Amyloid-beta immunotherapy: the hope for Alzheimer disease?
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Redalyc
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| Formato: | Artículo científico |
| Lenguaje: | en |
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Universidad del Valle
2016
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| _version_ | 1876460066233647104 |
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| author | Alvaro Barrera-Ocampo |
| author_facet | Alvaro Barrera-Ocampo |
| contents | Amyloid-beta immunotherapy: the hope for Alzheimer disease? Alvaro Barrera-Ocampo Francisco Lopera Medicina adult Peptides antibodies Vaccination Amyloid beta Alzheimer disease (AD) is the most prevalent form of dementia of adult-onset, characterized by progressive impairment in cognition and memory. There is no cure for the disease and the current treatments are only symptomatic. Drug discovery is an expensive and time-consuming process; in the last decade no new drugs have been found for AD despite the efforts of the scientific community and pharmaceutical companies. The Aβ immunotherapy is one of the most promising approaches to modify the course of AD. This therapeutic strategy uses synthetic peptides or monoclonal antibodies (mAb) to decrease the Aβ load in the brain and slow the progression of the disease. Therefore, this article will discuss the main aspects of AD neuropathogenesis, the classical pharmacologic treatment, as well as the active and passive immunization describing drug prototypes evaluated in different clinical trials. 2016 artículo científico 0120-8322 https://www.redalyc.org/articulo.oa?id=28349362005 https://www.redalyc.org/journal/283/28349362005/ https://www.redalyc.org/journal/283/28349362005/html/ https://www.redalyc.org/journal/283/28349362005/28349362005.epub https://www.redalyc.org/journal/283/28349362005/movil en http://www.redalyc.org/revista.oa?id=283 Colombia Médica application/pdf Universidad del Valle Colombia Médica (Colombia) Num.4 Vol.47 |
| format | Artículo científico |
| id | redalyc_28349362005 |
| institution | Redalyc |
| language | en |
| publishDate | 2016 |
| publisher | Universidad del Valle |
| spellingShingle | Amyloid-beta immunotherapy: the hope for Alzheimer disease? Alvaro Barrera-Ocampo Medicina adult Peptides antibodies Vaccination Amyloid beta Amyloid-beta immunotherapy: the hope for Alzheimer disease? Alvaro Barrera-Ocampo Francisco Lopera Medicina adult Peptides antibodies Vaccination Amyloid beta Alzheimer disease (AD) is the most prevalent form of dementia of adult-onset, characterized by progressive impairment in cognition and memory. There is no cure for the disease and the current treatments are only symptomatic. Drug discovery is an expensive and time-consuming process; in the last decade no new drugs have been found for AD despite the efforts of the scientific community and pharmaceutical companies. The Aβ immunotherapy is one of the most promising approaches to modify the course of AD. This therapeutic strategy uses synthetic peptides or monoclonal antibodies (mAb) to decrease the Aβ load in the brain and slow the progression of the disease. Therefore, this article will discuss the main aspects of AD neuropathogenesis, the classical pharmacologic treatment, as well as the active and passive immunization describing drug prototypes evaluated in different clinical trials. 2016 artículo científico 0120-8322 https://www.redalyc.org/articulo.oa?id=28349362005 https://www.redalyc.org/journal/283/28349362005/ https://www.redalyc.org/journal/283/28349362005/html/ https://www.redalyc.org/journal/283/28349362005/28349362005.epub https://www.redalyc.org/journal/283/28349362005/movil en http://www.redalyc.org/revista.oa?id=283 Colombia Médica application/pdf Universidad del Valle Colombia Médica (Colombia) Num.4 Vol.47 |
| title | Amyloid-beta immunotherapy: the hope for Alzheimer disease? |
| topic | Medicina adult Peptides antibodies Vaccination Amyloid beta |
| url | https://www.redalyc.org/articulo.oa?id=28349362005 https://www.redalyc.org/journal/283/28349362005/ https://www.redalyc.org/journal/283/28349362005/html/ https://www.redalyc.org/journal/283/28349362005/28349362005.epub https://www.redalyc.org/journal/283/28349362005/movil |