Early predictors of renal dysfunction in cirrhotic patients after liver transplantation
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| Formato: | Artículo científico |
| Lenguaje: | en |
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Sociedad Argentina de Gastroenterología
2014
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| _version_ | 1876445561860653056 |
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| author | Federico Piñero |
| author_facet | Federico Piñero |
| contents | Early predictors of renal dysfunction in cirrhotic patients after liver transplantation Federico Piñero Juan Bandi Paola Casciato Alejandra Villamil Omar Galdame Eduardo de Santibañés Adrián Gadano Matías Tisi Baña Medicina Cirrhosis renal failure immunosuppression liver transplantation Background. Assessment of renal function 12 months after liver transplantation (LT) predicts chronic renal failure on long-term follow up. Objective. To evaluate pre- and post- LT factors associated with development of renal dysfunction (RD) in cirrhotic patients. Methods. Between June 2005 and June 2010, 104 cirrhotic patients were selected from 268 consecutively transplanted adult patients. RD was de - fined as a calculated glomerular filtration rate (cGFR) < 50 ml/min/1.73m 2 by modification of diet in renal disease (MDRD), 12 months after LT. Results. Baseline pre-LT creatinine was 1.0 ± 0.7 mg/dL and cGFR was 64 ± 32.8 mL/min. At 12 month follow up, creatinine was 1.3 ± 0.6 mg/dL and cGFR was 47 ± 18 mL/min. The prevalence of RD was 55%. Variables related to RD on univariate analysis were age (P = 0.007), pre-LT GFR (P = 0.012) and 7th day post-LT GFR (P = 0.003). Risk factors associated with RD on multivariate stepwise regression analysis were patient age [Odds ratio (OR) 1.04 (95% confidence interval (CI) 0.99- 1.09, P = 0.06)] and 7 th day post-LT GFR [OR 0.97 (95% CI 0.96-0.99, P = 0.013)]. ROC curve analysis for 7 th day post-LT GFR was 0.71 (95% CI 0.61-0.81). Conclusion. The 7 th day post-LT GFR in cirrhotic patients may be a use - ful clinical tool to identify which patients might benefit from earlier nephroprotective immunosuppression. 2014 artículo científico 2469-1119 https://www.redalyc.org/articulo.oa?id=199333044010 en http://www.redalyc.org/revista.oa?id=1993 Acta Gastroenterológica Latinoamericana application/pdf Sociedad Argentina de Gastroenterología Acta Gastroenterológica Latinoamericana (Argentina) Num.4 Vol.44 |
| format | Artículo científico |
| id | redalyc_199333044010 |
| institution | Redalyc |
| language | en |
| publishDate | 2014 |
| publisher | Sociedad Argentina de Gastroenterología |
| spellingShingle | Early predictors of renal dysfunction in cirrhotic patients after liver transplantation Federico Piñero Medicina Cirrhosis renal failure immunosuppression liver transplantation Early predictors of renal dysfunction in cirrhotic patients after liver transplantation Federico Piñero Juan Bandi Paola Casciato Alejandra Villamil Omar Galdame Eduardo de Santibañés Adrián Gadano Matías Tisi Baña Medicina Cirrhosis renal failure immunosuppression liver transplantation Background. Assessment of renal function 12 months after liver transplantation (LT) predicts chronic renal failure on long-term follow up. Objective. To evaluate pre- and post- LT factors associated with development of renal dysfunction (RD) in cirrhotic patients. Methods. Between June 2005 and June 2010, 104 cirrhotic patients were selected from 268 consecutively transplanted adult patients. RD was de - fined as a calculated glomerular filtration rate (cGFR) < 50 ml/min/1.73m 2 by modification of diet in renal disease (MDRD), 12 months after LT. Results. Baseline pre-LT creatinine was 1.0 ± 0.7 mg/dL and cGFR was 64 ± 32.8 mL/min. At 12 month follow up, creatinine was 1.3 ± 0.6 mg/dL and cGFR was 47 ± 18 mL/min. The prevalence of RD was 55%. Variables related to RD on univariate analysis were age (P = 0.007), pre-LT GFR (P = 0.012) and 7th day post-LT GFR (P = 0.003). Risk factors associated with RD on multivariate stepwise regression analysis were patient age [Odds ratio (OR) 1.04 (95% confidence interval (CI) 0.99- 1.09, P = 0.06)] and 7 th day post-LT GFR [OR 0.97 (95% CI 0.96-0.99, P = 0.013)]. ROC curve analysis for 7 th day post-LT GFR was 0.71 (95% CI 0.61-0.81). Conclusion. The 7 th day post-LT GFR in cirrhotic patients may be a use - ful clinical tool to identify which patients might benefit from earlier nephroprotective immunosuppression. 2014 artículo científico 2469-1119 https://www.redalyc.org/articulo.oa?id=199333044010 en http://www.redalyc.org/revista.oa?id=1993 Acta Gastroenterológica Latinoamericana application/pdf Sociedad Argentina de Gastroenterología Acta Gastroenterológica Latinoamericana (Argentina) Num.4 Vol.44 |
| title | Early predictors of renal dysfunction in cirrhotic patients after liver transplantation |
| topic | Medicina Cirrhosis renal failure immunosuppression liver transplantation |
| url | https://www.redalyc.org/articulo.oa?id=199333044010 |