Atropine is more efficient than ZM241385 to reduce a drastic level of fade caused by cisatracurium at 50 Hz
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| Formato: | Artículo científico |
| Lenguaje: | en |
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Universidade Estadual de Maringá
2016
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| _version_ | 1876457362167955456 |
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| author | Arethusa Lobo Pimentel |
| author_facet | Arethusa Lobo Pimentel |
| contents | Atropine is more efficient than ZM241385 to reduce a drastic level of fade caused by cisatracurium at 50 Hz Arethusa Lobo Pimentel Gabriela de Castro Prado Wilson Alves-Do-Prado Célia Regina Ambiel Medicina of four train adenosine Tetanic fade The effects of atropine (non selective muscarinic antagonist) and ZM241385 (A2A receptors antagonist) in the cisatracurium-induced drastic (100%) level of fade at 50 Hz (10 s) (100% Fade) were compared in the phrenic nerve-diaphragm muscle preparations of rats indirectly stimulated at a physiological tetanic frequency (50 Hz). The lowest dose and the instant cisatracurium caused 100% Fade were investigated. Cisatracurium induced 100% Fade 15 min after being administered. Atropine reduced the cisatracurium-induced 100% Fade, but the administration of ZM241385 separately, or combined with atropine, did not cause any effect in the cisatracurium-induced 100% Fade. Data indicate that the simultaneous blockage of M1 and M2 muscarinic receptors on motor nerve terminal by atropine is more efficient than the blockage of presynaptic A2A receptors for a safer recovery of patients from neuromuscular blockade caused by cisatracurium. 2016 artículo científico 1679-9291 https://www.redalyc.org/articulo.oa?id=307247622006 https://www.redalyc.org/journal/3072/307247622006/ https://www.redalyc.org/journal/3072/307247622006/html/ https://www.redalyc.org/journal/3072/307247622006/307247622006.epub https://www.redalyc.org/journal/3072/307247622006/movil en http://www.redalyc.org/revista.oa?id=3072 Acta Scientiarum. Health Sciences application/pdf Universidade Estadual de Maringá Acta Scientiarum. Health Sciences (Brasil) Num.2 Vol.38 |
| format | Artículo científico |
| id | redalyc_307247622006 |
| institution | Redalyc |
| language | en |
| publishDate | 2016 |
| publisher | Universidade Estadual de Maringá |
| spellingShingle | Atropine is more efficient than ZM241385 to reduce a drastic level of fade caused by cisatracurium at 50 Hz Arethusa Lobo Pimentel Medicina of four train adenosine Tetanic fade Atropine is more efficient than ZM241385 to reduce a drastic level of fade caused by cisatracurium at 50 Hz Arethusa Lobo Pimentel Gabriela de Castro Prado Wilson Alves-Do-Prado Célia Regina Ambiel Medicina of four train adenosine Tetanic fade The effects of atropine (non selective muscarinic antagonist) and ZM241385 (A2A receptors antagonist) in the cisatracurium-induced drastic (100%) level of fade at 50 Hz (10 s) (100% Fade) were compared in the phrenic nerve-diaphragm muscle preparations of rats indirectly stimulated at a physiological tetanic frequency (50 Hz). The lowest dose and the instant cisatracurium caused 100% Fade were investigated. Cisatracurium induced 100% Fade 15 min after being administered. Atropine reduced the cisatracurium-induced 100% Fade, but the administration of ZM241385 separately, or combined with atropine, did not cause any effect in the cisatracurium-induced 100% Fade. Data indicate that the simultaneous blockage of M1 and M2 muscarinic receptors on motor nerve terminal by atropine is more efficient than the blockage of presynaptic A2A receptors for a safer recovery of patients from neuromuscular blockade caused by cisatracurium. 2016 artículo científico 1679-9291 https://www.redalyc.org/articulo.oa?id=307247622006 https://www.redalyc.org/journal/3072/307247622006/ https://www.redalyc.org/journal/3072/307247622006/html/ https://www.redalyc.org/journal/3072/307247622006/307247622006.epub https://www.redalyc.org/journal/3072/307247622006/movil en http://www.redalyc.org/revista.oa?id=3072 Acta Scientiarum. Health Sciences application/pdf Universidade Estadual de Maringá Acta Scientiarum. Health Sciences (Brasil) Num.2 Vol.38 |
| title | Atropine is more efficient than ZM241385 to reduce a drastic level of fade caused by cisatracurium at 50 Hz |
| topic | Medicina of four train adenosine Tetanic fade |
| url | https://www.redalyc.org/articulo.oa?id=307247622006 https://www.redalyc.org/journal/3072/307247622006/ https://www.redalyc.org/journal/3072/307247622006/html/ https://www.redalyc.org/journal/3072/307247622006/307247622006.epub https://www.redalyc.org/journal/3072/307247622006/movil |