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| Format: | Artículo científico |
| Language: | en |
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Sociedad Argentina de Gastroenterología
2017
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| Online Access: | https://www.redalyc.org/articulo.oa?id=199352918005 |
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Table of Contents:
- Increase of Helicobacter pylori infection and decrease in immunity in recent years Yulia A Belaya Olga F Belaya Vladimir G Petrukhin Svetlana M Bystrova Alexander V Pronin Maria S Vakhrameeva Medicina LPS VAC A CAG A immunity O antigens Some gastrointestinal disease are relationed with H pylori (Hp), a microorganism that is part of the gastric microbiota. It affects 50 to 90% of the world population. Objetive. Analyzed changes in the frequency of occurrence of LPS/O, VAC A antigens and high molecular weight proteins (HMWP, including CAG) of Hp and their specific immune complexes with IgG-class antibodies of inmunoglobulins (IgG-CIC) in patients with gastric diseases and volunteers in recent years. Material and methods. In the period of 2009-2016 samples of stools and circulating immune complexes (CIC) of serum samples of stools and circulating immune complexes (CIC) in 8568 patients with gastric diseases were evaluated and samples of stool, saliva and CIC of 23 volunteers were monitored and 14601 samples of biomaterials were studied. The reaction of coaglutination on glass and plates with specially prepared antibody diagnosis were used. LPS/O antigens of Hp werw detected in heated stool and saliva samples in reaction on glass; VAC A antigens and HMWP antigens in CIC composition of blood serum and saliva. Results. For the first time since year 2000, 27-55% increase (enhanced since 2009) the frequency of LPS/O antigens occurrence in the stool. It is a marker of Hp reproduction in the gastric mucosa. Additionally, more pronounced cyclical changes in the frequency of VAC A, CAG A detection, as well as a decrease in the frequency of virulence antigens was observed in the composition of CIC of blood serum and saliva, showing a 35-68% decrease in the body immune response. Conclusions. There is a increase in Hp infection due to decrease immunity to the Hp pathogenic factors, especially pronounced in 2012- the first half of 2016, indicating the possibility of increased risk of new diseases, exacerbations and adverse outcomes of Hp infection (peptic ulcer disease, atrophic gastritis, gastric cancer and gastric malt lymphoma). 2017 artículo científico 2469-1119 https://www.redalyc.org/articulo.oa?id=199352918005 en http://www.redalyc.org/revista.oa?id=1993 Acta Gastroenterológica Latinoamericana application/pdf Sociedad Argentina de Gastroenterología Acta Gastroenterológica Latinoamericana (Argentina) Num.3 Vol.47