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| Format: | Artículo científico |
| Sprache: | en |
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Sociedad Latinoamericana de Hipertensión
2019
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| Online-Zugang: | https://www.redalyc.org/articulo.oa?id=170263176011 https://www.redalyc.org/journal/1702/170263176011/ https://www.redalyc.org/journal/1702/170263176011/html/ https://www.redalyc.org/journal/1702/170263176011/170263176011.epub https://www.redalyc.org/journal/1702/170263176011/movil |
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Inhaltsangabe:
- Analyzing indications of amniocentesis and positive predictive value (PPV) of cytogenetic findings of chromosomal abnormalities Nastaran Ali Akbari Khatereh Tooba Medicina Indication Amniocentesis Predictive value Genetic disorders Analysis of the causes and extent of initial diagnosis by invasive method of amniocentesis is very important in order to investigate the chromosomal abnormalities and other severe congenital defects to provide genetic counseling of pregnant women. In Ardebil province (northwest of Iran), due to failures such as infertility, repeated abortion and embryonic anomalies, a study was conducted to analyze amniotic fluid samples of pregnant mothers, to determine amniocentesis indications, to determine the frequency and types of chromosomal abnormalities and adaptability of indication of amniocentesis in pregnant women. This retrospective descriptive-analytic study was conducted on all amniocentesis files (715 referrals to the only Amniocentesis Center of Ardebil province) over 2 years. Data were collected by examining the patients' file. The variables included: maternal age, indication of amniocentesis, chromosomal anomalies, and type of chromosomal abnormalities. After completing the data, the data were analyzed using descriptive and analytical statistics in SPSS software version 16. Data analysis showed that the most common cause of amniocentesis was a positive result in maternal serum screening (58.04%). Chromosomal abnormalities were observed in 5.5%. 56.4% of chromosomal abnormalities were the type of change in number (including trisomy 21) and 35.9% were the structural type. The inversion of chromosome No 9 was 33.3%. Among pregnant women, 78.7% had 1 indication, 20.6% had 2 indications, and 0.7% had 3 or 4 indications. The correlation between the results of amniotic fluid karyotype tests and serum tests was significant. The positive predictive value analysis showed that the more the number of indications is more; the positive predictive value tends to be maximized. Investigating indications and results of embryonic amniocentesis samples in the present study indicates the importance of genetic screening for the identification of chromosomal abnormalities in 5.5% of pregnant women. The most common indication and the main chromosomal abnormalities detected with amniocentesis in our region are from positive result in maternal serum screening and trisomy 21, which is consistent with the latest findings in this area in other countries, respectively.The degree of adaptability of initial indication and the results of the amniocentesis genetic tests indicated that serum tests have undertaken a major contribution from the results for amniocentesis. In the analysis of indications, if the differentiation threshold regulated for invasive diagnostic tests is considered higher, probability of drift and the birth of babies with chromosomal defects will decrease. 2019 artículo científico 1856-4550 https://www.redalyc.org/articulo.oa?id=170263176011 https://www.redalyc.org/journal/1702/170263176011/ https://www.redalyc.org/journal/1702/170263176011/html/ https://www.redalyc.org/journal/1702/170263176011/170263176011.epub https://www.redalyc.org/journal/1702/170263176011/movil en http://www.redalyc.org/revista.oa?id=1702 Revista Latinoamericana de Hipertensión application/pdf Sociedad Latinoamericana de Hipertensión Revista Latinoamericana de Hipertensión (República Bolivariana de Venezuela) Num.3 Vol.14