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| Format: | Artículo científico |
| Sprache: | en |
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Universidade Estadual de Maringá
2019
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| Online-Zugang: | https://www.redalyc.org/articulo.oa?id=187160125040 https://www.redalyc.org/journal/1871/187160125040/ https://www.redalyc.org/journal/1871/187160125040/html/ https://www.redalyc.org/journal/1871/187160125040/187160125040.epub https://www.redalyc.org/journal/1871/187160125040/movil https://doi.org/10.4025/actascibiolsci.v41i1.46622 |
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Inhaltsangabe:
- Dalbergia ecastaphyllum leaf extracts: in vitro inhibitory potential against enzymes related to metabolic syndrome, inflammation and neurodegenerative diseases Daniel Vieira Morais Manuela Maria Moreira Fabiane de Lima Silva Maria Angélica Pereira de Carvalho Costa Cristina Delerue-Mato Carlos Alfredo Lopes Carvalho Maria Leticia Miranda Estevinho Biología glucosidase hyaluronidase Acetylcholinesterase preclinical research For the first time, the anti-hemolytic activity and the enzyme inhibitory activities of Dalbergia ecastaphyllum leaves extracts were tested against α-amylase, α-glucosidase, lipase, acetylcholinesterase, butyrylcholinesterase, tyrosinase and hyaluronidase. The phenolic profile of the obtained extracts was also investigated by high-performance liquid chromatography with photodiode array detection (HPLC-PAD). The extracts showed inhibitory activity against all enzymes evaluated, with the highest inhibitory activity reported for the enzyme hyaluronidase (28.28 ± 2.43 to 72.19 ± 1.40 μg mL-1). The obtained extracts also demonstrate anti-hemolytic activity (52.22 ± 1.62 to 71.17 ± 1.82%). Among the phenolic compounds identified, protocatechuic, vanillic and β-resorcylic acids were the most abundant (1.13 ± 0.06 to 2.53 ± 0.06, 0.90 ± 0.06 to 2.19 ± 0.06 and 1.03 ± 1.62 to 22.11 ± 1.62 mg L-1, respectively). In the statistical analysis, a significant correlation was found between the flavonoids content and all enzymes inhibitory activities. The present study showed that D. ecastaphyllum leaves extracts may have the potential to be used in the therapeutic treatment of several diseases such as Alzheimer, Parkinson, type 2 diabetes mellitus, hyperglycemia, and pigmentation, as well as those associated with oxidative stress. 2019 artículo científico 1679-9283 https://www.redalyc.org/articulo.oa?id=187160125040 https://www.redalyc.org/journal/1871/187160125040/ https://www.redalyc.org/journal/1871/187160125040/html/ https://www.redalyc.org/journal/1871/187160125040/187160125040.epub https://www.redalyc.org/journal/1871/187160125040/movil https://doi.org/10.4025/actascibiolsci.v41i1.46622 en http://www.redalyc.org/revista.oa?id=1871 Acta Scientiarum. Biological Sciences application/pdf Universidade Estadual de Maringá Acta Scientiarum. Biological Sciences (Brasil) Vol.41