Evaluation of the antiamnesic effects of Phyllanthus amarus in mice
Fuente:
Redalyc
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Artículo científico |
| Sprache: | en |
| Veröffentlicht: |
Universidad del Valle
2007
|
| Schlagworte: | |
| Online-Zugang: | |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| _version_ | 1876468613679939584 |
|---|---|
| author | Hanumanthachar Joshi |
| author_facet | Hanumanthachar Joshi |
| contents | Evaluation of the antiamnesic effects of Phyllanthus amarus in mice Hanumanthachar Joshi Milind Parle Medicina Memory Amnesia Scopolamine Alzheimer´s disease is a progressive neurodegenerative disorder characterized by a gradual decline in memory. Phyllanhusamarus is commonly known as bhumi amla in India and is traditionally used since centuries in ayurveda medicine. The presentstudy was undertaken to investigate the effects of Phyllanhus amarus (PA) on cognitive functions and brain cholinesterase activityin mice. Elevated plus maze and passive avoidance paradigm were employed to evaluate learning and memory parameters. Threedoses (50, 100 and 200 mg/kg, p.o.) of aqueous extract of PA were administered for 8 successive days to both young and aged mice.PA (50, 100 and 200 mg/kg) produced a dose-dependent improvement in memory scores of young and older mice. PA also reversedsuccessfully the amnesia induced by scopolamine (0.4 mg/kg, i.p.) and diazepam (1 mg/kg, i.p.). Interestingly, brain acetylcholinesterase activity was also reduced. The underlying mechanism of action for the observed nootropic effect may be attributedto pro-cholinergic activity exhibited by PA in the present study. Therefore, it would be worthwhile to explore the therapeuticpotential of PA in the management of patients with cognitive disorders 2007 artículo científico 0120-8322 https://www.redalyc.org/articulo.oa?id=28338205 en http://www.redalyc.org/revista.oa?id=283 Colombia Médica application/pdf Universidad del Valle Colombia Médica (Colombia) Num.2 Vol.38 |
| format | Artículo científico |
| id | redalyc_28338205 |
| institution | Redalyc |
| language | en |
| publishDate | 2007 |
| publisher | Universidad del Valle |
| spellingShingle | Evaluation of the antiamnesic effects of Phyllanthus amarus in mice Hanumanthachar Joshi Medicina Memory Amnesia Scopolamine Evaluation of the antiamnesic effects of Phyllanthus amarus in mice Hanumanthachar Joshi Milind Parle Medicina Memory Amnesia Scopolamine Alzheimer´s disease is a progressive neurodegenerative disorder characterized by a gradual decline in memory. Phyllanhusamarus is commonly known as bhumi amla in India and is traditionally used since centuries in ayurveda medicine. The presentstudy was undertaken to investigate the effects of Phyllanhus amarus (PA) on cognitive functions and brain cholinesterase activityin mice. Elevated plus maze and passive avoidance paradigm were employed to evaluate learning and memory parameters. Threedoses (50, 100 and 200 mg/kg, p.o.) of aqueous extract of PA were administered for 8 successive days to both young and aged mice.PA (50, 100 and 200 mg/kg) produced a dose-dependent improvement in memory scores of young and older mice. PA also reversedsuccessfully the amnesia induced by scopolamine (0.4 mg/kg, i.p.) and diazepam (1 mg/kg, i.p.). Interestingly, brain acetylcholinesterase activity was also reduced. The underlying mechanism of action for the observed nootropic effect may be attributedto pro-cholinergic activity exhibited by PA in the present study. Therefore, it would be worthwhile to explore the therapeuticpotential of PA in the management of patients with cognitive disorders 2007 artículo científico 0120-8322 https://www.redalyc.org/articulo.oa?id=28338205 en http://www.redalyc.org/revista.oa?id=283 Colombia Médica application/pdf Universidad del Valle Colombia Médica (Colombia) Num.2 Vol.38 |
| title | Evaluation of the antiamnesic effects of Phyllanthus amarus in mice |
| topic | Medicina Memory Amnesia Scopolamine |
| url | https://www.redalyc.org/articulo.oa?id=28338205 |