Primary culture macrophages from fish as potential experimental model in toxicity studies with multiwalled carbon nanotubes
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| Natura: | Artículo científico |
| Lingua: | en |
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Universidade Estadual de Maringá
2021
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| _version_ | 1876489382663290880 |
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| author | Isabella Ferreira Silva |
| author_facet | Isabella Ferreira Silva |
| contents | Primary culture macrophages from fish as potential experimental model in toxicity studies with multiwalled carbon nanotubes Isabella Ferreira Silva Letícia Fagundes Papa Pedro Gontijo Carneiro Mariane Cristina Schnitzler Silmara Nunes Andrade Rosy Iara Maciel Azambuja Ribeiro Fernando Pilla Varotti Ralph Gruppi Thomé Hélio Batista Santos Biología liver spleen Nile tilapia Carbon nanotubes melanomacrophages Multiwalled carbon nanotube (MWCNT) has been broadly used in several sectors of society. This material when exposed to the environment might reach the aquatic animals and cause toxic effects. Here, it was evaluated the MWCNTs toxicity in melanomacrophages primary culture that was submitted to 1 µ gm L-1 MWCNTs for 24 hours. After exposition to MWCNT, 48 and 59% liver and spleen melanomacrophages were healthy, respectively. The control group presented 85% viability. Phagocytosis activity of melanomacrophages was observed by presence of black inclusions in cytoplasm. The findings indicate MWCNT was cytotoxic to melanomacrophages, where its release and effect into aquatic environment must be more studied. Finally, the melanomacrophages present large potential as experimental model for evaluation of carbon-based nanomaterial toxicity. 2021 artículo científico 1679-9283 https://www.redalyc.org/articulo.oa?id=187168668021 https://www.redalyc.org/journal/1871/187168668021/ https://www.redalyc.org/journal/1871/187168668021/html/ https://www.redalyc.org/journal/1871/187168668021/187168668021.epub https://www.redalyc.org/journal/1871/187168668021/movil https://doi.org/10.4025/actascibiolsci.v43i1.52612 en http://www.redalyc.org/revista.oa?id=1871 Acta Scientiarum. Biological Sciences application/pdf Universidade Estadual de Maringá Acta Scientiarum. Biological Sciences (Brasil) Vol.43 |
| format | Artículo científico |
| id | redalyc_187168668021 |
| institution | Redalyc |
| language | en |
| publishDate | 2021 |
| publisher | Universidade Estadual de Maringá |
| spellingShingle | Primary culture macrophages from fish as potential experimental model in toxicity studies with multiwalled carbon nanotubes Isabella Ferreira Silva Biología liver spleen Nile tilapia Carbon nanotubes melanomacrophages Primary culture macrophages from fish as potential experimental model in toxicity studies with multiwalled carbon nanotubes Isabella Ferreira Silva Letícia Fagundes Papa Pedro Gontijo Carneiro Mariane Cristina Schnitzler Silmara Nunes Andrade Rosy Iara Maciel Azambuja Ribeiro Fernando Pilla Varotti Ralph Gruppi Thomé Hélio Batista Santos Biología liver spleen Nile tilapia Carbon nanotubes melanomacrophages Multiwalled carbon nanotube (MWCNT) has been broadly used in several sectors of society. This material when exposed to the environment might reach the aquatic animals and cause toxic effects. Here, it was evaluated the MWCNTs toxicity in melanomacrophages primary culture that was submitted to 1 µ gm L-1 MWCNTs for 24 hours. After exposition to MWCNT, 48 and 59% liver and spleen melanomacrophages were healthy, respectively. The control group presented 85% viability. Phagocytosis activity of melanomacrophages was observed by presence of black inclusions in cytoplasm. The findings indicate MWCNT was cytotoxic to melanomacrophages, where its release and effect into aquatic environment must be more studied. Finally, the melanomacrophages present large potential as experimental model for evaluation of carbon-based nanomaterial toxicity. 2021 artículo científico 1679-9283 https://www.redalyc.org/articulo.oa?id=187168668021 https://www.redalyc.org/journal/1871/187168668021/ https://www.redalyc.org/journal/1871/187168668021/html/ https://www.redalyc.org/journal/1871/187168668021/187168668021.epub https://www.redalyc.org/journal/1871/187168668021/movil https://doi.org/10.4025/actascibiolsci.v43i1.52612 en http://www.redalyc.org/revista.oa?id=1871 Acta Scientiarum. Biological Sciences application/pdf Universidade Estadual de Maringá Acta Scientiarum. Biological Sciences (Brasil) Vol.43 |
| title | Primary culture macrophages from fish as potential experimental model in toxicity studies with multiwalled carbon nanotubes |
| topic | Biología liver spleen Nile tilapia Carbon nanotubes melanomacrophages |
| url | https://www.redalyc.org/articulo.oa?id=187168668021 https://www.redalyc.org/journal/1871/187168668021/ https://www.redalyc.org/journal/1871/187168668021/html/ https://www.redalyc.org/journal/1871/187168668021/187168668021.epub https://www.redalyc.org/journal/1871/187168668021/movil https://doi.org/10.4025/actascibiolsci.v43i1.52612 |