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| Format: | Artículo científico |
| Language: | es |
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Sociedad Argentina de Gastroenterología
2013
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| Online Access: | https://www.redalyc.org/articulo.oa?id=199329343012 |
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Table of Contents:
- Streptozotocin – induced diabetes, bile-pancreatic secretion and insulo-pancreon-axis interaction Osvaldo Manuel Tiscornia Ricardo Raúl Rodríguez Carlota Sussemil Graciela Otero Gustavo Alberto Negri Hipólito Waisman Fabiana Norma López Mingorance Patricia Graciela Tiscornia Wasserman Medicina Axis Insulo Secretin Pancreon Streptozotocine The present tests were undertaken in order to analyze in male Wistar rats the changes in the exocrine and endocrine pancreas and on the interactions that normally evolve in the insulo-pancreon-axis. To evaluate this by a single i.p. Boots secretin injection, glycemia (G), amylasemia (A) and lipa - semia (L) were determined. In bile-pancreatic secretion, we analyzed, pre and post-secretin, the following parameters: volume (V), bicarbonate output (BO), amylase output (AO) and lipase output (LO). Three groups of tests were done: a) control (C); b) streptozotocin-treated non-diabe - tic-rats (St-ND) and c) streptozotocin-treated diabetic ani - mals (St-D) which showed morning glycemia values higher than l6.0mmol/l. Four months later, under Tiopental i.p anesthesia, a bile-pancreatic fistula was done. Following a 30min basal period, Boots secretin (20CU/kg) was i.p injected. Bile-pancreatic secretion put in evidence a signifi - cant fall of BO in both St-ND and St-D series. In controls, AO revealed a post-secretin increase of 160%, while in the St-D rats showed a depression of 41%. The behavior of L was different, being augmented (+27%) in the C, while in the St-D rats the response was significantly higher (+95%). In bile-pancreatic-secretion, the fall of BO and AO in the St-ND and St- D series in respect to the C, are probably consequence of the diminishing potentiating effects exerted normally by insulin on the secretin-induced water and bi - carbonate secretion of the pancreon units. In contrast, the rising of LO in the St-D, an expression of an enhancing pancreocyte’s synthesis and secretion of lipase. The blood changes of A (depression) and of L (increase) in respect to the C values, although without reaching significant level, mirror those observed in bile-pancreatic secretion. 2013 artículo científico 2469-1119 https://www.redalyc.org/articulo.oa?id=199329343012 es http://www.redalyc.org/revista.oa?id=1993 Acta Gastroenterológica Latinoamericana application/pdf Sociedad Argentina de Gastroenterología Acta Gastroenterológica Latinoamericana (Argentina) Num.4 Vol.43