Increased levels of Lp(a) are related with family risk factors of CVD in children and adolescents from Maracaibo (Venezuela)
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| Formato: | Artículo científico |
| Lenguaje: | en |
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Sociedad Latinoamericana de Hipertensión
2007
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| _version_ | 1876424150314123264 |
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| author | Aida Souki-Rincón |
| author_facet | Aida Souki-Rincón |
| contents | Increased levels of Lp(a) are related with family risk factors of CVD in children and adolescents from Maracaibo (Venezuela) Aida Souki-Rincón Yaneth Urdaneta Edgardo Mengual Valmore Bermúdez-Pirela Luis Sorell Clímaco Cano-Ponce Medicina Lpa children adolescents risk factors Objective: The aim of the study was to determine Lipoprotein (a) (Lp(a)) concentrations in a sample of subjects from Maracaibo (Venezuela) and to find out the relationship of family risk factors for cardiovascular disease and their Lipoprotein(a) levels. Methods: 227 healthy individuals between 5 and 19 years f age, of both genders and multi-ethnic origins were selected. A complete background clinical chart and laboratory test was made for each patient in order to discard cardiovascular diseases and confirm their healthy state. The Lp (a) concentration was determined using the double antibody ELISA method. For inferential statistical analysis one factor ANOVA tests and "t" student test for independent observations were used according to each case, considered significant when p value was <0.05. Results: No significant differences were observed when evaluating Lipoprotein (a) levels according to sex in all ages. Males showed no significant difference in Lipoprotein (a) levels between groups but, in females a significant lower level (p<0.03) in the group of 5-9 years was found. When considering only age, significant lower levels were observed (p<0.03) in the 5-9 years old group. When studying family risk factors of cardiovascular diseases, it was found that group with family risk factors had a significantly higher Lipoprotein(a) concentration (p<0.01) than those without family¿s risk factors, observing that those who had 4 or more factors exhibited a significant higher concentration, than those with 2-3 risk factors (30.6±4.5 mg/dl vs 18.5±12.2 mg/dl, p<0.009) and than those with 1 risk factor (30.6±4.5 mg/dl vs 21.6±1.4 mg/dl, p<0,03) Conclusion: These results emphasize the clusters of family's risk factors of cardiovascular disease with higher Lp(a) levels and also indicate that the evaluation of its concentration should be taken as an independent risk factor of atherosclerosis for the population in developmental ages. 2007 artículo científico 1856-4550 https://www.redalyc.org/articulo.oa?id=170216979003 en http://www.redalyc.org/revista.oa?id=1702 Revista Latinoamericana de Hipertensión application/pdf Sociedad Latinoamericana de Hipertensión Revista Latinoamericana de Hipertensión (República Bolivariana de Venezuela) Num.4 Vol.2 |
| format | Artículo científico |
| id | redalyc_170216979003 |
| institution | Redalyc |
| language | en |
| publishDate | 2007 |
| publisher | Sociedad Latinoamericana de Hipertensión |
| spellingShingle | Increased levels of Lp(a) are related with family risk factors of CVD in children and adolescents from Maracaibo (Venezuela) Aida Souki-Rincón Medicina Lpa children adolescents risk factors Increased levels of Lp(a) are related with family risk factors of CVD in children and adolescents from Maracaibo (Venezuela) Aida Souki-Rincón Yaneth Urdaneta Edgardo Mengual Valmore Bermúdez-Pirela Luis Sorell Clímaco Cano-Ponce Medicina Lpa children adolescents risk factors Objective: The aim of the study was to determine Lipoprotein (a) (Lp(a)) concentrations in a sample of subjects from Maracaibo (Venezuela) and to find out the relationship of family risk factors for cardiovascular disease and their Lipoprotein(a) levels. Methods: 227 healthy individuals between 5 and 19 years f age, of both genders and multi-ethnic origins were selected. A complete background clinical chart and laboratory test was made for each patient in order to discard cardiovascular diseases and confirm their healthy state. The Lp (a) concentration was determined using the double antibody ELISA method. For inferential statistical analysis one factor ANOVA tests and "t" student test for independent observations were used according to each case, considered significant when p value was <0.05. Results: No significant differences were observed when evaluating Lipoprotein (a) levels according to sex in all ages. Males showed no significant difference in Lipoprotein (a) levels between groups but, in females a significant lower level (p<0.03) in the group of 5-9 years was found. When considering only age, significant lower levels were observed (p<0.03) in the 5-9 years old group. When studying family risk factors of cardiovascular diseases, it was found that group with family risk factors had a significantly higher Lipoprotein(a) concentration (p<0.01) than those without family¿s risk factors, observing that those who had 4 or more factors exhibited a significant higher concentration, than those with 2-3 risk factors (30.6±4.5 mg/dl vs 18.5±12.2 mg/dl, p<0.009) and than those with 1 risk factor (30.6±4.5 mg/dl vs 21.6±1.4 mg/dl, p<0,03) Conclusion: These results emphasize the clusters of family's risk factors of cardiovascular disease with higher Lp(a) levels and also indicate that the evaluation of its concentration should be taken as an independent risk factor of atherosclerosis for the population in developmental ages. 2007 artículo científico 1856-4550 https://www.redalyc.org/articulo.oa?id=170216979003 en http://www.redalyc.org/revista.oa?id=1702 Revista Latinoamericana de Hipertensión application/pdf Sociedad Latinoamericana de Hipertensión Revista Latinoamericana de Hipertensión (República Bolivariana de Venezuela) Num.4 Vol.2 |
| title | Increased levels of Lp(a) are related with family risk factors of CVD in children and adolescents from Maracaibo (Venezuela) |
| topic | Medicina Lpa children adolescents risk factors |
| url | https://www.redalyc.org/articulo.oa?id=170216979003 |