17-hydroxyprogesterone levels in blood from the heels of healthy full-term newborns
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| Natura: | Artículo científico |
| Lingua: | en |
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Universidad CES
2017
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| _version_ | 1876431422408884224 |
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| author | Victor Manuel Mora-Bautista |
| author_facet | Victor Manuel Mora-Bautista |
| contents | 17-hydroxyprogesterone levels in blood from the heels of healthy full-term newborns Victor Manuel Mora-Bautista Jhon Freddy Martínez-Paredes Alba Luz Calderón-Rojas Carlos Augusto Gómez-Tarazona Katherine Pinzón-Mantilla Gerardo Mantilla-Mora Luis Alfonso Díaz-Martínez Gustavo Adolfo Contreras-García Victor Clemente Mendoza-Rojas Medicina 17 Screening Newborn infant Gestational age hydroxyprogesterone Background and aim : Congenital adrenal hyperplasia is caused by enzymatic abnormalities in the synthesis of adrenal steroids. A pilot study was carried out to measure the values of 17- hydroxyprogesterone (17- OHP) in a sample of healthy full-term newborns; the present study aims to determine if birth weight or gender have differences on 17-OHP. Design: Transversal, descriptive, and prolective study. Methods: We included 81 healthy full-term newborns with normal prenatal controls born between July 18th, 2014, and August 1st, 2015. We took whole blood using the heel prick test when the babies were three to five days old. Socioeconomic and clinical data were collected. Non-extracted 17-OHP ELISA was used. Its cut-off point was 20 ng/mL. If results were above cut-off point, babies were recalled for a new measure since transient high 17-hydroxyprogesterone levels are possible until babies are three months of age. Results : Gestatio - nal age varied between 37.0 to 41.5 weeks. Non-extracted 17-OHP levels ranged between 2.6 to 29.5 ng/mL (median: 11.5, IQR 7.2 to 15.1). 17-OHP levels variation per birth weight or gender were not found. Conclusions : In full therm newborns is expected a lesser variation that may explain these results. Quality issues should be solved before starting a screening program in our population because socioeconomic issues cause most problems in recalling positive screening babies. 2017 artículo científico 0120-8705 https://www.redalyc.org/articulo.oa?id=261152682002 en http://www.redalyc.org/revista.oa?id=2611 CES Medicina application/pdf Universidad CES CES Medicina (Colombia) Num.2 Vol.31 |
| format | Artículo científico |
| id | redalyc_261152682002 |
| institution | Redalyc |
| language | en |
| publishDate | 2017 |
| publisher | Universidad CES |
| spellingShingle | 17-hydroxyprogesterone levels in blood from the heels of healthy full-term newborns Victor Manuel Mora-Bautista Medicina 17 Screening Newborn infant Gestational age hydroxyprogesterone 17-hydroxyprogesterone levels in blood from the heels of healthy full-term newborns Victor Manuel Mora-Bautista Jhon Freddy Martínez-Paredes Alba Luz Calderón-Rojas Carlos Augusto Gómez-Tarazona Katherine Pinzón-Mantilla Gerardo Mantilla-Mora Luis Alfonso Díaz-Martínez Gustavo Adolfo Contreras-García Victor Clemente Mendoza-Rojas Medicina 17 Screening Newborn infant Gestational age hydroxyprogesterone Background and aim : Congenital adrenal hyperplasia is caused by enzymatic abnormalities in the synthesis of adrenal steroids. A pilot study was carried out to measure the values of 17- hydroxyprogesterone (17- OHP) in a sample of healthy full-term newborns; the present study aims to determine if birth weight or gender have differences on 17-OHP. Design: Transversal, descriptive, and prolective study. Methods: We included 81 healthy full-term newborns with normal prenatal controls born between July 18th, 2014, and August 1st, 2015. We took whole blood using the heel prick test when the babies were three to five days old. Socioeconomic and clinical data were collected. Non-extracted 17-OHP ELISA was used. Its cut-off point was 20 ng/mL. If results were above cut-off point, babies were recalled for a new measure since transient high 17-hydroxyprogesterone levels are possible until babies are three months of age. Results : Gestatio - nal age varied between 37.0 to 41.5 weeks. Non-extracted 17-OHP levels ranged between 2.6 to 29.5 ng/mL (median: 11.5, IQR 7.2 to 15.1). 17-OHP levels variation per birth weight or gender were not found. Conclusions : In full therm newborns is expected a lesser variation that may explain these results. Quality issues should be solved before starting a screening program in our population because socioeconomic issues cause most problems in recalling positive screening babies. 2017 artículo científico 0120-8705 https://www.redalyc.org/articulo.oa?id=261152682002 en http://www.redalyc.org/revista.oa?id=2611 CES Medicina application/pdf Universidad CES CES Medicina (Colombia) Num.2 Vol.31 |
| title | 17-hydroxyprogesterone levels in blood from the heels of healthy full-term newborns |
| topic | Medicina 17 Screening Newborn infant Gestational age hydroxyprogesterone |
| url | https://www.redalyc.org/articulo.oa?id=261152682002 |