Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Artículo científico |
| Sprache: | en |
| Veröffentlicht: |
Sociedad Latinoamericana de Hipertensión
2019
|
| Schlagworte: | |
| Online-Zugang: | https://www.redalyc.org/articulo.oa?id=170262877009 https://www.redalyc.org/journal/1702/170262877009/ https://www.redalyc.org/journal/1702/170262877009/html/ https://www.redalyc.org/journal/1702/170262877009/170262877009.epub https://www.redalyc.org/journal/1702/170262877009/movil |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Inhaltsangabe:
- Seromarkers of synthesis and collagen degradation, electrophysiological heart parameters among patients with syndrome of preexcitation of ventricles L. M. Vasilets A. A. Krivaya V. V Vustina O. V. Khlynova L. A. Nekrutenko A. V. Tuev Medicina Arrhythmia arrhythmogenesis markersof fibrosis The results of examination of 43 patients with syndrome of preexcitation of ventricles are introduced in the article. The aim of the study was to optimize diagnostics and prediction of the development of arrhythmia in this cohort and to find out the possible role of disorder of fibrous matrix in the development of disorder of cardiac arrhythmias. The main group consisted of 43 patients with syndrome of preexcitation of ventricles (phenomenon WPW, syndrome WPW) and 15 practically healthy people of the same age were in the group of comparison. The average age of the examined patients from the main group was 25,3±9,15 years old, among them 29 men (67%) and 14 women (33%). The average age in the comparison group was 27,9±7,9 years old. All groups included into the examination were comparable by gender distribution (р=0,45, Fisher's test) and by age (р=0,27, U-criterion). The highest figures of matrix metal proteinase-9 (MMP-9) were found among patients with syndrome WPW – 96,1±33,2ng/ml and in the group of phenomenon WPW (54,3±21,8ng/ml; р=0,0003). Practically healthy people had minimal values of the MMP-9 - 27,4±10,9ng/ml (р=0,00014; р=0,000002). Maximal values of tissue inhibitor of matrix metal proteinase (TIMP-1) are introduced in the group of phenomenon WPW and in the group of practically healthy people (418,5±69,8 ng/ml and 461,7±72,2ng/ml; р=0,27). Patients with syndrome WPW have lower TIMP-1 – 341,1±90,1 ng/ml (р=0,002; р=0,00012). The level of propeptideprocollagenof the type I(PICP) among patients with syndrome WPW was 179,9±76,2ng/ml and 97,8±31,7 ng/ml (р=0,00014) in the group of phenomenon WPW. All examined patients according to the level of PICP differed from practically healthy people 69,4±23,9ng/ml (р<0,05, U-criterion). The examined patients have changes of fibrous matrix. That includes an increasing the concentration of MMP-9, PICP and reducing TIMP-1. The syndrome WPW is characterized by more expressed disbalanceof seromarkers of synthesis and collagen degradation than phenomenon is. It is possible that the examined seromarkers of fibrosis take place in forming disorders of cardiac arrhythmias in actual syndromes. 2019 artículo científico 1856-4550 https://www.redalyc.org/articulo.oa?id=170262877009 https://www.redalyc.org/journal/1702/170262877009/ https://www.redalyc.org/journal/1702/170262877009/html/ https://www.redalyc.org/journal/1702/170262877009/170262877009.epub https://www.redalyc.org/journal/1702/170262877009/movil en http://www.redalyc.org/revista.oa?id=1702 Revista Latinoamericana de Hipertensión application/pdf Sociedad Latinoamericana de Hipertensión Revista Latinoamericana de Hipertensión (República Bolivariana de Venezuela) Num.5 Vol.14