Malaria vaccines: high-throughput tools for antigen discovery with development potential
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Redalyc
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| Format: | Artículo científico |
| Language: | en |
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Universidad del Valle
2013
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| _version_ | 1876433248641351680 |
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| author | Nora Céspedes |
| author_facet | Nora Céspedes |
| contents | Malaria vaccines: high-throughput tools for antigen discovery with development potential Nora Céspedes Andrés Vallejo Myriam Arévalo-Herrera Sócrates Herrera Medicina Malaria vaccines Antigens Peptides Plasmodium Malaria is a disease induced by parasites of the Plasmodium genus, which are transmitted by Anopheles mosquitoes and represents a great socio-economic burden worldwide. Plasmodium vivax is the second species of malaria worldwide, but it is the most prevalent in Latin America and other regions of the planet. It is currently considered that vaccines represent a cost-effective strategy for controlling transmissible diseases and could complement other malaria control measures; however, the chemical and immunological complexity of the parasite has hindered development of effective vaccines. Recent availability of several genomes of Plasmodium species, as well as bioinformatics tools are allowing the selection of large numbers of proteins and analysis of their immune potential. Herein, we review recently developed strategies for discovery of novel antigens with potential for malaria vaccine development. 2013 artículo científico 0120-8322 https://www.redalyc.org/articulo.oa?id=28327007010 https://www.redalyc.org/journal/283/28327007010/ https://www.redalyc.org/journal/283/28327007010/html/ https://www.redalyc.org/journal/283/28327007010/28327007010.epub https://www.redalyc.org/journal/283/28327007010/movil en http://www.redalyc.org/revista.oa?id=283 Colombia Médica application/pdf Universidad del Valle Colombia Médica (Colombia) Num.2 Vol.44 |
| format | Artículo científico |
| id | redalyc_28327007010 |
| institution | Redalyc |
| language | en |
| publishDate | 2013 |
| publisher | Universidad del Valle |
| spellingShingle | Malaria vaccines: high-throughput tools for antigen discovery with development potential Nora Céspedes Medicina Malaria vaccines Antigens Peptides Plasmodium Malaria vaccines: high-throughput tools for antigen discovery with development potential Nora Céspedes Andrés Vallejo Myriam Arévalo-Herrera Sócrates Herrera Medicina Malaria vaccines Antigens Peptides Plasmodium Malaria is a disease induced by parasites of the Plasmodium genus, which are transmitted by Anopheles mosquitoes and represents a great socio-economic burden worldwide. Plasmodium vivax is the second species of malaria worldwide, but it is the most prevalent in Latin America and other regions of the planet. It is currently considered that vaccines represent a cost-effective strategy for controlling transmissible diseases and could complement other malaria control measures; however, the chemical and immunological complexity of the parasite has hindered development of effective vaccines. Recent availability of several genomes of Plasmodium species, as well as bioinformatics tools are allowing the selection of large numbers of proteins and analysis of their immune potential. Herein, we review recently developed strategies for discovery of novel antigens with potential for malaria vaccine development. 2013 artículo científico 0120-8322 https://www.redalyc.org/articulo.oa?id=28327007010 https://www.redalyc.org/journal/283/28327007010/ https://www.redalyc.org/journal/283/28327007010/html/ https://www.redalyc.org/journal/283/28327007010/28327007010.epub https://www.redalyc.org/journal/283/28327007010/movil en http://www.redalyc.org/revista.oa?id=283 Colombia Médica application/pdf Universidad del Valle Colombia Médica (Colombia) Num.2 Vol.44 |
| title | Malaria vaccines: high-throughput tools for antigen discovery with development potential |
| topic | Medicina Malaria vaccines Antigens Peptides Plasmodium |
| url | https://www.redalyc.org/articulo.oa?id=28327007010 https://www.redalyc.org/journal/283/28327007010/ https://www.redalyc.org/journal/283/28327007010/html/ https://www.redalyc.org/journal/283/28327007010/28327007010.epub https://www.redalyc.org/journal/283/28327007010/movil |