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| Format: | Artículo científico |
| Sprache: | en |
| Veröffentlicht: |
Universidad del Valle
2012
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| Online-Zugang: | https://www.redalyc.org/articulo.oa?id=28323202011 |
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Inhaltsangabe:
- Molecular half-full mechanisms by phagocityc cells on invasive Aspergilosis Karla Rossanet Dzul-Rosado Viridiana Martínez-Campos Gaspar Peniche-Lara Jorge E. Zavala-Castro Medicina DC Toll SIGN Dectin Aspergillus Fungus from the Aspergillus genus mainly affects lung tissue, occurring when the integrity of the host immune system is compromised. The human body uses immunocompetence conditions from mechanical and enzymatic defenses and the action of the innate immune system cells and also uses adaptive responses to control infection. Neutrophils, macrophages, and dendritic cells are critical as antifungal effector cells possess surface receptors thatrecognize fungal structures and trigger specific responses. TLRs and Dectin-1 the most studied for this interaction. TLRs are responsible for the production and release of cytokines and Dectin-1 is essential in the phagocytosis of theparticle recognition and production of ROS. The best-studied cytokines and its crucial role in the response toAspergillus spp. are TNF-a, IFN-a, and IL-12. In this work, we reviewed the main mechanismsrelated to molecular receptors on phagocytic cells involved in the recognition of Aspergillus spp. Understanding the immune response in situations of immuno competence and its comparison in immunodeficient organisms could providealternatives to control invasive aspergillosis. 2012 artículo científico 0120-8322 https://www.redalyc.org/articulo.oa?id=28323202011 en http://www.redalyc.org/revista.oa?id=283 Colombia Médica application/pdf Universidad del Valle Colombia Médica (Colombia) Num.1 Vol.43