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| Format: | Artículo científico |
| Language: | en |
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Sociedad Argentina de Gastroenterología
2015
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| Online Access: | https://www.redalyc.org/articulo.oa?id=199336842017 |
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| _version_ | 1866812033502019584 |
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| author | Sebastián Marciano |
| author_facet | Sebastián Marciano |
| contents | Successful treatment with telaprevir of post-transplant fibrosing cholestatic hepatitis C in an HIV co-infected patient Sebastián Marciano Omar Andrés Galdame Laura Alicia Barcan Adrián Carlos Gadano Medicina graft loss protease inhibitors hepatitis C recurrence Direct antiviral agents Hepatitis C recurrence is the main cause of graft loss in liver transplant patients co-infected with human immunodeficiency virus (HIV). These patients have higher risk of fibrosing cholestatic hepatitis, which is the most severe type of hepatitis C recurrence. Until direct antiviral agents were released, only a minority of patients could be satisfactorily treated. We describe the successful treatment with pegylatedinterferon, ribavirin and telaprevir of an hepatitis C virus (HCV)/HIV co-infected patient who developed fibrosing cholestatic hepatitis after liver transplantation. A 40-yearold male (HCV genotype 1a; IL-28 CC) underwent liver transplantation for decompensated cirrhosis. On post-transplant day 60, he rapidly developed progressive jaundice, worsening of liver function tests and ascites. A transjugular liver biopsy confirmed the diagnosis of fibrosing cholestatic hepatitis. Treatment with pegylated-interferon, ribavirin and telaprevir was indicated for 48 weeks, achieving sustained virological response at 12 weeks of follow-up. The rapid negativization of the viral load observed during the first 4 weeks of treatment was associated with regression of ascites and jaundice. Red blood cell transfusions, erythropoietin and filgrastim were required for the management of anemia and neutropenia. Triple therapy with telaprevir might be indicated for the treatment of severe HCV recurrence in selected HCV/HIV co-infected patients, especially in countries with limited access to pegylated-interferon-free regimens. Key words. 2015 artículo científico 2469-1119 https://www.redalyc.org/articulo.oa?id=199336842017 en http://www.redalyc.org/revista.oa?id=1993 Acta Gastroenterológica Latinoamericana application/pdf Sociedad Argentina de Gastroenterología Acta Gastroenterológica Latinoamericana (Argentina) Num.1 Vol.45 |
| format | Artículo científico |
| id | redalyc_199336842017 |
| language | en |
| publishDate | 2015 |
| publisher | Sociedad Argentina de Gastroenterología |
| spellingShingle | Successful treatment with telaprevir of post-transplant fibrosing cholestatic hepatitis C in an HIV co-infected patient Sebastián Marciano Medicina graft loss protease inhibitors hepatitis C recurrence Direct antiviral agents Successful treatment with telaprevir of post-transplant fibrosing cholestatic hepatitis C in an HIV co-infected patient Sebastián Marciano Omar Andrés Galdame Laura Alicia Barcan Adrián Carlos Gadano Medicina graft loss protease inhibitors hepatitis C recurrence Direct antiviral agents Hepatitis C recurrence is the main cause of graft loss in liver transplant patients co-infected with human immunodeficiency virus (HIV). These patients have higher risk of fibrosing cholestatic hepatitis, which is the most severe type of hepatitis C recurrence. Until direct antiviral agents were released, only a minority of patients could be satisfactorily treated. We describe the successful treatment with pegylatedinterferon, ribavirin and telaprevir of an hepatitis C virus (HCV)/HIV co-infected patient who developed fibrosing cholestatic hepatitis after liver transplantation. A 40-yearold male (HCV genotype 1a; IL-28 CC) underwent liver transplantation for decompensated cirrhosis. On post-transplant day 60, he rapidly developed progressive jaundice, worsening of liver function tests and ascites. A transjugular liver biopsy confirmed the diagnosis of fibrosing cholestatic hepatitis. Treatment with pegylated-interferon, ribavirin and telaprevir was indicated for 48 weeks, achieving sustained virological response at 12 weeks of follow-up. The rapid negativization of the viral load observed during the first 4 weeks of treatment was associated with regression of ascites and jaundice. Red blood cell transfusions, erythropoietin and filgrastim were required for the management of anemia and neutropenia. Triple therapy with telaprevir might be indicated for the treatment of severe HCV recurrence in selected HCV/HIV co-infected patients, especially in countries with limited access to pegylated-interferon-free regimens. Key words. 2015 artículo científico 2469-1119 https://www.redalyc.org/articulo.oa?id=199336842017 en http://www.redalyc.org/revista.oa?id=1993 Acta Gastroenterológica Latinoamericana application/pdf Sociedad Argentina de Gastroenterología Acta Gastroenterológica Latinoamericana (Argentina) Num.1 Vol.45 |
| title | Successful treatment with telaprevir of post-transplant fibrosing cholestatic hepatitis C in an HIV co-infected patient |
| topic | Medicina graft loss protease inhibitors hepatitis C recurrence Direct antiviral agents |
| url | https://www.redalyc.org/articulo.oa?id=199336842017 |