Inhibition of nitric oxide synthesis for four days induces vascular abnormalities and myocardial infarct areas but not significant arterial hypertension
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| Format: | Artículo científico |
| Language: | en |
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Sociedade Brasileira de Angiologia e de Cirurgia Vascular
2012
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| author | Ricardo Xavier-Vidal |
| author_facet | Ricardo Xavier-Vidal |
| contents | Inhibition of nitric oxide synthesis for four days induces vascular abnormalities and myocardial infarct areas but not significant arterial hypertension Ricardo Xavier-Vidal Medicina NAME heart cardiopathy Nitric oxide hypertension Background: Nitric oxide is an endothelium vasorelaxing factor and at least in some cases is the main cause of arterial hypertension, which is one of the most important risk factors of cardiovascular diseases. In Brazil, cardiovascular diseases are the first cause of mortality, representing about 30% of the total deaths. The L-NAME (N¿-nitro-arginine-methyl-ester) blocks the nitric oxide synthesis necessary to maintain the normal arterial pressure. Objective: To study lesions in myocardium due to the inhibition of nitric oxide synthesis during four days (via L-NAME oral administration, concentration: 75 mgs versus 100 mL-1). Methods: Fourteen normotensive young adults Wistar rats were submitted, during four days, to L-NAME. Six rats were utilized as the Control Group. At day 4 of the experiment, the animals were anesthetized, weighed, and their thoraxes were opened, and the cardiotomy was performed. The hearts were weighed, fixed, and processed using routine methods, and they were sectioned in 3 ¿m and stained. Results: Abnormalities were observed in the wall of arterial vessels of any dimension, as vascular damage with increasing wall thickness related mainly to proliferation of arterial smooth muscle cell in submitted animals. Proliferation of cells in the intimal layer and its thickening were also observed in small arterial vessels (arteriole). Infarct areas were present.Conclusions: The present data suggested that inhibition of nitric oxide synthesis for four days induces vascular abnormalities and myocardial infarct areas, but not arterial hypertension. 2012 artículo científico 1677-5449 https://www.redalyc.org/articulo.oa?id=245023716010 en http://www.redalyc.org/revista.oa?id=2450 Jornal Vascular Brasileiro application/pdf Sociedade Brasileira de Angiologia e de Cirurgia Vascular Jornal Vascular Brasileiro (Brasil) Num.2 Vol.11 |
| format | Artículo científico |
| id | redalyc_245023716010 |
| institution | Redalyc |
| language | en |
| publishDate | 2012 |
| publisher | Sociedade Brasileira de Angiologia e de Cirurgia Vascular |
| spellingShingle | Inhibition of nitric oxide synthesis for four days induces vascular abnormalities and myocardial infarct areas but not significant arterial hypertension Ricardo Xavier-Vidal Medicina NAME heart cardiopathy Nitric oxide hypertension Inhibition of nitric oxide synthesis for four days induces vascular abnormalities and myocardial infarct areas but not significant arterial hypertension Ricardo Xavier-Vidal Medicina NAME heart cardiopathy Nitric oxide hypertension Background: Nitric oxide is an endothelium vasorelaxing factor and at least in some cases is the main cause of arterial hypertension, which is one of the most important risk factors of cardiovascular diseases. In Brazil, cardiovascular diseases are the first cause of mortality, representing about 30% of the total deaths. The L-NAME (N¿-nitro-arginine-methyl-ester) blocks the nitric oxide synthesis necessary to maintain the normal arterial pressure. Objective: To study lesions in myocardium due to the inhibition of nitric oxide synthesis during four days (via L-NAME oral administration, concentration: 75 mgs versus 100 mL-1). Methods: Fourteen normotensive young adults Wistar rats were submitted, during four days, to L-NAME. Six rats were utilized as the Control Group. At day 4 of the experiment, the animals were anesthetized, weighed, and their thoraxes were opened, and the cardiotomy was performed. The hearts were weighed, fixed, and processed using routine methods, and they were sectioned in 3 ¿m and stained. Results: Abnormalities were observed in the wall of arterial vessels of any dimension, as vascular damage with increasing wall thickness related mainly to proliferation of arterial smooth muscle cell in submitted animals. Proliferation of cells in the intimal layer and its thickening were also observed in small arterial vessels (arteriole). Infarct areas were present.Conclusions: The present data suggested that inhibition of nitric oxide synthesis for four days induces vascular abnormalities and myocardial infarct areas, but not arterial hypertension. 2012 artículo científico 1677-5449 https://www.redalyc.org/articulo.oa?id=245023716010 en http://www.redalyc.org/revista.oa?id=2450 Jornal Vascular Brasileiro application/pdf Sociedade Brasileira de Angiologia e de Cirurgia Vascular Jornal Vascular Brasileiro (Brasil) Num.2 Vol.11 |
| title | Inhibition of nitric oxide synthesis for four days induces vascular abnormalities and myocardial infarct areas but not significant arterial hypertension |
| topic | Medicina NAME heart cardiopathy Nitric oxide hypertension |
| url | https://www.redalyc.org/articulo.oa?id=245023716010 |