannabis, psychostimulants, and opioids. In this review, we conducted an exhaustive literature search without time limits in PubMed, Ebsco, Lilacs, and SciELO, reviewing the title and abstract we selected original articles in humans or animals that addressed the etiology of addictions according to the methodological approach of gene-environment (G-E) interaction, including articles in Spanish, English, and Portuguese. Genetic studies have revealed the critical role of epigenetic modifiers (histone acetylation) in maintaining brain homeostasis in pathological conditions and focusing on G-E interactions will also allow characterizing subgroups (based on environmental factors) at high risk for addictive behaviors that can be targeted for specific interventions, Thus, treatment strategies should encompass a combination of psychosocial interventions with gene therapy involving pharmacological manipulations of histones that may contribute to design better therapies and perhaps lead to more successful management of drug dependencies. 2022 artículo científico 0120-4874 https://www.redalyc.org/articulo.oa?id=159072226006 https://www.redalyc.org/journal/1590/159072226006/ https://www.redalyc.org/journal/1590/159072226006/html/ https://www.redalyc.org/journal/1590/159072226006/159072226006.epub https://www.redalyc.org/journal/1590/159072226006/movil https://doi.org/10.18566/medupb.v41n2.a06 en http://www.redalyc.org/revista.oa?id=1590 Medicina U.P.B. application/pdf Universidad Pontificia Bolivariana Medicina U.P.B. (Colombia) Num.2 Vol.41