Sodium thiosulfate and pamidronate for treatment of calciphylaxis: case report
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| Format: | Artículo científico |
| Language: | en |
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Universidad del Valle
2018
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| author | Sonia Fernández Cañabate |
| author_facet | Sonia Fernández Cañabate |
| contents | Sodium thiosulfate and pamidronate for treatment of calciphylaxis: case report Sonia Fernández Cañabate Cristina Lucas Alvarez Luis Ortega Valin Jorge Estifan Ksabji Medicina Arterioles pamidronate Calciphylaxis Hypoalbuminemia Hyperphosphatemia Introduction: Calciphylaxis is an infrequent disease that almost exclusively affects patients with chronic kidney disease, although cases have been observed in patients without renal function impairment. The diagnosis is mainly made by clinical manifestations and subsequently confirmed by radiological and histological study. The optimal treatment is not known, although there is a consensus that a multifactorial approach is required.Clinical Case: A 68-year-old woman on hemodialysis for 2 years, who presented a painful nodular lesion in the left thigh, a skin biopsy was performed resulting in a diagnosis of calciphylaxis. Treatment and Outcome: Treatment was started with intravenous sodium thiosulfate. Pamidronate is added intravenously, three months later, due to an unfavorable evolution. After 6 months of treatment, improvement in nodular lesions and healing of the ulcerated lesion was observed to be generally well tolerated treatment.Conclusion: The combined treatment of sodium thiosulfate, pamidronate and calcitomimetics has been effectiveand safe for the treatment of calciphylaxis, inducing complete remission. 2018 otro 0120-8322 https://www.redalyc.org/articulo.oa?id=28358186007 https://www.redalyc.org/journal/283/28358186007/ https://www.redalyc.org/journal/283/28358186007/html/ https://www.redalyc.org/journal/283/28358186007/28358186007.epub https://www.redalyc.org/journal/283/28358186007/movil 10.25100/cm.v49i3.4134 en http://www.redalyc.org/revista.oa?id=283 Colombia Médica application/pdf Universidad del Valle Colombia Médica (Colombia) Num.4 Vol.49 |
| format | Artículo científico |
| id | redalyc_28358186007 |
| institution | Redalyc |
| language | en |
| publishDate | 2018 |
| publisher | Universidad del Valle |
| spellingShingle | Sodium thiosulfate and pamidronate for treatment of calciphylaxis: case report Sonia Fernández Cañabate Medicina Arterioles pamidronate Calciphylaxis Hypoalbuminemia Hyperphosphatemia Sodium thiosulfate and pamidronate for treatment of calciphylaxis: case report Sonia Fernández Cañabate Cristina Lucas Alvarez Luis Ortega Valin Jorge Estifan Ksabji Medicina Arterioles pamidronate Calciphylaxis Hypoalbuminemia Hyperphosphatemia Introduction: Calciphylaxis is an infrequent disease that almost exclusively affects patients with chronic kidney disease, although cases have been observed in patients without renal function impairment. The diagnosis is mainly made by clinical manifestations and subsequently confirmed by radiological and histological study. The optimal treatment is not known, although there is a consensus that a multifactorial approach is required.Clinical Case: A 68-year-old woman on hemodialysis for 2 years, who presented a painful nodular lesion in the left thigh, a skin biopsy was performed resulting in a diagnosis of calciphylaxis. Treatment and Outcome: Treatment was started with intravenous sodium thiosulfate. Pamidronate is added intravenously, three months later, due to an unfavorable evolution. After 6 months of treatment, improvement in nodular lesions and healing of the ulcerated lesion was observed to be generally well tolerated treatment.Conclusion: The combined treatment of sodium thiosulfate, pamidronate and calcitomimetics has been effectiveand safe for the treatment of calciphylaxis, inducing complete remission. 2018 otro 0120-8322 https://www.redalyc.org/articulo.oa?id=28358186007 https://www.redalyc.org/journal/283/28358186007/ https://www.redalyc.org/journal/283/28358186007/html/ https://www.redalyc.org/journal/283/28358186007/28358186007.epub https://www.redalyc.org/journal/283/28358186007/movil 10.25100/cm.v49i3.4134 en http://www.redalyc.org/revista.oa?id=283 Colombia Médica application/pdf Universidad del Valle Colombia Médica (Colombia) Num.4 Vol.49 |
| title | Sodium thiosulfate and pamidronate for treatment of calciphylaxis: case report |
| topic | Medicina Arterioles pamidronate Calciphylaxis Hypoalbuminemia Hyperphosphatemia |
| url | https://www.redalyc.org/articulo.oa?id=28358186007 https://www.redalyc.org/journal/283/28358186007/ https://www.redalyc.org/journal/283/28358186007/html/ https://www.redalyc.org/journal/283/28358186007/28358186007.epub https://www.redalyc.org/journal/283/28358186007/movil |