Nasal and vaginal colonization of methicillin-resistant Staphylococcus aureus in pregnant women in Cartagena, Colombia
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| Format: | Artículo científico |
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Universidad del Valle
2012
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| _version_ | 1876450007309090816 |
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| author | Oscar Correa |
| author_facet | Oscar Correa |
| contents | Nasal and vaginal colonization of methicillin-resistant Staphylococcus aureus in pregnant women in Cartagena, Colombia Oscar Correa Kelly Delgado Carla Rangel Ana Bello Niradiz Reyes Medicina Pregnancy resistance Methicillin Virulence factor Staphylococcus aureus Introduction: The host niche for Staphylococcus aureus (SA) are the anterior nares; however, vaginal colonizationrates between 14% and 17.1% in pregnant women have been recently reported, raising interest about the potentialrisk in postpartum women and in neonates from colonized mothers. Objectives: To determine the prevalence of nasal and vaginal colonization of SA and the antibiotic susceptibilityof the isolates in pregnant women attending a maternity hospital in Cartagena, Colombia. Methods: Nasal and vaginal swabs were obtained from participants and subjected to microbiological andmolecular assays. A post discharge follow-up was performed for up to four weeks. Results: From 100 pregnant women enrolled in the study, 34 were colonized with SA; 29 only in the nares, threeonly in the vagina, and two at both sites. Colonization of pregnant women with SA was more common in the naresthan in the vagina or at both sites [29/34 (85.3%) vs 3/34 (8.8%) and 2/34 (5.9%); p<0.05]. We obtained 36 SA isolates, nine (25%) of which were methicillin-resistant Staphylococcus aureus (MRSA), one was from the vagina; thus, the overall MRSA colonization rate among pregnant women was 9%. Molecular analysis showed thatPanton-Valentine leukocidin (PVL) genes were carried by the vaginal MRSA, seven of the nasal MRSA, and two ofthe Methicillinsensitive Staphy lococcus aureus (MSSA) isolates. Two MRSA isolates carried SCCmec type I and seven carried SCCmec type IV. Conclusions: Nasal colonization rate for SA in the study population was similar to previous reports. However, the frequency of nasal colonization of MRSA was higher while vaginal colonization of SA was lower than previously reported in other studies for similar populations. The MRSA isolates obtained showed a community profile. 2012 artículo científico 0120-8322 https://www.redalyc.org/articulo.oa?id=28323202003 en http://www.redalyc.org/revista.oa?id=283 Colombia Médica application/pdf Universidad del Valle Colombia Médica (Colombia) Num.1 Vol.43 |
| format | Artículo científico |
| id | redalyc_28323202003 |
| institution | Redalyc |
| language | en |
| publishDate | 2012 |
| publisher | Universidad del Valle |
| spellingShingle | Nasal and vaginal colonization of methicillin-resistant Staphylococcus aureus in pregnant women in Cartagena, Colombia Oscar Correa Medicina Pregnancy resistance Methicillin Virulence factor Staphylococcus aureus Nasal and vaginal colonization of methicillin-resistant Staphylococcus aureus in pregnant women in Cartagena, Colombia Oscar Correa Kelly Delgado Carla Rangel Ana Bello Niradiz Reyes Medicina Pregnancy resistance Methicillin Virulence factor Staphylococcus aureus Introduction: The host niche for Staphylococcus aureus (SA) are the anterior nares; however, vaginal colonizationrates between 14% and 17.1% in pregnant women have been recently reported, raising interest about the potentialrisk in postpartum women and in neonates from colonized mothers. Objectives: To determine the prevalence of nasal and vaginal colonization of SA and the antibiotic susceptibilityof the isolates in pregnant women attending a maternity hospital in Cartagena, Colombia. Methods: Nasal and vaginal swabs were obtained from participants and subjected to microbiological andmolecular assays. A post discharge follow-up was performed for up to four weeks. Results: From 100 pregnant women enrolled in the study, 34 were colonized with SA; 29 only in the nares, threeonly in the vagina, and two at both sites. Colonization of pregnant women with SA was more common in the naresthan in the vagina or at both sites [29/34 (85.3%) vs 3/34 (8.8%) and 2/34 (5.9%); p<0.05]. We obtained 36 SA isolates, nine (25%) of which were methicillin-resistant Staphylococcus aureus (MRSA), one was from the vagina; thus, the overall MRSA colonization rate among pregnant women was 9%. Molecular analysis showed thatPanton-Valentine leukocidin (PVL) genes were carried by the vaginal MRSA, seven of the nasal MRSA, and two ofthe Methicillinsensitive Staphy lococcus aureus (MSSA) isolates. Two MRSA isolates carried SCCmec type I and seven carried SCCmec type IV. Conclusions: Nasal colonization rate for SA in the study population was similar to previous reports. However, the frequency of nasal colonization of MRSA was higher while vaginal colonization of SA was lower than previously reported in other studies for similar populations. The MRSA isolates obtained showed a community profile. 2012 artículo científico 0120-8322 https://www.redalyc.org/articulo.oa?id=28323202003 en http://www.redalyc.org/revista.oa?id=283 Colombia Médica application/pdf Universidad del Valle Colombia Médica (Colombia) Num.1 Vol.43 |
| title | Nasal and vaginal colonization of methicillin-resistant Staphylococcus aureus in pregnant women in Cartagena, Colombia |
| topic | Medicina Pregnancy resistance Methicillin Virulence factor Staphylococcus aureus |
| url | https://www.redalyc.org/articulo.oa?id=28323202003 |