Molecular mechanisms of Endothelial Dysfunction: from the nitric oxide synthesis to ADMA inhibition
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| Format: | Artículo científico |
| Language: | en |
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Sociedad Latinoamericana de Hipertensión
2007
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| author | Valmore Bermúdez |
| author_facet | Valmore Bermúdez |
| contents | Molecular mechanisms of Endothelial Dysfunction: from the nitric oxide synthesis to ADMA inhibition Valmore Bermúdez Fernando Bermúdez Guillermo Acosta Alejandro Acosta Johnny Añez Carla Andara Elliuz Leal Clímaco Cano Manuel Velasco Rafael Hernández Israili Zafar Medicina Nitric Oxide Nitric Oxide Synthase Endothelial Dysfunction Cardiovascular Diseases Endothelial dysfunction symbolize several pathological conditions, including altered anticoagulant and anti-inflammatory properties of the endothelium, impaired modulation of vascular growth, and dysregulation of vascular remodeling. Nevertheless, this term has been used commonly to refer to an impairment of endothelium-dependent vasorelaxation caused by a loss of nitric oxide bioactivity. The clinical and scientific relevance of Nitric Oxide synthesis and bioavailability in endothelial dysfunction is based on the fact that it is a common factor in the pathogenesis of cardiovascular diseases. These alterations have been demonstrated in both animal models and humans, in the scope of dangerous pathological conditions as cigarette smoking, hypertension, hypercholesterolemia, aging, diabetes and heart failure. A decline in Nitric Oxide bioavailability may be caused by decreased expression of the endothelial NO synthase, a reduction of substrate or cofactors for this enzyme, alterations of cellular signaling, enzyme inhibition by asymmetric dimethyl arginine and, finally, accelerated Nitric Oxide degradation by reactive oxygen species. The knowledge of the processes related to these alterations becomes of remarkable importance for the understanding and of the generation of innovating and effective therapeutic strategies for cardiovascular diseases. 2007 artículo científico 1856-4550 https://www.redalyc.org/articulo.oa?id=170216980004 en http://www.redalyc.org/revista.oa?id=1702 Revista Latinoamericana de Hipertensión application/pdf Sociedad Latinoamericana de Hipertensión Revista Latinoamericana de Hipertensión (República Bolivariana de Venezuela) Num.3 Vol.2 |
| format | Artículo científico |
| id | redalyc_170216980004 |
| institution | Redalyc |
| language | en |
| publishDate | 2007 |
| publisher | Sociedad Latinoamericana de Hipertensión |
| spellingShingle | Molecular mechanisms of Endothelial Dysfunction: from the nitric oxide synthesis to ADMA inhibition Valmore Bermúdez Medicina Nitric Oxide Nitric Oxide Synthase Endothelial Dysfunction Cardiovascular Diseases Molecular mechanisms of Endothelial Dysfunction: from the nitric oxide synthesis to ADMA inhibition Valmore Bermúdez Fernando Bermúdez Guillermo Acosta Alejandro Acosta Johnny Añez Carla Andara Elliuz Leal Clímaco Cano Manuel Velasco Rafael Hernández Israili Zafar Medicina Nitric Oxide Nitric Oxide Synthase Endothelial Dysfunction Cardiovascular Diseases Endothelial dysfunction symbolize several pathological conditions, including altered anticoagulant and anti-inflammatory properties of the endothelium, impaired modulation of vascular growth, and dysregulation of vascular remodeling. Nevertheless, this term has been used commonly to refer to an impairment of endothelium-dependent vasorelaxation caused by a loss of nitric oxide bioactivity. The clinical and scientific relevance of Nitric Oxide synthesis and bioavailability in endothelial dysfunction is based on the fact that it is a common factor in the pathogenesis of cardiovascular diseases. These alterations have been demonstrated in both animal models and humans, in the scope of dangerous pathological conditions as cigarette smoking, hypertension, hypercholesterolemia, aging, diabetes and heart failure. A decline in Nitric Oxide bioavailability may be caused by decreased expression of the endothelial NO synthase, a reduction of substrate or cofactors for this enzyme, alterations of cellular signaling, enzyme inhibition by asymmetric dimethyl arginine and, finally, accelerated Nitric Oxide degradation by reactive oxygen species. The knowledge of the processes related to these alterations becomes of remarkable importance for the understanding and of the generation of innovating and effective therapeutic strategies for cardiovascular diseases. 2007 artículo científico 1856-4550 https://www.redalyc.org/articulo.oa?id=170216980004 en http://www.redalyc.org/revista.oa?id=1702 Revista Latinoamericana de Hipertensión application/pdf Sociedad Latinoamericana de Hipertensión Revista Latinoamericana de Hipertensión (República Bolivariana de Venezuela) Num.3 Vol.2 |
| title | Molecular mechanisms of Endothelial Dysfunction: from the nitric oxide synthesis to ADMA inhibition |
| topic | Medicina Nitric Oxide Nitric Oxide Synthase Endothelial Dysfunction Cardiovascular Diseases |
| url | https://www.redalyc.org/articulo.oa?id=170216980004 |