Salivary cortisol levels as a predictor of preeclampsia in adolescents
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| Format: | Artículo científico |
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Universidad del Valle
2012
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| author | Jaime Salvador-Moysén |
| author_facet | Jaime Salvador-Moysén |
| contents | Salivary cortisol levels as a predictor of preeclampsia in adolescents Jaime Salvador-Moysén José M. Ramírez-Aranda Yolanda Martínez-López Marisela Aguilar-Durán Medicina Pre Eclampsia Salivary cortisol Physiological Stress Pregnancy in Adolescence Objective: To determine the usefulness of salivary cortisol as a predictor of preeclampsia in adolescents. Methods: We carried out a nested case- control study. Somatometric, clinical, and biochemicaldata were obtained from 100 healthy pregnant adolescents and salivary cortisol was measured at 8:00, 12:00, and 20:00 hours on twooccasions during pregnancy, before 20 weeks, and after 30 weeks of gestation. The cortisol values between the group of healthy pregnant women and the group that developed preeclampsia were compared by using the Student¿s t, Mann-Whitney, and Wilcoxon tests. Also, the ROC curve of cortisol values and the Positive and Negative Predictive values of cortisol were estimated. Results: Values >14.9 nmol/L of cortisol were observed in the group that developed preeclampsia, providing a positive predictive value of 1 (100%). Values <10.1 nmol/L were observed in the control group,the negative predictive value was 1 (100%). The cutoff point of the ROC curve -before 20 weeks of gestation- in the members of the cohort was 13.9 nmol/L. Conclusions: The salivary cortisol values observed in the two evaluations made to each of thegroups showed statistically significant differences between the groups at 8 and 12 hours of the day. The values obtained enable establishing gradients that allow separating the group of healthy women that got ill with preeclampsia from the group that did not develop the illness before week 20. After week 30, the cortisol gradients are established more clearly in the group with preeclampsia and in the control group. The validation of these findings in larger samples would allowimplementing this procedure as a screening test for preeclampsia in groups of pregnant adolescents. 2012 artículo científico 0120-8322 https://www.redalyc.org/articulo.oa?id=28323202006 en http://www.redalyc.org/revista.oa?id=283 Colombia Médica application/pdf Universidad del Valle Colombia Médica (Colombia) Num.1 Vol.43 |
| format | Artículo científico |
| id | redalyc_28323202006 |
| institution | Redalyc |
| language | en |
| publishDate | 2012 |
| publisher | Universidad del Valle |
| spellingShingle | Salivary cortisol levels as a predictor of preeclampsia in adolescents Jaime Salvador-Moysén Medicina Pre Eclampsia Salivary cortisol Physiological Stress Pregnancy in Adolescence Salivary cortisol levels as a predictor of preeclampsia in adolescents Jaime Salvador-Moysén José M. Ramírez-Aranda Yolanda Martínez-López Marisela Aguilar-Durán Medicina Pre Eclampsia Salivary cortisol Physiological Stress Pregnancy in Adolescence Objective: To determine the usefulness of salivary cortisol as a predictor of preeclampsia in adolescents. Methods: We carried out a nested case- control study. Somatometric, clinical, and biochemicaldata were obtained from 100 healthy pregnant adolescents and salivary cortisol was measured at 8:00, 12:00, and 20:00 hours on twooccasions during pregnancy, before 20 weeks, and after 30 weeks of gestation. The cortisol values between the group of healthy pregnant women and the group that developed preeclampsia were compared by using the Student¿s t, Mann-Whitney, and Wilcoxon tests. Also, the ROC curve of cortisol values and the Positive and Negative Predictive values of cortisol were estimated. Results: Values >14.9 nmol/L of cortisol were observed in the group that developed preeclampsia, providing a positive predictive value of 1 (100%). Values <10.1 nmol/L were observed in the control group,the negative predictive value was 1 (100%). The cutoff point of the ROC curve -before 20 weeks of gestation- in the members of the cohort was 13.9 nmol/L. Conclusions: The salivary cortisol values observed in the two evaluations made to each of thegroups showed statistically significant differences between the groups at 8 and 12 hours of the day. The values obtained enable establishing gradients that allow separating the group of healthy women that got ill with preeclampsia from the group that did not develop the illness before week 20. After week 30, the cortisol gradients are established more clearly in the group with preeclampsia and in the control group. The validation of these findings in larger samples would allowimplementing this procedure as a screening test for preeclampsia in groups of pregnant adolescents. 2012 artículo científico 0120-8322 https://www.redalyc.org/articulo.oa?id=28323202006 en http://www.redalyc.org/revista.oa?id=283 Colombia Médica application/pdf Universidad del Valle Colombia Médica (Colombia) Num.1 Vol.43 |
| title | Salivary cortisol levels as a predictor of preeclampsia in adolescents |
| topic | Medicina Pre Eclampsia Salivary cortisol Physiological Stress Pregnancy in Adolescence |
| url | https://www.redalyc.org/articulo.oa?id=28323202006 |