Insertion/deletion polymorphism of the angiotensin converting enzyme gene and acute myocardial infarction. A case-control study in Venezuela
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| Format: | Artículo científico |
| Sprache: | en |
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Sociedad Latinoamericana de Hipertensión
2010
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| _version_ | 1876458644640366592 |
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| author | Carolina Pestana |
| author_facet | Carolina Pestana |
| contents | Insertion/deletion polymorphism of the angiotensin converting enzyme gene and acute myocardial infarction. A case-control study in Venezuela Carolina Pestana Antonietta Porco Mary Lares Sara Brito Medicina AMI ACE gene D polymorphism angiotensin II Objective: Detection of the ACE I/D polymorphism genotype and the association with essential hypertension and acute myocardial infarction (AMI) in the Venezuelan population. Methods: Samples from 200 patients with AMI and 200 control subjects were analyzed for genotyping ACE I/D polymorphism. A subset of 82 samples underwent the determination of angiotensin II levels (pg/ml). Results: The frequency for the heterozygous ID was 52.50% vs 44.50% and 26.50% vs 36.00% for DD homozygous individuals for AMI and control groups respectively. The D allele frequency was very similar for both populations (0.535 for AMI vs 0.583 for control subjects). The OR for AMI in carriers for the D allele was 0.91 (95% CI: 0.54- 1.53, p>0.05). We found a 2.66 fold increased risk between individuals belonging to the AMI group (OR= 2.66, 95% CI: 1.33-5.31, p<0.05) and an 8.46 fold increased risk for AMI in hypertensive individuals (OR=8.46, 95% CI: 5.24-1368; p<0.05). Finally, we detected a statistically significant difference in angiotensin II levels between individuals with DD and II genotypes (6.59±2.93 pg/ml DD genotype vs 4.26±1.40 pg/ml II genotype, p<0.05).Conclusions: We did not find the ACE genotype as a marker for AMI; but we found at statistically significant increased risk between hypertensive individuals carrying the D allele belonging to the AMI group. The lack of direct association between D risk allele and the AMI could be due to the well known multifactorial nature of this pathology. 2010 artículo científico 1856-4550 https://www.redalyc.org/articulo.oa?id=170216844003 en http://www.redalyc.org/revista.oa?id=1702 Revista Latinoamericana de Hipertensión application/pdf Sociedad Latinoamericana de Hipertensión Revista Latinoamericana de Hipertensión (República Bolivariana de Venezuela) Num.3 Vol.5 |
| format | Artículo científico |
| id | redalyc_170216844003 |
| institution | Redalyc |
| language | en |
| publishDate | 2010 |
| publisher | Sociedad Latinoamericana de Hipertensión |
| spellingShingle | Insertion/deletion polymorphism of the angiotensin converting enzyme gene and acute myocardial infarction. A case-control study in Venezuela Carolina Pestana Medicina AMI ACE gene D polymorphism angiotensin II Insertion/deletion polymorphism of the angiotensin converting enzyme gene and acute myocardial infarction. A case-control study in Venezuela Carolina Pestana Antonietta Porco Mary Lares Sara Brito Medicina AMI ACE gene D polymorphism angiotensin II Objective: Detection of the ACE I/D polymorphism genotype and the association with essential hypertension and acute myocardial infarction (AMI) in the Venezuelan population. Methods: Samples from 200 patients with AMI and 200 control subjects were analyzed for genotyping ACE I/D polymorphism. A subset of 82 samples underwent the determination of angiotensin II levels (pg/ml). Results: The frequency for the heterozygous ID was 52.50% vs 44.50% and 26.50% vs 36.00% for DD homozygous individuals for AMI and control groups respectively. The D allele frequency was very similar for both populations (0.535 for AMI vs 0.583 for control subjects). The OR for AMI in carriers for the D allele was 0.91 (95% CI: 0.54- 1.53, p>0.05). We found a 2.66 fold increased risk between individuals belonging to the AMI group (OR= 2.66, 95% CI: 1.33-5.31, p<0.05) and an 8.46 fold increased risk for AMI in hypertensive individuals (OR=8.46, 95% CI: 5.24-1368; p<0.05). Finally, we detected a statistically significant difference in angiotensin II levels between individuals with DD and II genotypes (6.59±2.93 pg/ml DD genotype vs 4.26±1.40 pg/ml II genotype, p<0.05).Conclusions: We did not find the ACE genotype as a marker for AMI; but we found at statistically significant increased risk between hypertensive individuals carrying the D allele belonging to the AMI group. The lack of direct association between D risk allele and the AMI could be due to the well known multifactorial nature of this pathology. 2010 artículo científico 1856-4550 https://www.redalyc.org/articulo.oa?id=170216844003 en http://www.redalyc.org/revista.oa?id=1702 Revista Latinoamericana de Hipertensión application/pdf Sociedad Latinoamericana de Hipertensión Revista Latinoamericana de Hipertensión (República Bolivariana de Venezuela) Num.3 Vol.5 |
| title | Insertion/deletion polymorphism of the angiotensin converting enzyme gene and acute myocardial infarction. A case-control study in Venezuela |
| topic | Medicina AMI ACE gene D polymorphism angiotensin II |
| url | https://www.redalyc.org/articulo.oa?id=170216844003 |