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| Format: | Artículo científico |
| Language: | en |
| Published: |
Sociedade Portuguesa de Pneumologia
2017
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| Online Access: | https://www.redalyc.org/articulo.oa?id=169750820004 |
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Table of Contents:
- Ventilation distribution and small airway function in patients with systemic sclerosis B.R.A. Silva R. Rufino C.H. Costa V.S. Vilela R.A. Levy A.J. Lopes Medicina Background: Despite the importance of traditional pulmonary function tests (PFTs) in manag- ing systemic sclerosis (SSc), many patients with pulmonary disease diagnosed by computed tomography (CT) present with normal PFTs. Objective: To evaluate the efficacy of the nitrogen single-breath washout (N 2 SBW) test in diag- nosing SSc and to correlate N 2 SBW parameters with the PFT indexes used in the follow-up of these patients, clinical data, and CT findings. Methods: Cross-sectional study in which 52 consecutive SSc patients were subjected to spirom- etry, body plethysmography, analysis of the diffusing capacity for carbon monoxide (DLCO), analysis of respiratory muscle strength, N 2 SBW testing, and CT analysis. Results: Twenty-eight patients had a forced vital capacity (FVC) that was <70% of the predicted value. In the N 2 SBW test, 44 patients had a phase III slope (Phase III slope N2SBW ) that was >120% of the predicted value, while 15 patients had a closing volume/vital capacity (CV/VC) that was >120% of the predicted value. A significant difference in Phase III slope N2SBW was observed when the patients with predominant traction bronchiectasis and honeycombing were compared to the patients with other CT patterns ( p < 0.0001). The Phase III slope N2SBW was correlated with FVC ( r s = − 0.845, p < 0.0001) and DLCO ( r s = − 0.600, p < 0.0001), and the CV/VC was correlated with FVC ( r s = − 0.460, p = 0.0006) and residual volume/total lung capacity ( r s = 0.328, p = 0.017).Conclusion: Ventilation heterogeneity is a frequent finding in SSc patients that is associated with restrictive damage, changes in pulmonary diffusion, and CT patterns. In addition, approxi- mately one-third of the patients presented with findings that were compatible with small airway disease. 2017 artículo científico 0873-2159 https://www.redalyc.org/articulo.oa?id=169750820004 en http://www.redalyc.org/revista.oa?id=1697 Revista Portuguesa de Pneumología application/pdf Sociedade Portuguesa de Pneumologia Revista Portuguesa de Pneumología (Portugal) Num.3 Vol.23