Physical and chemical analysis of commercial nystatin
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| Natura: | Artículo científico |
| Lingua: | en |
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Universidade Estadual de Maringá
2013
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| _version_ | 1876488046812069888 |
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| author | Edeilza Gomes Brescansin |
| author_facet | Edeilza Gomes Brescansin |
| contents | Physical and chemical analysis of commercial nystatin Edeilza Gomes Brescansin Márcia Portilho Francisco Benedito Teixeira Pessine Medicina Nystatin analytical control physical and chemical analyses Nystatin (NYS) is a fermentation-produced antibiotic of the polyene group. Commercial NYS is a mixture of compounds named NIS A1, A2 and A3. Current analysis undertook physical and chemical analyses in two samples of commercial nystatin (NYS I and NYS II). Moisture (Karl Fischer), spectroscopic (IR, UV and fluorescence) and thermal analyses (TGA and DSC) were conducted. The moisture was respectively 9.2% and 8.8% for samples I and II. Absorption spectrum in the UV/VIS region had a vibronic structure with three max.. The mirror image rule was not complied with in the fluorimetric analysis. Spectroscopy analysis in the IV region indicated that samples showed spectra similar one to another, analogous to crystal type A. Thermal analyses by DSC provided a wide, single endothermal peak and, therefore, similarities among the samples. DTG shows that samples undergo decomposition at three phases within the temperature range under analysis. Results show that samples are impure and not polymorphic, constituted by a mixture of the compounds A1, A2 and A3. 2013 artículo científico 1679-9291 https://www.redalyc.org/articulo.oa?id=307228854010 en http://www.redalyc.org/revista.oa?id=3072 Acta Scientiarum. Health Sciences application/pdf Universidade Estadual de Maringá Acta Scientiarum. Health Sciences (Brasil) Num.2 Vol.35 |
| format | Artículo científico |
| id | redalyc_307228854010 |
| institution | Redalyc |
| language | en |
| publishDate | 2013 |
| publisher | Universidade Estadual de Maringá |
| spellingShingle | Physical and chemical analysis of commercial nystatin Edeilza Gomes Brescansin Medicina Nystatin analytical control physical and chemical analyses Physical and chemical analysis of commercial nystatin Edeilza Gomes Brescansin Márcia Portilho Francisco Benedito Teixeira Pessine Medicina Nystatin analytical control physical and chemical analyses Nystatin (NYS) is a fermentation-produced antibiotic of the polyene group. Commercial NYS is a mixture of compounds named NIS A1, A2 and A3. Current analysis undertook physical and chemical analyses in two samples of commercial nystatin (NYS I and NYS II). Moisture (Karl Fischer), spectroscopic (IR, UV and fluorescence) and thermal analyses (TGA and DSC) were conducted. The moisture was respectively 9.2% and 8.8% for samples I and II. Absorption spectrum in the UV/VIS region had a vibronic structure with three max.. The mirror image rule was not complied with in the fluorimetric analysis. Spectroscopy analysis in the IV region indicated that samples showed spectra similar one to another, analogous to crystal type A. Thermal analyses by DSC provided a wide, single endothermal peak and, therefore, similarities among the samples. DTG shows that samples undergo decomposition at three phases within the temperature range under analysis. Results show that samples are impure and not polymorphic, constituted by a mixture of the compounds A1, A2 and A3. 2013 artículo científico 1679-9291 https://www.redalyc.org/articulo.oa?id=307228854010 en http://www.redalyc.org/revista.oa?id=3072 Acta Scientiarum. Health Sciences application/pdf Universidade Estadual de Maringá Acta Scientiarum. Health Sciences (Brasil) Num.2 Vol.35 |
| title | Physical and chemical analysis of commercial nystatin |
| topic | Medicina Nystatin analytical control physical and chemical analyses |
| url | https://www.redalyc.org/articulo.oa?id=307228854010 |