Effect of physical therapy on joint range of motion and muscle collagen deposition in the golden retriever muscular dystrophy (GRMD) model
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| Format: | Artículo científico |
| Langue: | en |
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Associação Brasileira de Pesquisa e Pós-Graduação em Fisioterapia
2009
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| _version_ | 1876428815512633344 |
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| author | TP Gaiad |
| author_facet | TP Gaiad |
| contents | Effect of physical therapy on joint range of motion and muscle collagen deposition in the golden retriever muscular dystrophy (GRMD) model TP Gaiad MA Miglino M Zatz WC Hamlett CE Ambrosio Salud joints collagen animal model physical therapy muscular dystrophy OBJECTIVE: To elucidate the effect of physical therapy on joint range of motion (ROM) and muscle fibrosis in GRMD animals. METHODS: This was a nonrandomized blinded study with a control group, with six months of intervention evaluated beforehand and afterwards. Six dystrophic male Golden Retrievers of mean age 10.16±3.46 months and weight 17.75±6.01 kg were divided into a treated group (n=3) and an untreated group. These groups of dogs were named: G1=treated group before treatment; G2=treated group after treatment; G3=untreated group before treatment; and G4=untreated group after treatment. G1 underwent a physical therapy program that consisted of a 300-meter circuit with obstacles. Stifle, tarsal, elbow and carpal ROM were assessed using a goniometer before and after treatment. The area of collagen in the vastus lateralis muscle was measured using histomorphometry. The locations of collagen types I, III and IV were studied using immunohistochemistry. RESULTS: The tarsal ROM values in G2 presented an increasing trend. The area of muscle collagen differed between the groups after treatment and an increasing trend in these values was observed in G4. Collagen types I and III were the ones most frequently observed, forming broad bands in the perimysium of both G2 and G4. Type I collagen was observed in the endomysium more than type III collagen. Type IV collagen was observed only in the basal layer. CONCLUSION: Physical Therapy seemed to improve tarsal ROM in the treated group without increasing muscular fibrosis. 2009 artículo científico 1413-3555 https://www.redalyc.org/articulo.oa?id=235016469009 en http://www.redalyc.org/revista.oa?id=2350 Revista Brasileira de Fisioterapia application/pdf Associação Brasileira de Pesquisa e Pós-Graduação em Fisioterapia Revista Brasileira de Fisioterapia (Brasil) Num.3 Vol.13 |
| format | Artículo científico |
| id | redalyc_235016469009 |
| institution | Redalyc |
| language | en |
| publishDate | 2009 |
| publisher | Associação Brasileira de Pesquisa e Pós-Graduação em Fisioterapia |
| spellingShingle | Effect of physical therapy on joint range of motion and muscle collagen deposition in the golden retriever muscular dystrophy (GRMD) model TP Gaiad Salud joints collagen animal model physical therapy muscular dystrophy Effect of physical therapy on joint range of motion and muscle collagen deposition in the golden retriever muscular dystrophy (GRMD) model TP Gaiad MA Miglino M Zatz WC Hamlett CE Ambrosio Salud joints collagen animal model physical therapy muscular dystrophy OBJECTIVE: To elucidate the effect of physical therapy on joint range of motion (ROM) and muscle fibrosis in GRMD animals. METHODS: This was a nonrandomized blinded study with a control group, with six months of intervention evaluated beforehand and afterwards. Six dystrophic male Golden Retrievers of mean age 10.16±3.46 months and weight 17.75±6.01 kg were divided into a treated group (n=3) and an untreated group. These groups of dogs were named: G1=treated group before treatment; G2=treated group after treatment; G3=untreated group before treatment; and G4=untreated group after treatment. G1 underwent a physical therapy program that consisted of a 300-meter circuit with obstacles. Stifle, tarsal, elbow and carpal ROM were assessed using a goniometer before and after treatment. The area of collagen in the vastus lateralis muscle was measured using histomorphometry. The locations of collagen types I, III and IV were studied using immunohistochemistry. RESULTS: The tarsal ROM values in G2 presented an increasing trend. The area of muscle collagen differed between the groups after treatment and an increasing trend in these values was observed in G4. Collagen types I and III were the ones most frequently observed, forming broad bands in the perimysium of both G2 and G4. Type I collagen was observed in the endomysium more than type III collagen. Type IV collagen was observed only in the basal layer. CONCLUSION: Physical Therapy seemed to improve tarsal ROM in the treated group without increasing muscular fibrosis. 2009 artículo científico 1413-3555 https://www.redalyc.org/articulo.oa?id=235016469009 en http://www.redalyc.org/revista.oa?id=2350 Revista Brasileira de Fisioterapia application/pdf Associação Brasileira de Pesquisa e Pós-Graduação em Fisioterapia Revista Brasileira de Fisioterapia (Brasil) Num.3 Vol.13 |
| title | Effect of physical therapy on joint range of motion and muscle collagen deposition in the golden retriever muscular dystrophy (GRMD) model |
| topic | Salud joints collagen animal model physical therapy muscular dystrophy |
| url | https://www.redalyc.org/articulo.oa?id=235016469009 |