Farmacocinética de la ampicilina en Alpacas (Lama pacos)
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| Format: | Artículo científico |
| Langue: | es |
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Universidad Austral de Chile
2001
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| _version_ | 1876464436765523968 |
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| author | V. KREIL |
| author_facet | V. KREIL |
| contents | Farmacocinética de la ampicilina en Alpacas (Lama pacos) V. KREIL C. LUDERS R. HALLU M. REBUELTO L. BETANCOURT Veterinaria alpacas ampicillin Pharmacokinetics southamerican camelids Ampicillin is a betalactamic antibiotic of frequent use in human and veterinary medicine. Ampicillin pharmacokinetics was determined in 6 alpacas after intravenous and intramuscular injection of 15 mg/kg body weight. Serum concentrations were obtained by the microbiologic method, usingBacillus subtilis ATCC 6633 as the test microorganism. Results best fitted to a two compartment model. The pharmacokinetic parameters were (mean ± standard deviation): t ½a = 0,14 ± 0,08 and 0,35 ± 0,12 h; t½b = 0,60 ± 0,20 and 0,79 ± 0,52 h; Vdss = 0,63 ± 0,05 and 0,80 ± 0,25l/kg; Cltotal = 15,96 ± 3,00 and 15,79 ± 2,89 ml/min/kg; AUC = 16,43 ± 3,44 and 17,22 ± 2,20 m g/ml*h for the i.v. and i.m routes, respectively. When administered by the i.m. route, t½a = 0,05 ± 0,01 h; Cmax = 18,38 ± 3,8 ug/ml and tmax = 0,16 ± 0,04 h. Bioavailability was 107 ± 20 %. Nosignificant differences were found between parameters obtained for both routes of administration.Ampicilin achieved serum concentrations above the minimun inhibitory concentrations (MIC) against many gram positive veterinary pathogens up to 3,.5 hours after administration, with a rapid andcomplete absorption from the injection site and a short elimination half life. 2001 artículo científico 0301-732X https://www.redalyc.org/articulo.oa?id=173013680013 es http://www.redalyc.org/revista.oa?id=1730 Archivos de Medicina Veterinaria application/pdf Universidad Austral de Chile Archivos de Medicina Veterinaria (Chile) Num.2 Vol.33 |
| format | Artículo científico |
| id | redalyc_173013680013 |
| institution | Redalyc |
| language | es |
| publishDate | 2001 |
| publisher | Universidad Austral de Chile |
| spellingShingle | Farmacocinética de la ampicilina en Alpacas (Lama pacos) V. KREIL Veterinaria alpacas ampicillin Pharmacokinetics southamerican camelids Farmacocinética de la ampicilina en Alpacas (Lama pacos) V. KREIL C. LUDERS R. HALLU M. REBUELTO L. BETANCOURT Veterinaria alpacas ampicillin Pharmacokinetics southamerican camelids Ampicillin is a betalactamic antibiotic of frequent use in human and veterinary medicine. Ampicillin pharmacokinetics was determined in 6 alpacas after intravenous and intramuscular injection of 15 mg/kg body weight. Serum concentrations were obtained by the microbiologic method, usingBacillus subtilis ATCC 6633 as the test microorganism. Results best fitted to a two compartment model. The pharmacokinetic parameters were (mean ± standard deviation): t ½a = 0,14 ± 0,08 and 0,35 ± 0,12 h; t½b = 0,60 ± 0,20 and 0,79 ± 0,52 h; Vdss = 0,63 ± 0,05 and 0,80 ± 0,25l/kg; Cltotal = 15,96 ± 3,00 and 15,79 ± 2,89 ml/min/kg; AUC = 16,43 ± 3,44 and 17,22 ± 2,20 m g/ml*h for the i.v. and i.m routes, respectively. When administered by the i.m. route, t½a = 0,05 ± 0,01 h; Cmax = 18,38 ± 3,8 ug/ml and tmax = 0,16 ± 0,04 h. Bioavailability was 107 ± 20 %. Nosignificant differences were found between parameters obtained for both routes of administration.Ampicilin achieved serum concentrations above the minimun inhibitory concentrations (MIC) against many gram positive veterinary pathogens up to 3,.5 hours after administration, with a rapid andcomplete absorption from the injection site and a short elimination half life. 2001 artículo científico 0301-732X https://www.redalyc.org/articulo.oa?id=173013680013 es http://www.redalyc.org/revista.oa?id=1730 Archivos de Medicina Veterinaria application/pdf Universidad Austral de Chile Archivos de Medicina Veterinaria (Chile) Num.2 Vol.33 |
| title | Farmacocinética de la ampicilina en Alpacas (Lama pacos) |
| topic | Veterinaria alpacas ampicillin Pharmacokinetics southamerican camelids |
| url | https://www.redalyc.org/articulo.oa?id=173013680013 |