Trypanocidal activity of genotoxic concentration of benznidazole on epimastigote forms of Trypanosoma cruzi
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| Format: | Artículo científico |
| Sprache: | en |
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Universidade Estadual de Maringá
2012
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| author | Edilson Nobuyoshi Kaneshima |
| author_facet | Edilson Nobuyoshi Kaneshima |
| contents | Trypanocidal activity of genotoxic concentration of benznidazole on epimastigote forms of Trypanosoma cruzi Edilson Nobuyoshi Kaneshima Marialba Avezum Alves Castro-Prado Max Jean de Ornelas Toledo Silvana Marques Araújo Mônica Lúcia Gomes Medicina cruzi I cruzi II Benznidazole genotoxicity Chagas' disease The genotoxicity of benznidazole at a concentration of 75 μM, used in the treatment of Chagas' disease, has been recently reported. The present study evaluated the inhibitory effect of benznidazole on the growth of epimastigote forms of T. cruzi I and II by using genotoxic (75 μM) and non- genotoxic (50 μM) concentrations. To assess the growth rates of T. cruzi strains G2, A2.1A, CL, Y, and 2052, parasites in the epimastigote form were cultured in LIT medium for 192 h at 28oC, with (50 and 75 μM) and without (negative control) benznidazole. Benznidazole at both concentrations inhibited all the strains, regardless of genetic group. In the 75 μM concentration, there was a significant decrease in the number of parasites inoculated at T0 after 96 h incubation. The results showed that although genotoxic and non-genotoxic doses of benznidazole inhibit the growth of the epimastigote forms of T. cruzi I and II, only the 75 μM dose seem to indicate a possible trypanocidal effect. 2012 artículo científico 1679-9291 https://www.redalyc.org/articulo.oa?id=307226825014 en http://www.redalyc.org/revista.oa?id=3072 Acta Scientiarum. Health Sciences application/pdf Universidade Estadual de Maringá Acta Scientiarum. Health Sciences (Brasil) Vol.34 |
| format | Artículo científico |
| id | redalyc_307226825014 |
| institution | Redalyc |
| language | en |
| publishDate | 2012 |
| publisher | Universidade Estadual de Maringá |
| spellingShingle | Trypanocidal activity of genotoxic concentration of benznidazole on epimastigote forms of Trypanosoma cruzi Edilson Nobuyoshi Kaneshima Medicina cruzi I cruzi II Benznidazole genotoxicity Chagas' disease Trypanocidal activity of genotoxic concentration of benznidazole on epimastigote forms of Trypanosoma cruzi Edilson Nobuyoshi Kaneshima Marialba Avezum Alves Castro-Prado Max Jean de Ornelas Toledo Silvana Marques Araújo Mônica Lúcia Gomes Medicina cruzi I cruzi II Benznidazole genotoxicity Chagas' disease The genotoxicity of benznidazole at a concentration of 75 μM, used in the treatment of Chagas' disease, has been recently reported. The present study evaluated the inhibitory effect of benznidazole on the growth of epimastigote forms of T. cruzi I and II by using genotoxic (75 μM) and non- genotoxic (50 μM) concentrations. To assess the growth rates of T. cruzi strains G2, A2.1A, CL, Y, and 2052, parasites in the epimastigote form were cultured in LIT medium for 192 h at 28oC, with (50 and 75 μM) and without (negative control) benznidazole. Benznidazole at both concentrations inhibited all the strains, regardless of genetic group. In the 75 μM concentration, there was a significant decrease in the number of parasites inoculated at T0 after 96 h incubation. The results showed that although genotoxic and non-genotoxic doses of benznidazole inhibit the growth of the epimastigote forms of T. cruzi I and II, only the 75 μM dose seem to indicate a possible trypanocidal effect. 2012 artículo científico 1679-9291 https://www.redalyc.org/articulo.oa?id=307226825014 en http://www.redalyc.org/revista.oa?id=3072 Acta Scientiarum. Health Sciences application/pdf Universidade Estadual de Maringá Acta Scientiarum. Health Sciences (Brasil) Vol.34 |
| title | Trypanocidal activity of genotoxic concentration of benznidazole on epimastigote forms of Trypanosoma cruzi |
| topic | Medicina cruzi I cruzi II Benznidazole genotoxicity Chagas' disease |
| url | https://www.redalyc.org/articulo.oa?id=307226825014 |