Metanephrin-producing adrenocortical carcinoma: a case report
Fuente:
Redalyc
Salvato in:
| Autore principale: | |
|---|---|
| Natura: | Artículo científico |
| Lingua: | en |
| Pubblicazione: |
Sociedad Latinoamericana de Hipertensión
2021
|
| Soggetti: | |
| Accesso online: | |
| Tags: |
Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne!!
|
| _version_ | 1876425772454903808 |
|---|---|
| author | Laura González-Fernández |
| author_facet | Laura González-Fernández |
| contents | Metanephrin-producing adrenocortical carcinoma: a case report Laura González-Fernández Roberto José Añez-Ramos Alejandra Maricel Rivas-Montenegro Diego Muñoz Moreno Juan Carlos Percovich-Hualpa Medicina mitotane Metanephrine metanephrine pheochromocytoma mixed corticomedullar tumours Adrenocortical carcinoma is a rather infrequent neoplasm that mostly occurs with an autonomous secretion of steroids or steroid precursors. Previous cases have been reported with simultaneous production of metanephrines, but they were associated with intercurrent pheochromocytoma or mixed corticomedular tumors. So far, only two cases of adrenocortical carcinoma that deliver medullar hormones had been published. We herein report a singular case of a 58-year-old man with a finding of an incidental adrenal mass that demonstrated metanephrine production in the hormonal study. Consequently, initial diagnosis of pheochromocytoma was established. Microscopic examination showed an adrenal mass with marked pleomorphism and frequent mitosis. Large areas of coagulative necrosis were interspersed within the tumour. After immunohistochemistry staining there was a high expression of Ki67 (>70%) showing highly proliferative behaviour. Both cytokeratin AE1/AE3 and vimentin were positive, synaptophysin and chromogranin were negative. The surgical margins were free. Given these features, a diagnosis of metanephrin-producing adrenocortical carcinoma was done. 2021 artículo científico 1856-4550 https://www.redalyc.org/articulo.oa?id=170269310012 https://www.redalyc.org/journal/1702/170269310012/ https://www.redalyc.org/journal/1702/170269310012/html/ https://www.redalyc.org/journal/1702/170269310012/170269310012.epub https://www.redalyc.org/journal/1702/170269310012/movil https://doi.org/10.5281/zenodo.5514202 en http://www.redalyc.org/revista.oa?id=1702 Revista Latinoamericana de Hipertensión application/pdf Sociedad Latinoamericana de Hipertensión Revista Latinoamericana de Hipertensión (República Bolivariana de Venezuela) Num.2 Vol.16 |
| format | Artículo científico |
| id | redalyc_170269310012 |
| institution | Redalyc |
| language | en |
| publishDate | 2021 |
| publisher | Sociedad Latinoamericana de Hipertensión |
| spellingShingle | Metanephrin-producing adrenocortical carcinoma: a case report Laura González-Fernández Medicina mitotane Metanephrine metanephrine pheochromocytoma mixed corticomedullar tumours Metanephrin-producing adrenocortical carcinoma: a case report Laura González-Fernández Roberto José Añez-Ramos Alejandra Maricel Rivas-Montenegro Diego Muñoz Moreno Juan Carlos Percovich-Hualpa Medicina mitotane Metanephrine metanephrine pheochromocytoma mixed corticomedullar tumours Adrenocortical carcinoma is a rather infrequent neoplasm that mostly occurs with an autonomous secretion of steroids or steroid precursors. Previous cases have been reported with simultaneous production of metanephrines, but they were associated with intercurrent pheochromocytoma or mixed corticomedular tumors. So far, only two cases of adrenocortical carcinoma that deliver medullar hormones had been published. We herein report a singular case of a 58-year-old man with a finding of an incidental adrenal mass that demonstrated metanephrine production in the hormonal study. Consequently, initial diagnosis of pheochromocytoma was established. Microscopic examination showed an adrenal mass with marked pleomorphism and frequent mitosis. Large areas of coagulative necrosis were interspersed within the tumour. After immunohistochemistry staining there was a high expression of Ki67 (>70%) showing highly proliferative behaviour. Both cytokeratin AE1/AE3 and vimentin were positive, synaptophysin and chromogranin were negative. The surgical margins were free. Given these features, a diagnosis of metanephrin-producing adrenocortical carcinoma was done. 2021 artículo científico 1856-4550 https://www.redalyc.org/articulo.oa?id=170269310012 https://www.redalyc.org/journal/1702/170269310012/ https://www.redalyc.org/journal/1702/170269310012/html/ https://www.redalyc.org/journal/1702/170269310012/170269310012.epub https://www.redalyc.org/journal/1702/170269310012/movil https://doi.org/10.5281/zenodo.5514202 en http://www.redalyc.org/revista.oa?id=1702 Revista Latinoamericana de Hipertensión application/pdf Sociedad Latinoamericana de Hipertensión Revista Latinoamericana de Hipertensión (República Bolivariana de Venezuela) Num.2 Vol.16 |
| title | Metanephrin-producing adrenocortical carcinoma: a case report |
| topic | Medicina mitotane Metanephrine metanephrine pheochromocytoma mixed corticomedullar tumours |
| url | https://www.redalyc.org/articulo.oa?id=170269310012 https://www.redalyc.org/journal/1702/170269310012/ https://www.redalyc.org/journal/1702/170269310012/html/ https://www.redalyc.org/journal/1702/170269310012/170269310012.epub https://www.redalyc.org/journal/1702/170269310012/movil https://doi.org/10.5281/zenodo.5514202 |