The endothelial-to-mesenchyrnal transition process
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| Natura: | Artículo científico |
| Lingua: | en |
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Sociedad Latinoamericana de Hipertensión
2010
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| _version_ | 1876433767874166784 |
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| author | Luz Marina Carrillo P. |
| author_facet | Luz Marina Carrillo P. |
| contents | The endothelial-to-mesenchyrnal transition process Luz Marina Carrillo P. Enrique Arciniegas C. Medicina catenin endothelial growth factors intimal thickening vascular remodeling Endothelial-to-mesenchymal transition is a process through which certain endothelial cells lose endothelial characteristics and transform into mesenchymal cells or smooth muscle-like cells. Rapidly emerging data suggest that this process may have crucial roles during vascular development, cardiac fibrosis and intimal thickening formation observed in atherosclerosis and restenosis as well as in complex lesions associated with pulmonary hypertension, and during cancer progression. EndoMT entails growth factors and cytokines synthesis and secretion, activation of receptors, cytoskeleton reorganization, disassembly of the adherence junctions or 1055 of endothelial cell-cell contacts, change in cell shape and polarity, proteases secretion, extracellular matrix remodeling, cell- detachment and cell migration and differentiation. Here, we briefly review EndoMT keeping in mind that several questions still remain without answer. 2010 artículo científico 1856-4550 https://www.redalyc.org/articulo.oa?id=170217046002 en http://www.redalyc.org/revista.oa?id=1702 Revista Latinoamericana de Hipertensión application/pdf Sociedad Latinoamericana de Hipertensión Revista Latinoamericana de Hipertensión (República Bolivariana de Venezuela) Num.1 Vol.5 |
| format | Artículo científico |
| id | redalyc_170217046002 |
| institution | Redalyc |
| language | en |
| publishDate | 2010 |
| publisher | Sociedad Latinoamericana de Hipertensión |
| spellingShingle | The endothelial-to-mesenchyrnal transition process Luz Marina Carrillo P. Medicina catenin endothelial growth factors intimal thickening vascular remodeling The endothelial-to-mesenchyrnal transition process Luz Marina Carrillo P. Enrique Arciniegas C. Medicina catenin endothelial growth factors intimal thickening vascular remodeling Endothelial-to-mesenchymal transition is a process through which certain endothelial cells lose endothelial characteristics and transform into mesenchymal cells or smooth muscle-like cells. Rapidly emerging data suggest that this process may have crucial roles during vascular development, cardiac fibrosis and intimal thickening formation observed in atherosclerosis and restenosis as well as in complex lesions associated with pulmonary hypertension, and during cancer progression. EndoMT entails growth factors and cytokines synthesis and secretion, activation of receptors, cytoskeleton reorganization, disassembly of the adherence junctions or 1055 of endothelial cell-cell contacts, change in cell shape and polarity, proteases secretion, extracellular matrix remodeling, cell- detachment and cell migration and differentiation. Here, we briefly review EndoMT keeping in mind that several questions still remain without answer. 2010 artículo científico 1856-4550 https://www.redalyc.org/articulo.oa?id=170217046002 en http://www.redalyc.org/revista.oa?id=1702 Revista Latinoamericana de Hipertensión application/pdf Sociedad Latinoamericana de Hipertensión Revista Latinoamericana de Hipertensión (República Bolivariana de Venezuela) Num.1 Vol.5 |
| title | The endothelial-to-mesenchyrnal transition process |
| topic | Medicina catenin endothelial growth factors intimal thickening vascular remodeling |
| url | https://www.redalyc.org/articulo.oa?id=170217046002 |