Subset selection of markers for the genome-enabled prediction of genetic values using radial basis function neural networks
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| Format: | Artículo científico |
| Sprache: | en |
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Universidade Estadual de Maringá
2021
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| _version_ | 1876456948729118720 |
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| author | Isabela de Castro Sant’Anna |
| author_facet | Isabela de Castro Sant’Anna |
| contents | Subset selection of markers for the genome-enabled prediction of genetic values using radial basis function neural networks Isabela de Castro Sant’Anna Gabi Nunes Silva Moysés Nascimento Cosme Damião Cruz Agrociencias Neural networks genomic prediction stepwise regression This paper aimed to evaluate the effectiveness of subset selection of markers for genome-enabled prediction of genetic values using radial basis function neural networks (RBFNN). To this end, an F1 population derived from the hybridization of divergent parents with 500 individuals genotyped with 1000 SNP-type markers was simulated. Phenotypic traits were determined by adopting three different gene action models - additive, additive-dominant, and epistatic, representing two dominance situations: partial and complete with quantitative traits having a heritability (h2) of 30 and 60%; traits were controlled by 50 loci, considering two alleles per locus. Twelve different scenarios were represented in the simulation. The stepwise regression was used before the prediction methods. The reliability and the root mean square error were used for estimation using a fivefold cross-validation scheme. Overall, dimensionality reduction improved the reliability values for all scenarios, specifically with h2 =30 the reliability value from 0.03 to 0.59 using RBFNN and from 0.10 to 0.57 with RR-BLUP in the scenario with additive effects. In the additive dominant scenario, the reliability values changed from 0.12 to 0.59 using RBFNN and from 0.12 to 0.58 with RR-BLUP, and in the epistasis scenarios, the reliability values changed from 0.07 to 0.50 using RBFNN and from 0.06 to 0.47 with RR-BLUP. The results showed that the use of stepwise regression before the use of these techniques led to an improvement in the accuracy of prediction of the genetic value and, mainly, to a large reduction of the root mean square error in addition to facilitating processing and analysis time due to a reduction in dimensionality. 2021 artículo científico 1679-9275 https://www.redalyc.org/articulo.oa?id=303067924014 https://www.redalyc.org/journal/3030/303067924014/ https://www.redalyc.org/journal/3030/303067924014/html/ https://www.redalyc.org/journal/3030/303067924014/303067924014.epub https://www.redalyc.org/journal/3030/303067924014/movil 10.4025/actasciagron.v43i1.46307 en http://www.redalyc.org/revista.oa?id=3030 Acta Scientiarum. Agronomy application/pdf Universidade Estadual de Maringá Acta Scientiarum. Agronomy (Brasil) Vol.43 |
| format | Artículo científico |
| id | redalyc_303067924014 |
| institution | Redalyc |
| language | en |
| publishDate | 2021 |
| publisher | Universidade Estadual de Maringá |
| spellingShingle | Subset selection of markers for the genome-enabled prediction of genetic values using radial basis function neural networks Isabela de Castro Sant’Anna Agrociencias Neural networks genomic prediction stepwise regression Subset selection of markers for the genome-enabled prediction of genetic values using radial basis function neural networks Isabela de Castro Sant’Anna Gabi Nunes Silva Moysés Nascimento Cosme Damião Cruz Agrociencias Neural networks genomic prediction stepwise regression This paper aimed to evaluate the effectiveness of subset selection of markers for genome-enabled prediction of genetic values using radial basis function neural networks (RBFNN). To this end, an F1 population derived from the hybridization of divergent parents with 500 individuals genotyped with 1000 SNP-type markers was simulated. Phenotypic traits were determined by adopting three different gene action models - additive, additive-dominant, and epistatic, representing two dominance situations: partial and complete with quantitative traits having a heritability (h2) of 30 and 60%; traits were controlled by 50 loci, considering two alleles per locus. Twelve different scenarios were represented in the simulation. The stepwise regression was used before the prediction methods. The reliability and the root mean square error were used for estimation using a fivefold cross-validation scheme. Overall, dimensionality reduction improved the reliability values for all scenarios, specifically with h2 =30 the reliability value from 0.03 to 0.59 using RBFNN and from 0.10 to 0.57 with RR-BLUP in the scenario with additive effects. In the additive dominant scenario, the reliability values changed from 0.12 to 0.59 using RBFNN and from 0.12 to 0.58 with RR-BLUP, and in the epistasis scenarios, the reliability values changed from 0.07 to 0.50 using RBFNN and from 0.06 to 0.47 with RR-BLUP. The results showed that the use of stepwise regression before the use of these techniques led to an improvement in the accuracy of prediction of the genetic value and, mainly, to a large reduction of the root mean square error in addition to facilitating processing and analysis time due to a reduction in dimensionality. 2021 artículo científico 1679-9275 https://www.redalyc.org/articulo.oa?id=303067924014 https://www.redalyc.org/journal/3030/303067924014/ https://www.redalyc.org/journal/3030/303067924014/html/ https://www.redalyc.org/journal/3030/303067924014/303067924014.epub https://www.redalyc.org/journal/3030/303067924014/movil 10.4025/actasciagron.v43i1.46307 en http://www.redalyc.org/revista.oa?id=3030 Acta Scientiarum. Agronomy application/pdf Universidade Estadual de Maringá Acta Scientiarum. Agronomy (Brasil) Vol.43 |
| title | Subset selection of markers for the genome-enabled prediction of genetic values using radial basis function neural networks |
| topic | Agrociencias Neural networks genomic prediction stepwise regression |
| url | https://www.redalyc.org/articulo.oa?id=303067924014 https://www.redalyc.org/journal/3030/303067924014/ https://www.redalyc.org/journal/3030/303067924014/html/ https://www.redalyc.org/journal/3030/303067924014/303067924014.epub https://www.redalyc.org/journal/3030/303067924014/movil |