Exocrine pancreas function - sex, age, estrogenic and cholinergic tone - preliminary clinical value of citrates “magic powder”
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| Format: | Artículo científico |
| Langue: | en |
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Sociedad Argentina de Gastroenterología
2019
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| _version_ | 1876451305989341184 |
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| author | Osvaldo Manuel Tiscornia |
| author_facet | Osvaldo Manuel Tiscornia |
| contents | Exocrine pancreas function - sex, age, estrogenic and cholinergic tone - preliminary clinical value of citrates “magic powder” Osvaldo Manuel Tiscornia Fabiana Norma López Mingorance Julieta Agustina Repetti Simmy Bank Patricia Graciela Tiscornia-Wasserman Medicina Secretin citrates menopause plexus reticular This study pivots on exocrine pancreatic secretion. We choose 45 years limit, distinguishing two stages characterized by an imbalance of sexual hormones in women and men. The secretin test was performed on 40 women and 47 men to evaluate the exocrine pancreatic function, taking age, as the central axis. In the group analyzed below the age of 45 there were no significant differences in the agreement with sex; but there were relevant differences between men and women above 45 years of age. The hormone secretin regulates the synthesis of lipase by interacting with the intrapancreatic cholinergic tone. When this is depresses, so does the debit of lipase. Pancreatic acini and islets have a high number of estrogen receptors, which activate and modulate the response of the gland to secretin, CCK and acetylcholine. Estrogen activates the beta cells stimulating the release of insulin, which enhances the ecbolic secretion induced by CCK. We conclude that during menopause the decrease in estradiol leads to less interaction with the secretin hormone receptors, which leads to a high percentage of dyspeptic syndrome, ultimately menopausal chronic pancreatopathy / menopausal pancreatic insufficiency. This is reversed with the administration of estradiol. In men older than 45 years we observed an increase in lipase secretion, a consequence of a hyperestrogenism caused by the aromatization of androgens. From clinical experience we observed the beneficial effect of citrate powder in patients with dyspeptic syndrome, gastritis and pancreatopathies, which demonstrate that they induce the release of secretin from the duodenal mucosa. 2019 artículo científico 2469-1119 https://www.redalyc.org/articulo.oa?id=199362054004 https://www.redalyc.org/journal/1993/199362054004/ https://www.redalyc.org/journal/1993/199362054004/html/ https://www.redalyc.org/journal/1993/199362054004/199362054004.epub https://www.redalyc.org/journal/1993/199362054004/movil en http://www.redalyc.org/revista.oa?id=1993 Acta Gastroenterológica Latinoamericana application/pdf Sociedad Argentina de Gastroenterología Acta Gastroenterológica Latinoamericana (Argentina) Num.4 Vol.49 |
| format | Artículo científico |
| id | redalyc_199362054004 |
| institution | Redalyc |
| language | en |
| publishDate | 2019 |
| publisher | Sociedad Argentina de Gastroenterología |
| spellingShingle | Exocrine pancreas function - sex, age, estrogenic and cholinergic tone - preliminary clinical value of citrates “magic powder” Osvaldo Manuel Tiscornia Medicina Secretin citrates menopause plexus reticular Exocrine pancreas function - sex, age, estrogenic and cholinergic tone - preliminary clinical value of citrates “magic powder” Osvaldo Manuel Tiscornia Fabiana Norma López Mingorance Julieta Agustina Repetti Simmy Bank Patricia Graciela Tiscornia-Wasserman Medicina Secretin citrates menopause plexus reticular This study pivots on exocrine pancreatic secretion. We choose 45 years limit, distinguishing two stages characterized by an imbalance of sexual hormones in women and men. The secretin test was performed on 40 women and 47 men to evaluate the exocrine pancreatic function, taking age, as the central axis. In the group analyzed below the age of 45 there were no significant differences in the agreement with sex; but there were relevant differences between men and women above 45 years of age. The hormone secretin regulates the synthesis of lipase by interacting with the intrapancreatic cholinergic tone. When this is depresses, so does the debit of lipase. Pancreatic acini and islets have a high number of estrogen receptors, which activate and modulate the response of the gland to secretin, CCK and acetylcholine. Estrogen activates the beta cells stimulating the release of insulin, which enhances the ecbolic secretion induced by CCK. We conclude that during menopause the decrease in estradiol leads to less interaction with the secretin hormone receptors, which leads to a high percentage of dyspeptic syndrome, ultimately menopausal chronic pancreatopathy / menopausal pancreatic insufficiency. This is reversed with the administration of estradiol. In men older than 45 years we observed an increase in lipase secretion, a consequence of a hyperestrogenism caused by the aromatization of androgens. From clinical experience we observed the beneficial effect of citrate powder in patients with dyspeptic syndrome, gastritis and pancreatopathies, which demonstrate that they induce the release of secretin from the duodenal mucosa. 2019 artículo científico 2469-1119 https://www.redalyc.org/articulo.oa?id=199362054004 https://www.redalyc.org/journal/1993/199362054004/ https://www.redalyc.org/journal/1993/199362054004/html/ https://www.redalyc.org/journal/1993/199362054004/199362054004.epub https://www.redalyc.org/journal/1993/199362054004/movil en http://www.redalyc.org/revista.oa?id=1993 Acta Gastroenterológica Latinoamericana application/pdf Sociedad Argentina de Gastroenterología Acta Gastroenterológica Latinoamericana (Argentina) Num.4 Vol.49 |
| title | Exocrine pancreas function - sex, age, estrogenic and cholinergic tone - preliminary clinical value of citrates “magic powder” |
| topic | Medicina Secretin citrates menopause plexus reticular |
| url | https://www.redalyc.org/articulo.oa?id=199362054004 https://www.redalyc.org/journal/1993/199362054004/ https://www.redalyc.org/journal/1993/199362054004/html/ https://www.redalyc.org/journal/1993/199362054004/199362054004.epub https://www.redalyc.org/journal/1993/199362054004/movil |