Saved in:
| Main Author: | |
|---|---|
| Format: | Artículo científico |
| Language: | en |
| Published: |
Universidad del Valle
2007
|
| Subjects: | |
| Online Access: | https://www.redalyc.org/articulo.oa?id=28338102 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1866814082791768064 |
|---|---|
| author | Innocent Onyesom |
| author_facet | Innocent Onyesom |
| contents | Effect of acute dose of alcohol on the biochemical features of syndrome X in different categories of male and female Nigerian drinkers in apparent good health Innocent Onyesom Ugochukwu E. Uzuegbu Godwin E. Umukoro Medicina Glucose Alcohol Syndrome X Blood pressure Triacylglycerol Background: «Syndrome X», known since the 1980s is a disease condition precipitated by insulin resistance. Insulin resistancecauses glucose and insulin to accumulate in the blood. Syndrome X is characterized by abnormal values of triacylglycerol (TAG),blood pressure (BP), glucose and HDL-cholesterol-all risk factors for heart disease. Insulin resistance may be exacerbated by baddiet, poor lifestyle, absence of physical activity, genetic predisposition and being overweight. However, recent reports have shownthat poor lifestyle is likely to be the main cause rather than bad diet or being overweight. Even though heavy consumption of alcoholcould be regarded as a poor lifestyle, its relationship to the biochemical features and symptoms of syndrome X in both gendersis yet to be properly documented among Nigerian drinkers of alcohol.Methods: To establish a baseline information on the relationship between alcohol consumption and Syndrome X amongNigerians, two hundred and seventy-four consenting individuals in apparent good health and who were either light (53 male, 44female), moderate (51 male, 42 female) or heavy (46 male, 38 female) drinkers of alcohol were selected. They had no personal or familialhistory of CHD, stroke, cancer or related diseases. The drinkers were tested using an acute dose (1 g ethanol/kg body weight) ofalcohol.Results: Results show that the administered acute dose (1 g ethanol/kg body weight) increased serum glucose, (p>0.05), TAG(p<0.05) and BP (p<0.05) (some biochemical risk factors of Syndrome X) in both genders irrespective of the drinking category.However, alcohol-induced changes were highest among the female heavy drinkers. Thus, observations from this study suggestthat heavy consumption of alcohol by especially the female folk could alter the pathways that metabolize carbohydrates and lipidsand this may increase the risk of Syndrome X.Conclusions: Based on the available evidence, it would be reasonable to conclude that heavy consumption of alcohol byNigerian women especially may be yet another predisposing lifestyle to Syndrome X. The incidence of Syndrome X among drinkersof alcohol should be further investigated in order to provide clues to the underlying molecular mechanisms. This is important inorder to strategize therapeutic approaches, since individuals with the disease may not recognize it 2007 artículo científico 0120-8322 https://www.redalyc.org/articulo.oa?id=28338102 en http://www.redalyc.org/revista.oa?id=283 Colombia Médica application/pdf Universidad del Valle Colombia Médica (Colombia) Num.1 Vol.38 |
| format | Artículo científico |
| id | redalyc_28338102 |
| language | en |
| publishDate | 2007 |
| publisher | Universidad del Valle |
| spellingShingle | Effect of acute dose of alcohol on the biochemical features of syndrome X in different categories of male and female Nigerian drinkers in apparent good health Innocent Onyesom Medicina Glucose Alcohol Syndrome X Blood pressure Triacylglycerol Effect of acute dose of alcohol on the biochemical features of syndrome X in different categories of male and female Nigerian drinkers in apparent good health Innocent Onyesom Ugochukwu E. Uzuegbu Godwin E. Umukoro Medicina Glucose Alcohol Syndrome X Blood pressure Triacylglycerol Background: «Syndrome X», known since the 1980s is a disease condition precipitated by insulin resistance. Insulin resistancecauses glucose and insulin to accumulate in the blood. Syndrome X is characterized by abnormal values of triacylglycerol (TAG),blood pressure (BP), glucose and HDL-cholesterol-all risk factors for heart disease. Insulin resistance may be exacerbated by baddiet, poor lifestyle, absence of physical activity, genetic predisposition and being overweight. However, recent reports have shownthat poor lifestyle is likely to be the main cause rather than bad diet or being overweight. Even though heavy consumption of alcoholcould be regarded as a poor lifestyle, its relationship to the biochemical features and symptoms of syndrome X in both gendersis yet to be properly documented among Nigerian drinkers of alcohol.Methods: To establish a baseline information on the relationship between alcohol consumption and Syndrome X amongNigerians, two hundred and seventy-four consenting individuals in apparent good health and who were either light (53 male, 44female), moderate (51 male, 42 female) or heavy (46 male, 38 female) drinkers of alcohol were selected. They had no personal or familialhistory of CHD, stroke, cancer or related diseases. The drinkers were tested using an acute dose (1 g ethanol/kg body weight) ofalcohol.Results: Results show that the administered acute dose (1 g ethanol/kg body weight) increased serum glucose, (p>0.05), TAG(p<0.05) and BP (p<0.05) (some biochemical risk factors of Syndrome X) in both genders irrespective of the drinking category.However, alcohol-induced changes were highest among the female heavy drinkers. Thus, observations from this study suggestthat heavy consumption of alcohol by especially the female folk could alter the pathways that metabolize carbohydrates and lipidsand this may increase the risk of Syndrome X.Conclusions: Based on the available evidence, it would be reasonable to conclude that heavy consumption of alcohol byNigerian women especially may be yet another predisposing lifestyle to Syndrome X. The incidence of Syndrome X among drinkersof alcohol should be further investigated in order to provide clues to the underlying molecular mechanisms. This is important inorder to strategize therapeutic approaches, since individuals with the disease may not recognize it 2007 artículo científico 0120-8322 https://www.redalyc.org/articulo.oa?id=28338102 en http://www.redalyc.org/revista.oa?id=283 Colombia Médica application/pdf Universidad del Valle Colombia Médica (Colombia) Num.1 Vol.38 |
| title | Effect of acute dose of alcohol on the biochemical features of syndrome X in different categories of male and female Nigerian drinkers in apparent good health |
| topic | Medicina Glucose Alcohol Syndrome X Blood pressure Triacylglycerol |
| url | https://www.redalyc.org/articulo.oa?id=28338102 |