Chlorpyrifos induces genotoxic effects in human leukocytes in vitro at low concentrations
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| Format: | Artículo científico |
| Langue: | en |
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Universidade Estadual de Maringá
2019
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| _version_ | 1876422814312955904 |
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| author | Elvio Adílio Serpa |
| author_facet | Elvio Adílio Serpa |
| contents | Chlorpyrifos induces genotoxic effects in human leukocytes in vitro at low concentrations Elvio Adílio Serpa Elisandra Gomes Schmitt Luísa Zuravski Michel Mansur Machado Luís Flávio Souza de Oliveira Medicina Pesticide genotoxicity chlorpyrifos clastogenic effect Chlorpyrifos (CPF) is an organophosphate widely marketed as a pesticide. However, only few studies have investigated its genotoxic potential, especially in human tissues or cells, or the minimal concentration capable of inducing damage. This study analyzed the in vitro genotoxic potential of CPF in cultured human leukocytes at concentrations of 3, 35, and 350 μg mL-1. Results demonstrated that the two highest concentrations exhibited an increase (~2-fold) in the micronucleus frequency (p < 0.01), the number of numerical chromosomal instabilities (~10–12 times, p < 0.05), and the number of apoptotic cells (~10- to 20-fold, p < 0.001). These results demonstrate the genotoxic potential of CPF and could open new discussions regarding its safety and toxicology. 2019 artículo científico 1679-9291 https://www.redalyc.org/articulo.oa?id=307261031021 https://www.redalyc.org/journal/3072/307261031021/ https://www.redalyc.org/journal/3072/307261031021/html/ https://www.redalyc.org/journal/3072/307261031021/307261031021.epub https://www.redalyc.org/journal/3072/307261031021/movil https://doi.org/10.4025/actascihealthsci.v41i1.44291 en http://www.redalyc.org/revista.oa?id=3072 Acta Scientiarum. Health Sciences application/pdf Universidade Estadual de Maringá Acta Scientiarum. Health Sciences (Brasil) Vol.41 |
| format | Artículo científico |
| id | redalyc_307261031021 |
| institution | Redalyc |
| language | en |
| publishDate | 2019 |
| publisher | Universidade Estadual de Maringá |
| spellingShingle | Chlorpyrifos induces genotoxic effects in human leukocytes in vitro at low concentrations Elvio Adílio Serpa Medicina Pesticide genotoxicity chlorpyrifos clastogenic effect Chlorpyrifos induces genotoxic effects in human leukocytes in vitro at low concentrations Elvio Adílio Serpa Elisandra Gomes Schmitt Luísa Zuravski Michel Mansur Machado Luís Flávio Souza de Oliveira Medicina Pesticide genotoxicity chlorpyrifos clastogenic effect Chlorpyrifos (CPF) is an organophosphate widely marketed as a pesticide. However, only few studies have investigated its genotoxic potential, especially in human tissues or cells, or the minimal concentration capable of inducing damage. This study analyzed the in vitro genotoxic potential of CPF in cultured human leukocytes at concentrations of 3, 35, and 350 μg mL-1. Results demonstrated that the two highest concentrations exhibited an increase (~2-fold) in the micronucleus frequency (p < 0.01), the number of numerical chromosomal instabilities (~10–12 times, p < 0.05), and the number of apoptotic cells (~10- to 20-fold, p < 0.001). These results demonstrate the genotoxic potential of CPF and could open new discussions regarding its safety and toxicology. 2019 artículo científico 1679-9291 https://www.redalyc.org/articulo.oa?id=307261031021 https://www.redalyc.org/journal/3072/307261031021/ https://www.redalyc.org/journal/3072/307261031021/html/ https://www.redalyc.org/journal/3072/307261031021/307261031021.epub https://www.redalyc.org/journal/3072/307261031021/movil https://doi.org/10.4025/actascihealthsci.v41i1.44291 en http://www.redalyc.org/revista.oa?id=3072 Acta Scientiarum. Health Sciences application/pdf Universidade Estadual de Maringá Acta Scientiarum. Health Sciences (Brasil) Vol.41 |
| title | Chlorpyrifos induces genotoxic effects in human leukocytes in vitro at low concentrations |
| topic | Medicina Pesticide genotoxicity chlorpyrifos clastogenic effect |
| url | https://www.redalyc.org/articulo.oa?id=307261031021 https://www.redalyc.org/journal/3072/307261031021/ https://www.redalyc.org/journal/3072/307261031021/html/ https://www.redalyc.org/journal/3072/307261031021/307261031021.epub https://www.redalyc.org/journal/3072/307261031021/movil https://doi.org/10.4025/actascihealthsci.v41i1.44291 |