Determination of the prevalence of hemoglobin S, C, D, and G in neonates from Buenaventura, Colombia
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| Natura: | Artículo científico |
| Lingua: | en |
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Universidad del Valle
2010
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| _version_ | 1876442931904118784 |
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| author | Matilde de Bernal |
| author_facet | Matilde de Bernal |
| contents | Determination of the prevalence of hemoglobin S, C, D, and G in neonates from Buenaventura, Colombia Matilde de Bernal Andrés Collazos Rubén Darío Bonilla Edna Patricia Tascón Medicina Anemia Newborn Colombia Prevalence Sickle cell Introduction: Inherited hemoglobinopathies are common among African Blacks. In Buenaventura, a city on Colombias Pacific coast, where 92% of the population is Afro-Colombian, there are few published attempts to identify these disorders. Affected individuals require more health care due to higher morbidity and mortality. Early identification of these newborns followed by comprehensive care is important to reduce co-morbidities. Objective: To study newborns and establish the numbers at risk with a bloodspot screening method. This information will demonstrate to Public Health Authorities the need to provide care for this population. Methods: A cross-sectional descriptive study of a sample of 399 newborns (95% CI) where there is an expected prevalence of 10% of abnormal hemoglobins. Mothers in at least the 36th week of gestation, living in the urban area of Buenaventura, were used. Umbilical cord blood was drawn and specimens fixed on filter paper and stored at 4°C. Isoelectric focusing electrophoresis assays were used to separate the hemoglobins. The results were reported according to the identified hemoglobin as F, A, S, C, D, and G. Results: We processed 399 samples, 353 (88.5%) were normal (hemoglobin FA), 23 (5.8%) were heterozygous for hemoglobin C (FAC), 19 (4.8%) were heterozygous for hemoglobin S (FAS), 2 (0.5%) were heterozygous for hemoglobin G (FAG), 1 was heterozygous for hemoglobin D (FAD) and 1 was heterozygous combined S and C (FSC). Conclusion: Hemoglobins S, C, D, and G are common among infants born in Buenaventura. Hemoglobin C occurred more frequently than in other reported studies. This study suggests that both detection and a follow-up program are required in areas with a high density of Afro-Colombian population 2010 artículo científico 0120-8322 https://www.redalyc.org/articulo.oa?id=28316817005 en http://www.redalyc.org/revista.oa?id=283 Colombia Médica application/pdf Universidad del Valle Colombia Médica (Colombia) Num.2 Vol.41 |
| format | Artículo científico |
| id | redalyc_28316817005 |
| institution | Redalyc |
| language | en |
| publishDate | 2010 |
| publisher | Universidad del Valle |
| spellingShingle | Determination of the prevalence of hemoglobin S, C, D, and G in neonates from Buenaventura, Colombia Matilde de Bernal Medicina Anemia Newborn Colombia Prevalence Sickle cell Determination of the prevalence of hemoglobin S, C, D, and G in neonates from Buenaventura, Colombia Matilde de Bernal Andrés Collazos Rubén Darío Bonilla Edna Patricia Tascón Medicina Anemia Newborn Colombia Prevalence Sickle cell Introduction: Inherited hemoglobinopathies are common among African Blacks. In Buenaventura, a city on Colombias Pacific coast, where 92% of the population is Afro-Colombian, there are few published attempts to identify these disorders. Affected individuals require more health care due to higher morbidity and mortality. Early identification of these newborns followed by comprehensive care is important to reduce co-morbidities. Objective: To study newborns and establish the numbers at risk with a bloodspot screening method. This information will demonstrate to Public Health Authorities the need to provide care for this population. Methods: A cross-sectional descriptive study of a sample of 399 newborns (95% CI) where there is an expected prevalence of 10% of abnormal hemoglobins. Mothers in at least the 36th week of gestation, living in the urban area of Buenaventura, were used. Umbilical cord blood was drawn and specimens fixed on filter paper and stored at 4°C. Isoelectric focusing electrophoresis assays were used to separate the hemoglobins. The results were reported according to the identified hemoglobin as F, A, S, C, D, and G. Results: We processed 399 samples, 353 (88.5%) were normal (hemoglobin FA), 23 (5.8%) were heterozygous for hemoglobin C (FAC), 19 (4.8%) were heterozygous for hemoglobin S (FAS), 2 (0.5%) were heterozygous for hemoglobin G (FAG), 1 was heterozygous for hemoglobin D (FAD) and 1 was heterozygous combined S and C (FSC). Conclusion: Hemoglobins S, C, D, and G are common among infants born in Buenaventura. Hemoglobin C occurred more frequently than in other reported studies. This study suggests that both detection and a follow-up program are required in areas with a high density of Afro-Colombian population 2010 artículo científico 0120-8322 https://www.redalyc.org/articulo.oa?id=28316817005 en http://www.redalyc.org/revista.oa?id=283 Colombia Médica application/pdf Universidad del Valle Colombia Médica (Colombia) Num.2 Vol.41 |
| title | Determination of the prevalence of hemoglobin S, C, D, and G in neonates from Buenaventura, Colombia |
| topic | Medicina Anemia Newborn Colombia Prevalence Sickle cell |
| url | https://www.redalyc.org/articulo.oa?id=28316817005 |