Comparing cardiac asymmetric septal hypertrophy in hypothyroid patients before and after Levothyroxine therapy
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| Format: | Artículo científico |
| Sprache: | en |
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Sociedad Latinoamericana de Hipertensión
2020
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| _version_ | 1876462638563590144 |
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| author | Sajad Hassanzadeh |
| author_facet | Sajad Hassanzadeh |
| contents | Comparing cardiac asymmetric septal hypertrophy in hypothyroid patients before and after Levothyroxine therapy Sajad Hassanzadeh Mohammad Gholamnezhad Saeid jokar Farshad Fereidooni Medicina Hypertrophy Hypothyroid Patients Levothyroxine Therapy Asymmetrical septal hypertrophy (ASH) is the echocardiographic manifestation of hypertrophic cardiomyopathy (HCM). HCM is characterized by inappropriate left ventricle hypertrophy with preferential involvement of the interventricular symptom causing increased ventricular stiffness, which in turn results in diastolic dysfunction and dynamic left ventricular outflow tract pressure gradient. The study population included 65 newly diagnosed clinical hypothyroidism patients (52 female and 13 male with the mean age: 36.7±11.5), who were referred to endocrinology clinic of Shiraz University of Medical Sciences, Shiraz, Iran. All analyses were performed using SPSS for the window, version 15.0. Continuous variables are presented as mean±SD, while categorical variables are presented as percentage. The prevalence of ASH (IP ratio ≥1.3) was 20% (13 in 65 patients), which was statistically very significant (in relation to 0.2% seen in the total population). In the present study, we investigated the prevalence of ASH in clinical hypothyroidism and also myocardial systolic and diastolic parameter in these patients before and after the treatment. It is conceivable that hypothyroidism is associated with both global LV dysfunction and localized septal myocardial abnormality. Since the clinical significance of this reversible cardiomyopathy is unclear, routine echocardiograms are not indicated in hypothyroidism. However, any patient with hypothyroidism with symptoms of cardiovascular dysfunction (such as dyspnea, dizziness syncope, pericardial pain resembling angina pectoris) should undergo the echocardiographic examination to exclude HCM. 2020 artículo científico 1856-4550 https://www.redalyc.org/articulo.oa?id=170265473010 https://www.redalyc.org/journal/1702/170265473010/ https://www.redalyc.org/journal/1702/170265473010/html/ https://www.redalyc.org/journal/1702/170265473010/170265473010.epub https://www.redalyc.org/journal/1702/170265473010/movil https://doi.org/10.5281/zenodo.4074220 en http://www.redalyc.org/revista.oa?id=1702 Revista Latinoamericana de Hipertensión application/pdf Sociedad Latinoamericana de Hipertensión Revista Latinoamericana de Hipertensión (República Bolivariana de Venezuela) Num.1 Vol.15 |
| format | Artículo científico |
| id | redalyc_170265473010 |
| institution | Redalyc |
| language | en |
| publishDate | 2020 |
| publisher | Sociedad Latinoamericana de Hipertensión |
| spellingShingle | Comparing cardiac asymmetric septal hypertrophy in hypothyroid patients before and after Levothyroxine therapy Sajad Hassanzadeh Medicina Hypertrophy Hypothyroid Patients Levothyroxine Therapy Comparing cardiac asymmetric septal hypertrophy in hypothyroid patients before and after Levothyroxine therapy Sajad Hassanzadeh Mohammad Gholamnezhad Saeid jokar Farshad Fereidooni Medicina Hypertrophy Hypothyroid Patients Levothyroxine Therapy Asymmetrical septal hypertrophy (ASH) is the echocardiographic manifestation of hypertrophic cardiomyopathy (HCM). HCM is characterized by inappropriate left ventricle hypertrophy with preferential involvement of the interventricular symptom causing increased ventricular stiffness, which in turn results in diastolic dysfunction and dynamic left ventricular outflow tract pressure gradient. The study population included 65 newly diagnosed clinical hypothyroidism patients (52 female and 13 male with the mean age: 36.7±11.5), who were referred to endocrinology clinic of Shiraz University of Medical Sciences, Shiraz, Iran. All analyses were performed using SPSS for the window, version 15.0. Continuous variables are presented as mean±SD, while categorical variables are presented as percentage. The prevalence of ASH (IP ratio ≥1.3) was 20% (13 in 65 patients), which was statistically very significant (in relation to 0.2% seen in the total population). In the present study, we investigated the prevalence of ASH in clinical hypothyroidism and also myocardial systolic and diastolic parameter in these patients before and after the treatment. It is conceivable that hypothyroidism is associated with both global LV dysfunction and localized septal myocardial abnormality. Since the clinical significance of this reversible cardiomyopathy is unclear, routine echocardiograms are not indicated in hypothyroidism. However, any patient with hypothyroidism with symptoms of cardiovascular dysfunction (such as dyspnea, dizziness syncope, pericardial pain resembling angina pectoris) should undergo the echocardiographic examination to exclude HCM. 2020 artículo científico 1856-4550 https://www.redalyc.org/articulo.oa?id=170265473010 https://www.redalyc.org/journal/1702/170265473010/ https://www.redalyc.org/journal/1702/170265473010/html/ https://www.redalyc.org/journal/1702/170265473010/170265473010.epub https://www.redalyc.org/journal/1702/170265473010/movil https://doi.org/10.5281/zenodo.4074220 en http://www.redalyc.org/revista.oa?id=1702 Revista Latinoamericana de Hipertensión application/pdf Sociedad Latinoamericana de Hipertensión Revista Latinoamericana de Hipertensión (República Bolivariana de Venezuela) Num.1 Vol.15 |
| title | Comparing cardiac asymmetric septal hypertrophy in hypothyroid patients before and after Levothyroxine therapy |
| topic | Medicina Hypertrophy Hypothyroid Patients Levothyroxine Therapy |
| url | https://www.redalyc.org/articulo.oa?id=170265473010 https://www.redalyc.org/journal/1702/170265473010/ https://www.redalyc.org/journal/1702/170265473010/html/ https://www.redalyc.org/journal/1702/170265473010/170265473010.epub https://www.redalyc.org/journal/1702/170265473010/movil https://doi.org/10.5281/zenodo.4074220 |