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| Format: | Artículo científico |
| Sprache: | en |
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Sociedade Portuguesa de Psicossomática
2005
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| Online-Zugang: | https://www.redalyc.org/articulo.oa?id=28770206 |
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Inhaltsangabe:
- Depression and interferon therapy in chronic hepatitis C patients: epidemiology, predictive factors and proposed etiopathogenic models António Cruz Neves Christopher Dickens Miguel Xavier Psicología Inter feron Depression Hepatitis C alpha therapy Objective: Neuropsychiatric symptoms are commonly associated with chronic hepatitis C virus infection and its treatment. In particular, interferon,a primary component of treatment forchronic hepatitis C, has been strongly associated with depressive symptoms.The aim of this review of the literature was to evaluate the incidence of depression and related predictive factors inpatients with hepatitis C on interferon alpha therapy and the proposed etiopathogenic models.Method: A review of the literature was undertaken.Results: An increase in depressionor in psychiatric disturbance in general during therapy with IFN alpha wasfound - reported rates of interferon al-pha-induced Major Depressive Disorder have ranged from 10% to 44% across studies. It appears that the development of depression in chronic hepatitis C patients treated with IFN alpha may be dependent on both duration of treatment and dosage of IFN alpha. Regarding the ascertainment of predictive factors for depression, the findings are not conclusive and sometimes contradictory. Conclusions: More studies are needed in order to clarify the possiblel inks and associations between INF use and depression. Further more, researchis needed so that patients with psychiat-ric problems are not excluded from effective treatments for this growing medical problem. 2005 artículo científico 0874-4696 https://www.redalyc.org/articulo.oa?id=28770206 en http://www.redalyc.org/revista.oa?id=287 Revista Portuguesa de Psicossomática application/pdf Sociedade Portuguesa de Psicossomática Revista Portuguesa de Psicossomática (Portugal) Num.1-2 Vol.7