Involvement of central airways in vibroacoustic disease patients
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| Natura: | Artículo científico |
| Lingua: | en |
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Sociedade Portuguesa de Pneumologia
2006
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| _version_ | 1876435098887258112 |
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| author | José Reis Ferreira |
| author_facet | José Reis Ferreira |
| contents | Involvement of central airways in vibroacoustic disease patients José Reis Ferreira Miguel B Monteiro Fernanda Tavares Isabel Serrano Emanuel Monteiro Carla P Mendes Mariana Alves-Pereira Nuno A A Castelo Branco Medicina auto mecano displasia apoptosis transduction Introduction. Vibroacoustic disease (VAD) is the whole-body pathology caused by excessive exposure to LFN. For the past 25 years, it has been know that low frequency noise (LFN, <500 Hz, including infrasound) targets the respiratory system. In LFN-exposed rodents, the morphological changes of respiratory tract tissue partially explained some respiratory symptoms reported by VAD patients. However, many questions remain unanswered. Recently, some volunteer VAD patients underwent bronchoscopy in order to ascertain possible damage that could be associated with their respiratory complaints. Methods. Fourteen fully-informed and volunteer VAD patients were submitted to bronchoscopy, and biopsies were removed for analysis. Results. All patients exhibited small submucosal vascular-like lesions near the spurs, consisting of increased collagen and elastin fibres. Histology disclosed cilliary abnormalities, basal membrane hyperplasia, and thickening of vessel walls. In five patients, collagen bundles appeared degenerative and disrupted. No inflammatory process was ever identified, and no differences were seen between smokers and non-smokers. Discussion. Data is in accordance with what was observed in LFN-exposed animal models and also in 8 VAD patients who developed lung tumours. Collagen disruption and degeneration was also observed in electron microscopy images of the respiratory tract of LFN-exposed rodents. Thickened blood and lymphatic vessel walls have been consistently seen in images of VAD patients and of LFN-exposed rodents. During bronchoscopy performed by other reasons, this sort of structural aspects is not frequently seen. Taken together, it is strongly suggested that these findings could be VAD-specific. 2006 artículo científico 0873-2159 https://www.redalyc.org/articulo.oa?id=169718462001 en http://www.redalyc.org/revista.oa?id=1697 Revista Portuguesa de Pneumología application/pdf Sociedade Portuguesa de Pneumologia Revista Portuguesa de Pneumología (Portugal) Num.2 Vol.XII |
| format | Artículo científico |
| id | redalyc_169718462001 |
| institution | Redalyc |
| language | en |
| publishDate | 2006 |
| publisher | Sociedade Portuguesa de Pneumologia |
| spellingShingle | Involvement of central airways in vibroacoustic disease patients José Reis Ferreira Medicina auto mecano displasia apoptosis transduction Involvement of central airways in vibroacoustic disease patients José Reis Ferreira Miguel B Monteiro Fernanda Tavares Isabel Serrano Emanuel Monteiro Carla P Mendes Mariana Alves-Pereira Nuno A A Castelo Branco Medicina auto mecano displasia apoptosis transduction Introduction. Vibroacoustic disease (VAD) is the whole-body pathology caused by excessive exposure to LFN. For the past 25 years, it has been know that low frequency noise (LFN, <500 Hz, including infrasound) targets the respiratory system. In LFN-exposed rodents, the morphological changes of respiratory tract tissue partially explained some respiratory symptoms reported by VAD patients. However, many questions remain unanswered. Recently, some volunteer VAD patients underwent bronchoscopy in order to ascertain possible damage that could be associated with their respiratory complaints. Methods. Fourteen fully-informed and volunteer VAD patients were submitted to bronchoscopy, and biopsies were removed for analysis. Results. All patients exhibited small submucosal vascular-like lesions near the spurs, consisting of increased collagen and elastin fibres. Histology disclosed cilliary abnormalities, basal membrane hyperplasia, and thickening of vessel walls. In five patients, collagen bundles appeared degenerative and disrupted. No inflammatory process was ever identified, and no differences were seen between smokers and non-smokers. Discussion. Data is in accordance with what was observed in LFN-exposed animal models and also in 8 VAD patients who developed lung tumours. Collagen disruption and degeneration was also observed in electron microscopy images of the respiratory tract of LFN-exposed rodents. Thickened blood and lymphatic vessel walls have been consistently seen in images of VAD patients and of LFN-exposed rodents. During bronchoscopy performed by other reasons, this sort of structural aspects is not frequently seen. Taken together, it is strongly suggested that these findings could be VAD-specific. 2006 artículo científico 0873-2159 https://www.redalyc.org/articulo.oa?id=169718462001 en http://www.redalyc.org/revista.oa?id=1697 Revista Portuguesa de Pneumología application/pdf Sociedade Portuguesa de Pneumologia Revista Portuguesa de Pneumología (Portugal) Num.2 Vol.XII |
| title | Involvement of central airways in vibroacoustic disease patients |
| topic | Medicina auto mecano displasia apoptosis transduction |
| url | https://www.redalyc.org/articulo.oa?id=169718462001 |