The effects of Plasmodium vivax gestational malaria on the clinical and immune status of pregnant women in Northwestern Colombia
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| Format: | Artículo científico |
| Sprache: | en |
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Universidad del Valle
2013
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| _version_ | 1876467550768857088 |
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| author | María Fernanda Yasnot |
| author_facet | María Fernanda Yasnot |
| contents | The effects of Plasmodium vivax gestational malaria on the clinical and immune status of pregnant women in Northwestern Colombia María Fernanda Yasnot Douglas Jay Perkins Mauricio Corredor Stephanie Yanow Jaime Carmona-Fonseca Amanda Maestre Medicina malaria placenta cytokine Colombia pregnancy Objetive: The study explored the effects of Plasmodium vivax infection on the balance of pro- versus anti- in- flammatory cytokines and chemokines and their rela- tionship with some clinical and epidemiology outcomes. Methods: Thirty-five pregnant women were recruited. Of these, 15 subjects had malaria at delivery (GM+), and 20 had no exposition to infection throughout the pregnancy (GM-) and at delivery. Epidemiological and clinical data were recorded after reviewing the clinical re- cords. At delivery, whole blood from the mother as well as placental tissue was collected. Diagnosis of infection was performed by thick smear and a polymerase chain reaction (PCR). Expression of pro-inflammatory and anti-inflammatory cytokines and chemokines was mea- sured by a real time PCR. Results: The clinical and epidemiological variables explored were similar in both groups, with the exception of gestational age. When comparing the GM+ group with the GM- group, it is clear that although the differencesgenerally are not significant, pro- inflammatory cytoki- nes are elevated in both maternal blood and placental; anti-inflammatory ones are elevated in the mother and reduced in the placenta, and the chemokines are reduced in both compartments, except for MCP-1 which is elevated in all. Conclusion: The results appear to be strongly affected bythe small number of women with GM by P. vivax at childbirth. Additional studies are needed with larger groups in this and other regions of the country. 2013 artículo científico 0120-8322 https://www.redalyc.org/articulo.oa?id=28328400007 https://www.redalyc.org/journal/283/28328400007/ https://www.redalyc.org/journal/283/28328400007/html/ https://www.redalyc.org/journal/283/28328400007/28328400007.epub https://www.redalyc.org/journal/283/28328400007/movil en http://www.redalyc.org/revista.oa?id=283 Colombia Médica application/pdf Universidad del Valle Colombia Médica (Colombia) Num.3 Vol.44 |
| format | Artículo científico |
| id | redalyc_28328400007 |
| institution | Redalyc |
| language | en |
| publishDate | 2013 |
| publisher | Universidad del Valle |
| spellingShingle | The effects of Plasmodium vivax gestational malaria on the clinical and immune status of pregnant women in Northwestern Colombia María Fernanda Yasnot Medicina malaria placenta cytokine Colombia pregnancy The effects of Plasmodium vivax gestational malaria on the clinical and immune status of pregnant women in Northwestern Colombia María Fernanda Yasnot Douglas Jay Perkins Mauricio Corredor Stephanie Yanow Jaime Carmona-Fonseca Amanda Maestre Medicina malaria placenta cytokine Colombia pregnancy Objetive: The study explored the effects of Plasmodium vivax infection on the balance of pro- versus anti- in- flammatory cytokines and chemokines and their rela- tionship with some clinical and epidemiology outcomes. Methods: Thirty-five pregnant women were recruited. Of these, 15 subjects had malaria at delivery (GM+), and 20 had no exposition to infection throughout the pregnancy (GM-) and at delivery. Epidemiological and clinical data were recorded after reviewing the clinical re- cords. At delivery, whole blood from the mother as well as placental tissue was collected. Diagnosis of infection was performed by thick smear and a polymerase chain reaction (PCR). Expression of pro-inflammatory and anti-inflammatory cytokines and chemokines was mea- sured by a real time PCR. Results: The clinical and epidemiological variables explored were similar in both groups, with the exception of gestational age. When comparing the GM+ group with the GM- group, it is clear that although the differencesgenerally are not significant, pro- inflammatory cytoki- nes are elevated in both maternal blood and placental; anti-inflammatory ones are elevated in the mother and reduced in the placenta, and the chemokines are reduced in both compartments, except for MCP-1 which is elevated in all. Conclusion: The results appear to be strongly affected bythe small number of women with GM by P. vivax at childbirth. Additional studies are needed with larger groups in this and other regions of the country. 2013 artículo científico 0120-8322 https://www.redalyc.org/articulo.oa?id=28328400007 https://www.redalyc.org/journal/283/28328400007/ https://www.redalyc.org/journal/283/28328400007/html/ https://www.redalyc.org/journal/283/28328400007/28328400007.epub https://www.redalyc.org/journal/283/28328400007/movil en http://www.redalyc.org/revista.oa?id=283 Colombia Médica application/pdf Universidad del Valle Colombia Médica (Colombia) Num.3 Vol.44 |
| title | The effects of Plasmodium vivax gestational malaria on the clinical and immune status of pregnant women in Northwestern Colombia |
| topic | Medicina malaria placenta cytokine Colombia pregnancy |
| url | https://www.redalyc.org/articulo.oa?id=28328400007 https://www.redalyc.org/journal/283/28328400007/ https://www.redalyc.org/journal/283/28328400007/html/ https://www.redalyc.org/journal/283/28328400007/28328400007.epub https://www.redalyc.org/journal/283/28328400007/movil |