Development and characterization of murine monoclonal antibody specific for the P1.4 PorA proteins from strain B:4:P1.(7b).4. of Neisseria meningitidis
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| Natura: | Artículo científico |
| Lingua: | en |
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Instituto Finlay
2011
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| _version_ | 1876487174935805952 |
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| author | María Elena Pérez |
| author_facet | María Elena Pérez |
| contents | Development and characterization of murine monoclonal antibody specific for the P1.4 PorA proteins from strain B:4:P1.(7b).4. of Neisseria meningitidis María Elena Pérez Ramón Barberá Francisco Domínguez Oscar Otero Mercedes Gutiérrez Gustavo Falero Grethel Reyes Franklin Sotolongo Gustavo Sierra Salud PorA Monoclonal Antibodies Neisseria meningitidis Neisseria meningitidis isolates are conventionally classified by serosubtyping that characterizes the reactivities of the PorA outer membrane protein variable-region epitopes with monoclonal antibodies. Porins are outer membrane proteins (OMPs) of N. meningitidis serogroup B and have attracted study principally for two reasons: their use in the classification of meningococcal isolates into serotype and subtype and as potential components of vaccines against this important pathogen. New murine hybridomas, secreting specific monoclonal antibodies against PorA serotype P1.4 of N. meningitidis serogroup B, were generated using conventional hybridoma procedures. The monoclonal antibodies obtained were characterized by Western blot and whole cell ELISA, using reference strains from different N. meningitidis serotypes and subtypes. All monoclonal antibodies belong to isotype IgG1. Others hybridomas producing MAbs against PorB and FrpB were also obtained. 2011 artículo científico 1025-0298 https://www.redalyc.org/articulo.oa?id=203419367002 en http://www.redalyc.org/revista.oa?id=2034 VacciMonitor application/pdf Instituto Finlay VacciMonitor (Cuba) Num.2 Vol.20 |
| format | Artículo científico |
| id | redalyc_203419367002 |
| institution | Redalyc |
| language | en |
| publishDate | 2011 |
| publisher | Instituto Finlay |
| spellingShingle | Development and characterization of murine monoclonal antibody specific for the P1.4 PorA proteins from strain B:4:P1.(7b).4. of Neisseria meningitidis María Elena Pérez Salud PorA Monoclonal Antibodies Neisseria meningitidis Development and characterization of murine monoclonal antibody specific for the P1.4 PorA proteins from strain B:4:P1.(7b).4. of Neisseria meningitidis María Elena Pérez Ramón Barberá Francisco Domínguez Oscar Otero Mercedes Gutiérrez Gustavo Falero Grethel Reyes Franklin Sotolongo Gustavo Sierra Salud PorA Monoclonal Antibodies Neisseria meningitidis Neisseria meningitidis isolates are conventionally classified by serosubtyping that characterizes the reactivities of the PorA outer membrane protein variable-region epitopes with monoclonal antibodies. Porins are outer membrane proteins (OMPs) of N. meningitidis serogroup B and have attracted study principally for two reasons: their use in the classification of meningococcal isolates into serotype and subtype and as potential components of vaccines against this important pathogen. New murine hybridomas, secreting specific monoclonal antibodies against PorA serotype P1.4 of N. meningitidis serogroup B, were generated using conventional hybridoma procedures. The monoclonal antibodies obtained were characterized by Western blot and whole cell ELISA, using reference strains from different N. meningitidis serotypes and subtypes. All monoclonal antibodies belong to isotype IgG1. Others hybridomas producing MAbs against PorB and FrpB were also obtained. 2011 artículo científico 1025-0298 https://www.redalyc.org/articulo.oa?id=203419367002 en http://www.redalyc.org/revista.oa?id=2034 VacciMonitor application/pdf Instituto Finlay VacciMonitor (Cuba) Num.2 Vol.20 |
| title | Development and characterization of murine monoclonal antibody specific for the P1.4 PorA proteins from strain B:4:P1.(7b).4. of Neisseria meningitidis |
| topic | Salud PorA Monoclonal Antibodies Neisseria meningitidis |
| url | https://www.redalyc.org/articulo.oa?id=203419367002 |