Anxiolytic and sedative effects of a combined extract of Passiflora alata Dryander and Valeriana officinalis L. in rats
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| Format: | Artículo científico |
| Sprache: | en |
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Universidade Estadual de Maringá
2005
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| _version_ | 1876449257397944320 |
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| author | Fernanda Jacques Otobone |
| author_facet | Fernanda Jacques Otobone |
| contents | Anxiolytic and sedative effects of a combined extract of Passiflora alata Dryander and Valeriana officinalis L. in rats Fernanda Jacques Otobone Juliana Vanessa Colombo Martins Marcos Alberto Trombelli Roberto Andreatini Elisabeth Aparecida Audi Medicina sedative effect Anxiolytic effect Valeriana officialis L Passiflora alata Dryander This work investigated the effects of a combined extract of Passiflora alata Dryander and Valeriana officinalis L. (EPV) in rats under going elevated plus maze (EPM) and open-field test (OFT). No effects were detected after acute or repeated (3 or 7-days) treatment with EPV (5, 10 or 20 mg/kg, by gavage), on the EPM or the OFT. However, rats treated for 15 day (20 mg/kg) with EPV showed increased percentage of entries and time spent in the open arms on the EPM without alter locomotor activity in the OFT compared to control group. Acute or a 15 day administration of diazepam (2 mg/kg, i.p.), increased the same parameters on the EPM and OFT. Acute treatment with 300 or 600 mg/kg of EPV, decreased the locomotor activity in the OFT. Results suggest anxiolytic and sedative effects for the EPV and reveal a wide dose range for the anxiolytic effect. 2005 artículo científico 1679-9291 https://www.redalyc.org/articulo.oa?id=307223952007 en http://www.redalyc.org/revista.oa?id=3072 Acta Scientiarum. Health Sciences application/pdf Universidade Estadual de Maringá Acta Scientiarum. Health Sciences (Brasil) Num.2 Vol.27 |
| format | Artículo científico |
| id | redalyc_307223952007 |
| institution | Redalyc |
| language | en |
| publishDate | 2005 |
| publisher | Universidade Estadual de Maringá |
| spellingShingle | Anxiolytic and sedative effects of a combined extract of Passiflora alata Dryander and Valeriana officinalis L. in rats Fernanda Jacques Otobone Medicina sedative effect Anxiolytic effect Valeriana officialis L Passiflora alata Dryander Anxiolytic and sedative effects of a combined extract of Passiflora alata Dryander and Valeriana officinalis L. in rats Fernanda Jacques Otobone Juliana Vanessa Colombo Martins Marcos Alberto Trombelli Roberto Andreatini Elisabeth Aparecida Audi Medicina sedative effect Anxiolytic effect Valeriana officialis L Passiflora alata Dryander This work investigated the effects of a combined extract of Passiflora alata Dryander and Valeriana officinalis L. (EPV) in rats under going elevated plus maze (EPM) and open-field test (OFT). No effects were detected after acute or repeated (3 or 7-days) treatment with EPV (5, 10 or 20 mg/kg, by gavage), on the EPM or the OFT. However, rats treated for 15 day (20 mg/kg) with EPV showed increased percentage of entries and time spent in the open arms on the EPM without alter locomotor activity in the OFT compared to control group. Acute or a 15 day administration of diazepam (2 mg/kg, i.p.), increased the same parameters on the EPM and OFT. Acute treatment with 300 or 600 mg/kg of EPV, decreased the locomotor activity in the OFT. Results suggest anxiolytic and sedative effects for the EPV and reveal a wide dose range for the anxiolytic effect. 2005 artículo científico 1679-9291 https://www.redalyc.org/articulo.oa?id=307223952007 en http://www.redalyc.org/revista.oa?id=3072 Acta Scientiarum. Health Sciences application/pdf Universidade Estadual de Maringá Acta Scientiarum. Health Sciences (Brasil) Num.2 Vol.27 |
| title | Anxiolytic and sedative effects of a combined extract of Passiflora alata Dryander and Valeriana officinalis L. in rats |
| topic | Medicina sedative effect Anxiolytic effect Valeriana officialis L Passiflora alata Dryander |
| url | https://www.redalyc.org/articulo.oa?id=307223952007 |