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| Format: | Artículo científico |
| Langue: | en |
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Sociedade Portuguesa de Pneumologia
2015
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| Accès en ligne: | https://www.redalyc.org/articulo.oa?id=169737162005 |
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| _version_ | 1866815802774126592 |
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| author | Sílvia Correia |
| author_facet | Sílvia Correia |
| contents | Clinical impact of adaptive servoventilation compared to other ventilatory modes in patients with treatment-emergent sleep apnea, central sleep apnea and Cheyne-Stokes respiration Sílvia Correia Vitória Martins Liliana Sousa Joaquim Moita Fátima Teixeira José Moutinho dos Santos Medicina ASV CSA CSR emergent Treatment Introduction: Adaptive servoventilation is a recent ventilatory mode initially designed to treat Cheyne---Stokes respiration (CSR). Recently, the efficacy of ASV has been discussed for the treatment of central sleep apnea (CSA) and treatment-emergent central sleep apnea (treatment-emergent CSA) where other forms of traditional positive airway pressure (PAP) may be insufficient. Objectives: To compare the clinical impact of ASV with other forms of PAP in treating patients with treatment-emergent CSA, CSA and CSR. Methods: Medical data of all the patients who underwent polysomnography (PSG) with ASV titration were evaluated. The patients were divided into two groups according to the mode of ventilation reimbursed: ASV and PAP (AutoCPAP/CPAP/BIPAP). All patients had a minimal follow-up of 6 months. Both groups were compared in terms of symptoms, apnea hypopnea index, compliance, cardiac function and cardiovascular events. Results: ASV titration was performed in 33 patients (30M/3F) with a mean age of 69 ± 8 years. The majority (58%) present a treatment-emergent SA and 42% a CSA and or CSR. The median initial diagnostic AHI was 46 ± 22 events/h. After the initial diagnosis, 28 patients were treated with PAP and 5 with servoventilation. All of the patients treated with PAP were posteriorly submitted to PSG and ASV titration because of suboptimal response to PAP. Despite a clear indication for ASV, due to differences in reimbursement, 15 patients continued treatment with PAP (12 with AutoCPAP, 1 with BIPAP and 2 with CPAP) and 16 changed to ASV. Two patients were lost in follow-up.In both groups, most of patients present a treatment-emergent SA (53% in ASV group vs. 67% in PAP group) or a CSA/CSR (29.4% in ASV group vs. 20% in PAP). After ASV titration, the mean follow-up was 25 ± 14 months. Both groups (ASV vs. PAP) were similar in terms of compliance (77 ± 23% vs.88 ± 14%) and in terms of Epworth sleepiness scale score (6 ± 5 vs. 7 ± 5). There was a statistical difference in terms of residual AHI: mean AHI was 4 ± 3 in ASV group and 9 ± 3 in PAP group (P = 0.005). We found no differences in terms of left ventricular fractional shortening (ASV 33 ± 10% vs. PAP 32 ± 10%). Although no difference was observed between the 2 groups in terms of non-fatal cardiovascular events (3 events in each group), 2 fatal cardiovascular events occurred in the PAP group (sudden death). Conclusions: These data confirm that ASV is an efficient treatment in patients with treatmentemergent CSA, CSA/CSR significantly decreasing residual AHI. In both groups, compliance rate was high and sleepiness improved. It is relevant that the 2 patients who died of sudden death were treated with PAP. © 2014 Sociedade Portuguesa de Pneumologia. Published by Elsevier España, S.L.U. All rights reserved. 2015 artículo científico 0873-2159 https://www.redalyc.org/articulo.oa?id=169737162005 en http://www.redalyc.org/revista.oa?id=1697 Revista Portuguesa de Pneumología application/pdf Sociedade Portuguesa de Pneumologia Revista Portuguesa de Pneumología (Portugal) Num.3 Vol.21 |
| format | Artículo científico |
| id | redalyc_169737162005 |
| language | en |
| publishDate | 2015 |
| publisher | Sociedade Portuguesa de Pneumologia |
| spellingShingle | Clinical impact of adaptive servoventilation compared to other ventilatory modes in patients with treatment-emergent sleep apnea, central sleep apnea and Cheyne-Stokes respiration Sílvia Correia Medicina ASV CSA CSR emergent Treatment Clinical impact of adaptive servoventilation compared to other ventilatory modes in patients with treatment-emergent sleep apnea, central sleep apnea and Cheyne-Stokes respiration Sílvia Correia Vitória Martins Liliana Sousa Joaquim Moita Fátima Teixeira José Moutinho dos Santos Medicina ASV CSA CSR emergent Treatment Introduction: Adaptive servoventilation is a recent ventilatory mode initially designed to treat Cheyne---Stokes respiration (CSR). Recently, the efficacy of ASV has been discussed for the treatment of central sleep apnea (CSA) and treatment-emergent central sleep apnea (treatment-emergent CSA) where other forms of traditional positive airway pressure (PAP) may be insufficient. Objectives: To compare the clinical impact of ASV with other forms of PAP in treating patients with treatment-emergent CSA, CSA and CSR. Methods: Medical data of all the patients who underwent polysomnography (PSG) with ASV titration were evaluated. The patients were divided into two groups according to the mode of ventilation reimbursed: ASV and PAP (AutoCPAP/CPAP/BIPAP). All patients had a minimal follow-up of 6 months. Both groups were compared in terms of symptoms, apnea hypopnea index, compliance, cardiac function and cardiovascular events. Results: ASV titration was performed in 33 patients (30M/3F) with a mean age of 69 ± 8 years. The majority (58%) present a treatment-emergent SA and 42% a CSA and or CSR. The median initial diagnostic AHI was 46 ± 22 events/h. After the initial diagnosis, 28 patients were treated with PAP and 5 with servoventilation. All of the patients treated with PAP were posteriorly submitted to PSG and ASV titration because of suboptimal response to PAP. Despite a clear indication for ASV, due to differences in reimbursement, 15 patients continued treatment with PAP (12 with AutoCPAP, 1 with BIPAP and 2 with CPAP) and 16 changed to ASV. Two patients were lost in follow-up.In both groups, most of patients present a treatment-emergent SA (53% in ASV group vs. 67% in PAP group) or a CSA/CSR (29.4% in ASV group vs. 20% in PAP). After ASV titration, the mean follow-up was 25 ± 14 months. Both groups (ASV vs. PAP) were similar in terms of compliance (77 ± 23% vs.88 ± 14%) and in terms of Epworth sleepiness scale score (6 ± 5 vs. 7 ± 5). There was a statistical difference in terms of residual AHI: mean AHI was 4 ± 3 in ASV group and 9 ± 3 in PAP group (P = 0.005). We found no differences in terms of left ventricular fractional shortening (ASV 33 ± 10% vs. PAP 32 ± 10%). Although no difference was observed between the 2 groups in terms of non-fatal cardiovascular events (3 events in each group), 2 fatal cardiovascular events occurred in the PAP group (sudden death). Conclusions: These data confirm that ASV is an efficient treatment in patients with treatmentemergent CSA, CSA/CSR significantly decreasing residual AHI. In both groups, compliance rate was high and sleepiness improved. It is relevant that the 2 patients who died of sudden death were treated with PAP. © 2014 Sociedade Portuguesa de Pneumologia. Published by Elsevier España, S.L.U. All rights reserved. 2015 artículo científico 0873-2159 https://www.redalyc.org/articulo.oa?id=169737162005 en http://www.redalyc.org/revista.oa?id=1697 Revista Portuguesa de Pneumología application/pdf Sociedade Portuguesa de Pneumologia Revista Portuguesa de Pneumología (Portugal) Num.3 Vol.21 |
| title | Clinical impact of adaptive servoventilation compared to other ventilatory modes in patients with treatment-emergent sleep apnea, central sleep apnea and Cheyne-Stokes respiration |
| topic | Medicina ASV CSA CSR emergent Treatment |
| url | https://www.redalyc.org/articulo.oa?id=169737162005 |