New assessment of endothelium dependent flow-mediated vasodilation to characterize endothelium dysfunction
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| Formato: | Artículo científico |
| Lenguaje: | en |
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Sociedad Latinoamericana de Hipertensión
2006
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| _version_ | 1876473889649852416 |
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| author | Damian Craiem |
| author_facet | Damian Craiem |
| contents | New assessment of endothelium dependent flow-mediated vasodilation to characterize endothelium dysfunction Damian Craiem Gilles Chironi Alain Simon Jaime Levenson Medicina Age Endothelium Ultrasonography Flow mediated vasodilation The vascular endothelium plays an important role in the regulation of vascular tone, cell growth, inflammation and thrombogenicity. Endothelium dysfunction is then considered to promote several disorders that initiate the atherosclerosis process. The vascular tone dysfunction can be determined by high resolution ultrasonographic imaging of the brachial artery enabling to assess endothelium-dependent flow-mediated dilation (FMD). It is based on the principle that an increase in blood flow, specifically in shear stress, provokes the release of nitric oxide, and then a vasodilation that can be quantified. In this study, the brachial artery diameter evolution is continuously followed during baseline and hyperemia after forearm occlusion, using a custom designed software. Some techniques employed to measure FMD are limited by operator-dependence. We present a new automated and versatile method of flow-mediated vasodilation quantification based on B-mode echographic images and edge detection algorithms. Edges for each image in the acquired sequences are recognized as interfaces, based on the grey-level profiles of the averaged pixel values. Within-reading and within-subject FMD% coefficients of variation attainted 7% and 10% respectively. This technique largely improves manual measurements and shows to be appropriate for wide clinical use. 2006 artículo científico 1856-4550 https://www.redalyc.org/articulo.oa?id=170217084002 en http://www.redalyc.org/revista.oa?id=1702 Revista Latinoamericana de Hipertensión application/pdf Sociedad Latinoamericana de Hipertensión Revista Latinoamericana de Hipertensión (República Bolivariana de Venezuela) Num.4 Vol.1 |
| format | Artículo científico |
| id | redalyc_170217084002 |
| institution | Redalyc |
| language | en |
| publishDate | 2006 |
| publisher | Sociedad Latinoamericana de Hipertensión |
| spellingShingle | New assessment of endothelium dependent flow-mediated vasodilation to characterize endothelium dysfunction Damian Craiem Medicina Age Endothelium Ultrasonography Flow mediated vasodilation New assessment of endothelium dependent flow-mediated vasodilation to characterize endothelium dysfunction Damian Craiem Gilles Chironi Alain Simon Jaime Levenson Medicina Age Endothelium Ultrasonography Flow mediated vasodilation The vascular endothelium plays an important role in the regulation of vascular tone, cell growth, inflammation and thrombogenicity. Endothelium dysfunction is then considered to promote several disorders that initiate the atherosclerosis process. The vascular tone dysfunction can be determined by high resolution ultrasonographic imaging of the brachial artery enabling to assess endothelium-dependent flow-mediated dilation (FMD). It is based on the principle that an increase in blood flow, specifically in shear stress, provokes the release of nitric oxide, and then a vasodilation that can be quantified. In this study, the brachial artery diameter evolution is continuously followed during baseline and hyperemia after forearm occlusion, using a custom designed software. Some techniques employed to measure FMD are limited by operator-dependence. We present a new automated and versatile method of flow-mediated vasodilation quantification based on B-mode echographic images and edge detection algorithms. Edges for each image in the acquired sequences are recognized as interfaces, based on the grey-level profiles of the averaged pixel values. Within-reading and within-subject FMD% coefficients of variation attainted 7% and 10% respectively. This technique largely improves manual measurements and shows to be appropriate for wide clinical use. 2006 artículo científico 1856-4550 https://www.redalyc.org/articulo.oa?id=170217084002 en http://www.redalyc.org/revista.oa?id=1702 Revista Latinoamericana de Hipertensión application/pdf Sociedad Latinoamericana de Hipertensión Revista Latinoamericana de Hipertensión (República Bolivariana de Venezuela) Num.4 Vol.1 |
| title | New assessment of endothelium dependent flow-mediated vasodilation to characterize endothelium dysfunction |
| topic | Medicina Age Endothelium Ultrasonography Flow mediated vasodilation |
| url | https://www.redalyc.org/articulo.oa?id=170217084002 |