Identification of messenger RNA of fetoplacental source in maternal plasma of women with normal pregnancies and pregnancies with intrauterine growth restriction
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| Format: | Artículo científico |
| Language: | en |
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Universidad del Valle
2012
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| _version_ | 1876430104188420096 |
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| author | Paola Ayala Ramírez |
| author_facet | Paola Ayala Ramírez |
| contents | Identification of messenger RNA of fetoplacental source in maternal plasma of women with normal pregnancies and pregnancies with intrauterine growth restriction Paola Ayala Ramírez Reggie García Robles Juan Diego Rojas Martha Bermúdez Jaime Bernal Medicina RCIU plasma Messenger RNA pregnancy complications human placental lactogen Objective: to quantify placenta-specific RNA in plasma of women carrying foetuses with intrauterine growth restriction and pregnant women with normal pregnancies. Materials and methods: 8 pregnant women with foetuses with intrauterine growth restriction were studied as well as 18 women with uncomplicated pregnancies in the third pregnancy trimester. Total free RNA was quantified in maternal plasma by spectrophotometry and the gene expression of hPL (Human Placental Lactogen) at the messenger RNA level through technical Real Time-Chain Reaction Polymerase. Results: plasma RNA of fetoplacental origin was successfully detected in 100% of pregnant women. There were no statistically significant differences between the values of total RNA extracted from plasma (p = 0.5975) nor in the messenger RNA expression of hPL gene (p = 0.5785) between cases and controls. Conclusion: messenger RNA of fetoplacental origin can be detected in maternal plasma during pregnancy. 2012 artículo científico 0120-8322 https://www.redalyc.org/articulo.oa?id=28323958008 https://www.redalyc.org/journal/283/28323958008/ https://www.redalyc.org/journal/283/28323958008/html/ https://www.redalyc.org/journal/283/28323958008/28323958008.epub https://www.redalyc.org/journal/283/28323958008/movil en http://www.redalyc.org/revista.oa?id=283 Colombia Médica application/pdf Universidad del Valle Colombia Médica (Colombia) Num.3 Vol.43 |
| format | Artículo científico |
| id | redalyc_28323958008 |
| institution | Redalyc |
| language | en |
| publishDate | 2012 |
| publisher | Universidad del Valle |
| spellingShingle | Identification of messenger RNA of fetoplacental source in maternal plasma of women with normal pregnancies and pregnancies with intrauterine growth restriction Paola Ayala Ramírez Medicina RCIU plasma Messenger RNA pregnancy complications human placental lactogen Identification of messenger RNA of fetoplacental source in maternal plasma of women with normal pregnancies and pregnancies with intrauterine growth restriction Paola Ayala Ramírez Reggie García Robles Juan Diego Rojas Martha Bermúdez Jaime Bernal Medicina RCIU plasma Messenger RNA pregnancy complications human placental lactogen Objective: to quantify placenta-specific RNA in plasma of women carrying foetuses with intrauterine growth restriction and pregnant women with normal pregnancies. Materials and methods: 8 pregnant women with foetuses with intrauterine growth restriction were studied as well as 18 women with uncomplicated pregnancies in the third pregnancy trimester. Total free RNA was quantified in maternal plasma by spectrophotometry and the gene expression of hPL (Human Placental Lactogen) at the messenger RNA level through technical Real Time-Chain Reaction Polymerase. Results: plasma RNA of fetoplacental origin was successfully detected in 100% of pregnant women. There were no statistically significant differences between the values of total RNA extracted from plasma (p = 0.5975) nor in the messenger RNA expression of hPL gene (p = 0.5785) between cases and controls. Conclusion: messenger RNA of fetoplacental origin can be detected in maternal plasma during pregnancy. 2012 artículo científico 0120-8322 https://www.redalyc.org/articulo.oa?id=28323958008 https://www.redalyc.org/journal/283/28323958008/ https://www.redalyc.org/journal/283/28323958008/html/ https://www.redalyc.org/journal/283/28323958008/28323958008.epub https://www.redalyc.org/journal/283/28323958008/movil en http://www.redalyc.org/revista.oa?id=283 Colombia Médica application/pdf Universidad del Valle Colombia Médica (Colombia) Num.3 Vol.43 |
| title | Identification of messenger RNA of fetoplacental source in maternal plasma of women with normal pregnancies and pregnancies with intrauterine growth restriction |
| topic | Medicina RCIU plasma Messenger RNA pregnancy complications human placental lactogen |
| url | https://www.redalyc.org/articulo.oa?id=28323958008 https://www.redalyc.org/journal/283/28323958008/ https://www.redalyc.org/journal/283/28323958008/html/ https://www.redalyc.org/journal/283/28323958008/28323958008.epub https://www.redalyc.org/journal/283/28323958008/movil |