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| Autore principale: | |
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| Natura: | Artículo científico |
| Lingua: | en |
| Pubblicazione: |
Universidad del Valle
2017
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| Accesso online: | https://www.redalyc.org/articulo.oa?id=291354828003 https://www.redalyc.org/journal/2913/291354828003/ https://www.redalyc.org/journal/2913/291354828003/html/ https://www.redalyc.org/journal/2913/291354828003/291354828003.epub https://www.redalyc.org/journal/2913/291354828003/movil |
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Sommario:
- Remote-3DD: a new remote homology detection method that uses physicochemical properties Oscar F. Bedoya Ingeniería classifiers SCOP dataset Bioinformatics remote homologs physicochemical properties In this paper, we present a new method for remote homology detection called remote-3DD. The proposed method combines predicted contact maps and distributions of the interaction matrices. Predicted contact maps approximate the 3D shape of a protein based on its primary structure. On the other hand, an interaction matrix allows representing a protein by using the physicochemical properties of its amino acids. The remote-3DD method is proposed as a strategy to improve the accuracy of the remote-C3D method, which uses contact maps alone. In this paper, we hypothesize that we can improve the accuracy of the remote-C3D method by including physicochemical properties. The results show that the accuracy of the remote-3DD method is higher than the accuracy of the composition-based methods and in some cases comparable with the accuracy of the profile-based methods. In addition, the results also show that the remote-3DD method achieves higher accuracy values than the remote-C3D method when considering the same number of models and size of submatrices. 2017 artículo científico 0123-3033 https://www.redalyc.org/articulo.oa?id=291354828003 https://www.redalyc.org/journal/2913/291354828003/ https://www.redalyc.org/journal/2913/291354828003/html/ https://www.redalyc.org/journal/2913/291354828003/291354828003.epub https://www.redalyc.org/journal/2913/291354828003/movil 10.25100/iyc.v19i2.5289 en http://www.redalyc.org/revista.oa?id=2913 Ingeniería y Competitividad application/pdf Universidad del Valle Ingeniería y Competitividad (Colombia) Num.2 Vol.19