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1. Verfasser:	NICOLÁS M. KOUYOUMDZIAN
Format:	Artículo científico
Sprache:	es
Veröffentlicht:	Sociedad Argentina de Cardiología 2021
Schlagworte:	Medicina Riñón Cloruro Hipertensión Glutatión peroxidasa Peroxidación de lípido
Online-Zugang:	https://www.redalyc.org/articulo.oa?id=305369821005 https://www.redalyc.org/journal/3053/305369821005/ https://www.redalyc.org/journal/3053/305369821005/html/ https://www.redalyc.org/journal/3053/305369821005/305369821005.epub https://www.redalyc.org/journal/3053/305369821005/movil
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Hacia el esclarecimiento del rol del anión cloruro en la hipertensión arterial: su vínculo con el daño oxidativo en el riñón NICOLÁS M. KOUYOUMDZIAN GABRIEL KIM GABRIEL D. ROBBESAUL PAULA D. PRINCE ANA M. PUYÓ BELISARIO E. FERNÁNDEZ MÓNICA L. GALLEANO MARCELO R. CHOI Medicina Riñón Cloruro Hipertensión Glutatión peroxidasa Peroxidación de lípido Introducción: Se desconoce el papel del anión cloruro en los efectos deletéreos del consumo excesivo de sal (NaCl) y si sus efectos son independientes de la presencia del sodio.Objetivo: Demostrar que tanto una sobrecarga de cloruro como una sobrecarga de sodio en la dieta producen efectos deletéreos, en forma independiente, sobre la presión arterial sistólica (PAS), la función renal y los marcadores de estrés oxidativo en el riñón.Materiales y métodos: Ratas Wistar macho fueron divididas en cuatro grupos (n = 8/grupo) y fueron alimentadas con diferentes dietas durante tres semanas: C: control (dieta estándar), NaCl: hipersódica-hiperclórica, Na: hipersódica sin cloruro, Cl: hiperclórica sin sodio. Se determinaron la presión arterial sistólica (PAS) y la función renal y en la corteza renal, se evaluó la producción de especies reactivas del ácido tiobarbitúrico (en inglés: TBARS) y la actividad y la expresión de las enzimas superóxido dismutasa (SOD), catalasa (CAT) y glutatión peroxidasa (GPx).Resultados: Al cabo de tres semanas, la PAS aumentó (*) en los dos grupos alimentados con cloruro. La excreción fraccional de sodio y de cloruro aumentó (*) en los grupos NaCl y Na. La diuresis y los TBARS en la corteza renal aumentaron (*) con las tres dietas, sin cambios en la actividad y en la expresión de SOD y CAT. La actividad de la GPx aumentó (*) en los dos grupos que recibieron cloruro; (*p < 0,05 vs C).Conclusión: Tanto la sobrecarga de sodio como la de cloruro se asocian a mayor estado oxidativo caracterizado por un incremento en la peroxidación lipídica en la corteza renal. Sin embargo, solo el exceso de cloruro se asocia a mayor actividad de la GPx y de la hipertensión, sin cambios en la excreción urinaria de cloruros, sugiriendo un mayor estado prooxidante renal en comparación con el grupo Na. 2021 artículo científico 0034-7000 https://www.redalyc.org/articulo.oa?id=305369821005 https://www.redalyc.org/journal/3053/305369821005/ https://www.redalyc.org/journal/3053/305369821005/html/ https://www.redalyc.org/journal/3053/305369821005/305369821005.epub https://www.redalyc.org/journal/3053/305369821005/movil 10.7775/rac.es.v89.i2.20034 es http://www.redalyc.org/revista.oa?id=3053 Revista Argentina de Cardiología application/pdf Sociedad Argentina de Cardiología Revista Argentina de Cardiología (Argentina) Num.2 Vol.89

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